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公开(公告)号：EP1501921B2
公开(公告)日：2012-07-25
申请号：EP03724692.3
申请日：2003-04-28
发明人： COFFEY, Matthew, C.
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , C07K14/005 , C12N2720/12051 , C12N2720/12222 , C12N2720/12234 , C12N2720/12251
摘要： The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and compositions comprising the viruses prepared according to the present invention are also provided.
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公开(公告)号：EP1481084B1
公开(公告)日：2011-08-10
申请号：EP03704136.5
申请日：2003-02-26
发明人： COFFEY, Matthew, C.
CPC分类号： C12Q1/04 , C12N15/1131 , C12N2310/121 , C12Q1/701 , C12Q2521/337 , G01N33/569 , G01N33/56983 , G01N2333/14
摘要： The present invention provides a method of detecting adventitious agents in a composition comprising a microorganism by using ribozyme-expressing indicator cells, as well as indicator cells useful in such detection.
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53.发明公开MODULATING INTERSTITIAL PRESSURE AND ONCOLYTIC VIRAL DELIVERY AND DISTRIBUTION 审中-公开调制间质压力和溶瘤病毒释放和分配
公开(公告)号：EP2296678A1
公开(公告)日：2011-03-23
申请号：EP09753371.5
申请日：2009-05-27
IPC分类号： A61K35/76 , A61K31/337 , A61K31/436 , A61K31/555 , A61K31/675 , A61K38/20 , A61P35/00 , A61K41/00
CPC分类号： A61K31/555 , A61K31/337 , A61K31/436 , A61K31/675 , A61K35/765 , A61K38/2013 , C12N2720/12032 , A61K2300/00
摘要： Provided herein are methods of treating a proliferative disorder in a subject comprising decreasing interstitial pressure and/or increasing vascular permeability in the subject and administering to the subject an oncolytic virus. Such methods improve oncolytic viral delivery and distribution.
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公开(公告)号：EP2150613A4
公开(公告)日：2011-01-19
申请号：EP08748334
申请日：2008-05-21
CPC分类号： C12N7/00 , A61K35/13 , A61K2035/11 , C07K14/005 , C12N2720/12021 , C12N2720/12022
摘要： Provided herein is a mutant reovirus (e.g., a genetically-engineered ISVP). Compositions including mutant reoviruses and methods of using such mutant reoviruses are also provided.
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55.发明公开Clearance of RAS-mediated neoplastic cells from mixed cellular compositions using reovirus 审中-公开借助于呼肠孤病毒去除的ras介导的从混合细胞组合物的肿瘤细胞
公开(公告)号：EP2239321A1
公开(公告)日：2010-10-13
申请号：EP10007121.6
申请日：2001-05-02
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplasitc cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autografts back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
摘要翻译： 呼肠孤病毒可用于选择性地从细胞组合物移除的ras介导的neoplasitc细胞。 特别令人感兴趣的清除可能含有肿瘤细胞与呼肠孤病毒移栽自体移植物回受体，从而减少引入或重新引入肿瘤细胞进入收件人的风险前签名。
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56.发明授权COMBINATION THERAPY USING REOVIRUS AND ANTI-ANTIREOVIRUS ANTIBODIES FOR THE TREATMENT OF RAS-MEDIATED PROLIFERATIVE DISORDERS 有权联合治疗使用呼肠孤病毒和抗ANTIREOVIRUS抗体介导的RAS，增生性疾病的治疗
公开(公告)号：EP1309334B1
公开(公告)日：2009-02-11
申请号：EP01953727.3
申请日：2001-07-20
CPC分类号： A61K35/765 , A61K38/13 , C07K16/081 , C07K16/10 , C07K16/4216 , C12N9/1205 , C12N2720/12232 , Y10S435/948 , Y10S435/975 , A61K2300/00
摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The mammal may be selected from dogs, cats, sheep, goats, cattle, horses, pigs, mice, humans and non-human primates. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. In particular, the methods provide for reovirus treatment of immunosuppressed or immuno-deficient mammals to treat the proliferative disorders. Immunosuppression,immunoinhibition or otherwise inducing an immunodeficient state in a mammal renders the reovirus more effective. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells. Immune systems may be compromised by one or more of the following: an HIV infection; as a side effect of chemotherapy or radiation therapy; by selective removal of B and/or T cell populations; by removal of antibodies (anti-antireovirus antibodies or all antibodies), and the like.
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57.发明公开Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 审中-公开预防呼肠孤病毒识别以治疗细胞增殖性疾病的方法
公开(公告)号：EP2016948A2
公开(公告)日：2009-01-21
申请号：EP08006362.1
申请日：2001-07-20
发明人： Coffey, Matthew , Thompson, Bradley
CPC分类号： A61K35/765 , A61K38/13 , C07K16/081 , C07K16/10 , C07K16/4216 , C12N9/1205 , C12N2720/12232 , Y10S435/948 , Y10S435/975 , A61K2300/00
摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The mammal may be selected from dogs, cats, sheep, goats, cattle, horses, pigs, mice, humans and non-human primates. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. In particular, the methods provide for reovirus treatment of immunosuppressed or immuno-deficient mammals to treat the proliferative disorders. Immunosuppression, immunoinhibition or otherwise inducing an immunodeficient state in a mammal renders the reovirus more effective. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells. Immune systems may be compromised by one or more of the following: an HIV infection; as a side effect of chemotherapy or radiation therapy; by selective removal of B and/or T cell populations; by removal of antibodies (anti-antireovirus antibodies or all antibodies), and the like.
摘要翻译： 本发明涉及在哺乳动物中治疗细胞增殖性病症，特别是ras介导的细胞增殖性病症中预防呼肠孤病毒识别的方法。 哺乳动物可以选自狗，猫，绵羊，山羊，牛，马，猪，小鼠，人类和非人灵长类动物。 该方法包括抑制或以其他方式抑制哺乳动物的免疫系统，同时或随后在导致增殖细胞基本裂解的条件下向增殖细胞施用有效量的一种或多种呼肠孤病毒。 具体而言，所述方法提供免疫抑制或免疫缺陷哺乳动物的呼肠孤病毒治疗以治疗增殖性疾病。 免疫抑制，免疫抑制或以其他方式诱导哺乳动物的免疫缺陷状态使得呼肠孤病毒更有效。 该方法可以包括选择性去除可能干扰病毒全身递送的免疫成分; 防止宿主免疫系统识别呼肠孤病毒; 并在用呼肠孤病毒治疗后从免疫抑制或免疫不全宿主中除去病毒。 或者，可以在导致增殖细胞大量裂解的条件下将呼肠弧病毒给予具有减少的免疫应答系统的哺乳动物。 免疫系统可能受到以下一种或多种危害：HIV感染; 作为化疗或放疗的副作用; 通过选择性去除B和/或T细胞群体; 通过除去抗体（抗抗病毒抗体或全部抗体）等。
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58.发明公开Viruses for the treatment of cellular proliferative disorders 审中-公开Virenfürdie Behandlung vonzellulären，proliferativen Erkrankungen
公开(公告)号：EP1955703A1
公开(公告)日：2008-08-13
申请号：EP08009283.6
申请日：2000-11-08
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferative cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected form modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.
摘要翻译： 公开了通过向具有活化的Ras途径的增殖细胞施用病毒来治疗细胞增殖性病症的方法。 施用病毒使得其最终直接接触具有活化的Ras途径的增殖细胞。 增生性疾病包括但不限于赘生物。 病毒选自修饰的腺病毒，修饰的HSV，修饰的痘苗病毒和修饰的副痘病毒或病毒。 还公开了通过进一步施用免疫抑制剂来治疗细胞增殖性疾病的方法。
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公开(公告)号：EP1586634A1
公开(公告)日：2005-10-19
申请号：EP05009952.2
申请日：2001-07-20
CPC分类号： A61K35/765 , C12N7/00 , C12N2510/02 , C12N2720/12011 , C12N2720/12032 , C12N2720/12051
摘要： A simple and efficient method of producing mammalian reovirus is developed using HEK 293 cells. The method provides for fast production of reovirus in high yield. Furthermore, this method provides for a simpler purification procedure of the produced reovirus.
摘要翻译： 使用HEK 293细胞开发生产哺乳动物呼肠孤病毒的简单有效的方法。 该方法以高产率快速生产呼肠弧病毒。 此外，该方法提供了产生的呼肠孤病毒的更简单的纯化程序。
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公开(公告)号：EP1505992A1
公开(公告)日：2005-02-16
申请号：EP03722131.4
申请日：2003-05-07
CPC分类号： A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention provides a method for reducing pain associated with neoplasms in a mammal, comprising administering an effective amount of one or more oncolytic viruses. Preferably, the mammal also receives an analgesic, and the amount of analgesic required by the mammal is reduced when the oncolytic virus is administered. The oncolytic virus is preferably reovirus. The mammal may be additionally subject to other therapies, such as chemotherapy, immunotherapy, hormonal and/or radiation therapy.
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