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51.发明授权BRANCHED POLYOXAALKYL MACROMOLECULES, PROCESS FOR MAKING THEM AND THEIR USES 失效支链聚氧大分子，其制造方法相同，它们的用途
公开(公告)号：EP0750649B1
公开(公告)日：2001-12-19
申请号：EP95913106.1
申请日：1995-03-14
CPC分类号： B82Y5/00 , A61K47/59 , A61K47/60 , A61K47/6949 , A61K51/065 , C08G65/329 , C08G65/34 , C08G83/003
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52.发明公开
公开(公告)号：EP1133346A1
公开(公告)日：2001-09-19
申请号：EP99972943.7
申请日：1999-11-24
CPC分类号： B01D61/04 , B01D61/027 , B01D2311/04 , C01B7/14 , B01D2311/12 , B01D2311/18 , B01D2311/10
摘要： A process for the recovery of iodine from mother liquors or wastes containing iodinated organic compounds, by mineralisation of organic iodine and subsequent transformation of the formed iodide into elementary iodine, characterized in that the aqueous solution is concentrated to a suitable volume before the mineralisation step, under atmospheric pressure and at the boiling temperature, and said solution is purified by nanofiltration.
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公开(公告)号：EP0850262B1
公开(公告)日：2001-05-23
申请号：EP96931048.1
申请日：1996-09-09
发明人： GOZZINI, Luigia , MUTTONI, Monica
CPC分类号： C08G83/003 , C08G65/329 , C08G65/34 , Y10S424/16
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54.发明公开A PROCESS FOR THE PREPARATION OF 4-CARBOXY- 5,8,11- TRIS(CARBOXYMETHYL)- 1-PHENYL- 2-OXA- 5,8,11- TRIAZATRIDECAN- 13-OIC ACID 有权为4-羧基-5,8,11-三（羧甲基）生产方法-1-苯基-2-氧杂-5,8,11- triazatridecan -13-羧酸
公开(公告)号：EP1095009A2
公开(公告)日：2001-05-02
申请号：EP99931207.7
申请日：1999-06-29
发明人： AUSONIO, Marina , DISTASO, Carlo , ELIA, Giuseppe, Gerardo , LESIGNOLI, Alessandro , PIVA, Rodolfo , SECCHI, Carlo , VISCARDI, Carlo, Felice
IPC分类号： C07C227/08 , C07C229/36 , C07C51/41 , C07C59/58
CPC分类号： C07C51/412 , C07C51/02 , C07C51/09 , C07C227/08 , C07C229/36 , C07C59/66 , C07C59/58
摘要： A novel process for the preparation of the chelating agent of formula (I), 4-carboxy- 5,8,11- tris(carboxymethyl)- 1-phenyl-2-oxa-5,8,11-triazatridecan-13-oic acid, commonly named BOPTA.
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公开(公告)号：EP3442949A1
公开(公告)日：2019-02-20
申请号：EP17714818.6
申请日：2017-04-05
发明人： LATTUADA, Luciano , NAPOLITANO, Roberta , BOI, Valeria , VISIGALLI, Massimo , AIME, Silvio , GIOVENZANA, Giovanni, Battista , FRINGUELLO MINGO, Alberto
IPC分类号： C07D257/02 , A61B5/055 , A61K49/06 , C07F9/6524
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公开(公告)号：EP2555803B1
公开(公告)日：2018-09-12
申请号：EP11712872.8
申请日：2011-04-08
发明人： AIME, Silvio , GIOVENZANA, Giovanni, Battista , TEDOLDI, Fabio , MAIOCCHI, Alessandro , UGGERI, Fulvio , JENSEN, Pernille, Rose , KARLSSON, Magnus , LERCHE, Mathilde, H. , VISIGALLI, Massimo , CROSETTI, Marco , POGGI, Luisa
IPC分类号： A61K49/10
摘要： The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.
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公开(公告)号：EP2931696B1
公开(公告)日：2018-08-22
申请号：EP13801552.4
申请日：2013-12-04
发明人： CERAGIOLI, Silvia , DELOGU, Pietro , MORTILLARO, Armando , NARDELLI, Alfonso , SGUASSERO, Stefano , VELARDI, Rosario , VISCARDI, Carlo Felice
IPC分类号： C07C67/287 , C07C67/313 , C07C67/08 , C07C71/00
CPC分类号： C07C67/313 , C07C67/08 , C07C67/287 , C07C71/00 , Y02P20/582 , C07C69/14
摘要： The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol.
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公开(公告)号：EP1965325B1
公开(公告)日：2018-05-09
申请号：EP07425110.9
申请日：2007-03-01
发明人： Canepa, Valtero
IPC分类号： G06F19/00
CPC分类号： G07F17/0092 , A61J3/002 , G06F19/00 , G06F19/321 , G06F19/3462 , G16H10/65
摘要： Therapeutic/diagnostic device comprising: at least a means (1) containing at least a drug or the like; a drug identification device (2), of RFID type, comprising a memory (102), means for reading and writing said memory and transmitting and receiving means (202) and which identification device (2) being univocally associated to a means (1) containing at least a drug; information about said drug being stored in said memory (102); at least an operating unit (3) for using said drug and said said operating unit comprising receiving and transmitting means (103) intended for communicating with receiving and transmitting means (202) of the drug identification device (2) for retrieving information within the memory (102) of said drug identification device (2). According to the invention the memory (102) of the identification device (2) has at least a protocol for administrating and dispensing the drug that is automatically retrieved by an operating unit (3) using the drug, which operating unit comprises one or more tools (303) intended to carry out predetermined tasks on, with or in the presence of said drug and means (403) controlling said tools using the administration and dispensing protocol as a driver controlling at least some of said tools (303).
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公开(公告)号：EP3174558A1
公开(公告)日：2017-06-07
申请号：EP15738943.8
申请日：2015-07-22
发明人： ELISEI, Elena , CESARO, Attilio , FILIBIAN, Marta , CARRETTA, Pietro , COLOMBO SERRA, Sonia , MAIOCCHI, Alessandro , TEDOLDI, Fabio
IPC分类号： A61K49/10
摘要： A method for preparing a sample for dynamic nuclear polarization which comprises submitting a solid substrate to a milling process in the presence of a polarizing agent at a temperature lower than the glass-transition temperature (Tg) of said substrate. Preferably said substrate may be in crystalline form.
摘要翻译： 制备用于动态核极化的样品的方法，该方法包括在低于所述底物的玻璃化转变温度（Tg）的温度下，在极化剂存在下将固体基质提供给研磨过程。 优选地，所述基材可以是结晶形式。
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