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公开(公告)号：EP1861483A1
公开(公告)日：2007-12-05
申请号：EP06736268.1
申请日：2006-02-28
CPC分类号： C10L1/026 , C07C67/03 , C07D317/20 , C11C3/00 , C11C3/003 , Y02E50/13 , Y02P20/127 , Y02P20/582 , C07C69/52 , C07C69/24
摘要： A process for the preparation of a fuel oil (diesel fuel or heating oil) composition which is a mixture of an alkanol tranesterified fatty acid ester triglyceride and an acetal of glycerol is described. The process preferably provides a prestep of the formation of at least some of the alkanol transesterif ied triglyceride containing the glycerol for use in the formation of the acetal of glycerol . The composition can also be formed from a reaction of 1,1- dimethoxy- or 1, l-diethoxye thane and glycerol to form the acetal in the alkanol transesterif ied triglyceride.
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公开(公告)号：EP0516811B2
公开(公告)日：2007-10-24
申请号：EP92902903.1
申请日：1991-12-19
CPC分类号： A61K31/00 , A61K31/47 , A61K31/16 , A61K2300/00
摘要： An euthanasia solution based upon gamma-hydroxybutramide and a cardiotoxic amount of a compound selected from chloroquine and quinacrine is described. The composition provides effective euthanasia without unwanted side effects.
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公开(公告)号：EP1784379A1
公开(公告)日：2007-05-16
申请号：EP05760216.1
申请日：2005-06-21
CPC分类号： B01D3/009 , C07C67/03 , C07C67/08 , Y02P20/127 , C07C69/68
摘要： A process for producing organic acid esters using continuous countercurrent reactive distillation using acid catalysts in a structured packing in a single column (10) is described. In the reactive distillation an organic acid ester is formed by chemical reaction and can be purified to its final state within the single column. Organic acid esters are produced at relatively low cost, with less waste production, and in a less complicated manner than prior processes. Organic acid ester havé uses as solvents, as intermediate chemicals, and in consumer products.
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54.发明公开
公开(公告)号：EP1657244A1
公开(公告)日：2006-05-17
申请号：EP05024562.0
申请日：2005-11-10
发明人： Hollingsworth, Rawle I. , Gao, Li
IPC分类号： C07D513/04 , A61K31/54 , A61P3/00
CPC分类号： C07D513/04
摘要： A process for producing 2-thiaquiolizidines which are glycosidase and glycosyltransferase inhibitors is described. The compounds are of the formula:
where x is 0 to 3.摘要翻译： 描述了制备作为糖苷酶和糖基转移酶抑制剂的2-硫杂吖啶的方法。 化合物具有下式：其中x为0至3。
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公开(公告)号：EP1644408A1
公开(公告)日：2006-04-12
申请号：EP04778551.4
申请日：2004-07-15
发明人： AYLSWORTH, Charles , JUDGE, John, W. , ROSENBURG, Barnett , HO, Siu-Cheong , JUCKETT, David , ZLATKIN, Igor, V. , ZLATKIN, Tatiana
IPC分类号： C07K14/455 , A61K39/012
CPC分类号： A61K39/39 , A61K38/16 , A61K39/012 , A61K2039/55516 , C07K14/455
摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.
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公开(公告)号：EP1643827A2
公开(公告)日：2006-04-12
申请号：EP04778341.0
申请日：2004-07-15
发明人： BENNING, Christoph , RIEKHOF, Wayne
IPC分类号： A01H1/00
CPC分类号： C12N9/10 , C12N15/52 , C12N15/8247 , C12P7/6463 , C12P13/00
摘要： The present invention relates to compositions and methods for the production of Betaine lipids. The methods of the present invention comprise the expression of recombinant enzymes (e.g. from Rhodobacter sphaeroides) in host cells (e.g. bacteria, yeast, and plants) to produce Betaine lipid compounds including, but not limited to, Diacylglyceryl-O-4'-(N,N,N,-trimethyl) homoserine (DGTS). The methods and compositions of the present invention may be utilized such that the amount of phosphate containing fertilizer required for the growth of a particular plant is decreased.
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57.发明公开AMYLOID PLAQUE AS A TARGET FOR THERAPEUTICS THAT FUNCTION BY BLOCKING OR DISRUPTING CHITIN SYNTHESIS OR ACTIVITY 审中-公开淀粉样斑块为目的与功能，用于阻止或中断甲壳素或活性的药物
公开(公告)号：EP1603451A3
公开(公告)日：2005-12-21
申请号：EP04718561.6
申请日：2004-03-08
IPC分类号： A61B1/00
CPC分类号： G01N33/6896 , A61K49/006 , C12Q1/48 , G01N2333/91102 , G01N2500/00 , G01N2800/2821
摘要： Chitin has been discovered to accumulate in the diseased tissue of mammals, including humans, afflicted with a disease characterized by formation of congo red-staining plaques. Such diseases include Alzheimer's disease, spongiform encepalopathies, type II diabetes, atrial amyloidosis, and the like. A method for detecting the chitin in the mammal is described which is useful for diagnosing disease caused by accumulation of the chitin or amyloid plaques comprising chitin in tissue. Further described is a method for treating a disease in the mammal caused by the accumulation of chitin or amyloid plaques comprising chitin by administering a composition which inhibits formation of the chitin or degrades the chitin.
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58.发明公开AMYLOID PLAQUE AS A TARGET FOR THERAPEUTICS THAT FUNCTION BY BLOCKING OR DISRUPTING CHITIN SYNTHESIS OR ACTIVITY 审中-公开AMYLOID PLAQUE作为阻断或破坏甲状腺素合成或活性的治疗药物的目标
公开(公告)号：EP1603451A2
公开(公告)日：2005-12-14
申请号：EP04718561.6
申请日：2004-03-08
IPC分类号： A61B1/00
CPC分类号： G01N33/6896 , A61K49/006 , C12Q1/48 , G01N2333/91102 , G01N2500/00 , G01N2800/2821
摘要： Chitin has been discovered to accumulate in the diseased tissue of mammals, including humans, afflicted with a disease characterized by formation of congo red-staining plaques. Such diseases include Alzheimer's disease, spongiform encepalopathies, type II diabetes, atrial amyloidosis, and the like. A method for detecting the chitin in the mammal is described which is useful for diagnosing disease caused by accumulation of the chitin or amyloid plaques comprising chitin in tissue. Further described is a method for treating a disease in the mammal caused by the accumulation of chitin or amyloid plaques comprising chitin by administering a composition which inhibits formation of the chitin or degrades the chitin.
摘要翻译： 几丁质已被发现积聚在包括人在内的哺乳动物的患病组织中，患有以刚果红染色斑块形成为特征的疾病。 这些疾病包括阿尔茨海默病，海绵状脑病，II型糖尿病，心房淀粉样变性等。 描述了用于检测哺乳动物几丁质的方法，该方法可用于诊断由组织中几丁质或包含几丁质的淀粉样蛋白斑积聚引起的疾病。 进一步描述了通过施用抑制甲壳质形成或降解几丁质的组合物来治疗由甲壳素或包含几丁质的淀粉样蛋白斑积聚引起的哺乳动物疾病的方法。
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59.发明公开
公开(公告)号：EP1578723A3
公开(公告)日：2005-12-07
申请号：EP02807534.9
申请日：2002-10-17
发明人： HOLLINGSWORTH, Rawle, I. , WANG, Guijun , PADMAKUMAR, Raghavakaimal , MAO, Jianmin , ZHANG, Huiping , DAI, Zongmin , PUTHUPARAMPIL, Kanakamma
IPC分类号： C07D201/00
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60.发明公开
公开(公告)号：EP1578723A2
公开(公告)日：2005-09-28
申请号：EP02807534.9
申请日：2002-10-17
发明人： HOLLINGSWORTH, Rawle, I. , WANG, Guijun , PADMAKUMAR, Raghavakaimal , MAO, Jianmin , ZHANG, Huiping , DAI, Zongmin , PUTHUPARAMPIL, Kanakamma
IPC分类号： C07D201/00
CPC分类号： C40B40/04 , C07D263/20 , C07D263/24 , C07D413/12 , C07D417/12 , C12Q1/18 , C40B30/04 , C40B50/08 , G01N2333/31
摘要： A process for preparing N-(substituted)-C- (substituted methyl)-oxazolidinones, C-(substituted methyl)-oxazolidinones, and N-(substituted)-C- (substituted ethyl)-oxazolidinones, preferably chiral, from optically active C-(protected oxymethyl) oxazolidinones is described. The process can be used to produce combinatorial libraries of the above substituted oxazolidinones in a two or three step reaction comprising a plurality of reagents differing in numbers of carbons or particular substituted oxazolidinones. A number of substituted oxazolidinones produced using the above process have been discovered to have antimicrobial activity.
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