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    TUMOR ANTIGEN PEPTIDE
    51.
    发明公开
    TUMOR ANTIGEN PEPTIDE 审中-公开
    肿瘤抗原肽

    公开(公告)号：EP3054010A1

    公开(公告)日：2016-08-10

    申请号：EP14850688.4

    申请日：2014-10-03

    申请人： Dainippon Sumitomo Pharma Co., Ltd. ,  Sapporo Medical University

    发明人： SATO, Noriyuki ,  TORIGOE, Toshihiko ,  HIROHASHI, Yoshihiko ,  KANASEKI, Takayuki ,  KOCHIN, Vitaly ,  TAKAYA, Akari ,  GOTO, Masashi

    IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  C07K16/28 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574

    摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting cancer stem cells; a tumor antigen peptide specifically exhibited by cancer stem cells; a pharmaceutical composition for the prevention and/or treatment of cancer, containing same as an effective component thereof; and a method for screening said tumor antigen peptide. A peptide indicated by YO-XO-ZO, a polyepitope peptide including at least one said peptide as an epitope peptide and having a plurality of epitope peptides joined therein, a polynucleotide that codes at least either the peptide or the polyepitope peptide, a pharmaceutical composition containing these as an effective component thereof, and a cancer prevention and/or treatment agent characterized by inducing CTLs.

    摘要翻译： 本发明的目的是提供：用于特异性检测癌症干细胞的检测剂; 癌症干细胞特异表现的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物，其含有作为其有效成分的药物组合物; 和筛选所述肿瘤抗原肽的方法。 由YO-XO-ZO表示的肽，包含至少一种所述肽作为表位肽并且具有连接在其中的多个表位肽的多表位肽，编码至少肽或多表位肽的多核苷酸，药物组合物 含有这些作为其有效成分的化合物，以及以诱导CTL为特征的癌症预防和/或治疗剂。

    STENT PLACEMENT DEVICE AND STENT PLACEMENT METHOD
    54.
    发明公开
    STENT PLACEMENT DEVICE AND STENT PLACEMENT METHOD 审中-公开
    支架放置装置和支架放置方法

    公开(公告)号：EP2198811A1

    公开(公告)日：2010-06-23

    申请号：EP08791285.3

    申请日：2008-07-17

    申请人： Sapporo Medical University ,  National University Corporation University of Fukui

    发明人： HYODOH, Hideki ,  SAKAI, Toyohiko

    IPC分类号： A61F2/82

    CPC分类号： A61F2/966 ,  A61F2/95 ,  A61F2002/9505 ,  A61F2002/9511

    摘要： A stent placement device and a stent placement method, despite a simple structure thereof, can surely and readily deploy a stent by placing a distal end thereof prior to a proximal end thereof, having favorably low invasiveness, and smoothly insert and arrange the stent into a desired position, without damaging an internal lumen inner wall. A placement device 1 for deploying a stent 2 in an internal lumen includes a guide wire 3 which guides said stent 2 into a desired position in the internal lumen, a proximal tip 4 which is fixed at an intermediate position of said guide wire 3 and provided with a stent anchoring portion for anchoring said stent 2, and a stent converging and retaining member 5 which converges and retains a stent proximal end opening portion 2a of said stent 2.

    摘要翻译： 尽管结构简单，支架放置装置和支架放置方法可以确定并容易地展开支架，即通过将支架放置装置和支架放置方法的远端放置在其近端之前，具有良好低的侵入性，并顺利地将支架插入和布置成 期望的位置，而不损坏内部管腔内壁。 用于将支架2展开在内腔中的放置装置1包括将所述支架2引导到内腔中的期望位置的引导线3，固定在所述引导线3的中间位置处并提供 具有用于锚定所述支架2的支架锚定部分以及会聚并保持所述支架2的支架基端开口部分2a的支架会聚保持部件5。

    FINGER ARTERY ELASTICITY MEASURING PROGRAM, FINGER ARTERY ELASTICITY MEASURING DEVICE, AND FINGER ARTERY ELASTICITY MEASURING METHOD
    58.
    发明公开
    FINGER ARTERY ELASTICITY MEASURING PROGRAM, FINGER ARTERY ELASTICITY MEASURING DEVICE, AND FINGER ARTERY ELASTICITY MEASURING METHOD 有权
    计划用于测量手指动脉，装置的弹力用于测量手指动脉和方法的应变能力，为测量手指动脉的应变能力

    公开(公告)号：EP2116182A1

    公开(公告)日：2009-11-11

    申请号：EP08711096.1

    申请日：2008-02-12

    申请人： Sapporo Medical University

    发明人： TANAKA, Gohichi ,  SAWADA, Yukihiro

    IPC分类号： A61B5/02 ,  A61B5/0245

    CPC分类号： A61B5/022 ,  A61B5/02007 ,  A61B5/02116 ,  A61B5/1455

    摘要： PROBLEMS TO BE SOLVED: A finger arterial elasticity measuring program, a finger arterial elasticity measuring device and a finger arterial elasticity measuring method are provided for making it possible to measure an elasticity index of a finger artery in accordance with a pulse wave of a finger artery without measuring a blood pressure in evaluating the elasticity of the finger artery related to the degree of arterial sclerosis in an easy and least expensive manner.
    MEANS FOR SOLVING THE PROBLEMS: A computer functioning by a finger arterial elasticity measuring program includes a pulse wave data memory unit 42, a cuff pressure data memory unit 43, a normalized pulse volume (NPV) calculating unit 52 for dividing an amplitude (ΔI) of an alternate component of a pulse wave by an average value of direct components (I) to calculate NPV, a relative cuff pressure (P r ) calculating unit 53 for calculating a difference between a cuff pressure at the maximum amplitude of the pulse wave and each cuff pressure as P r , an FEI calculating unit 54 for calculating a linear regression slope (n) of the following expression (1) as an elasticity index of a finger artery: ln(NPV)=ln(bn)-n·P r ...(1) where b is a constant.

    摘要翻译： 要解决的问题：一个手指动脉弹性测量程序，手指动脉弹性测量装置和手指动脉弹性测量方法提供了用于使得能够在用手指动脉的脉波在雅舞蹈手指动脉的弹性指数来衡量 而不在评价以容易和最便宜的方式有关动脉硬化的程度的手指动脉的弹性测定血压。 用于解决该问题：通过手指动脉弹性测量程序的计算机功能包括一脉波数据存储器单元42，袖带压数据存储单元43，归一化的脉冲体积（NPV）计算单元52，用于在振幅除以（“I ）的脉冲的替代部件的上（I）直接分量的平均值Wave通过计算NPV，相对袖带压（P r）的计算单元53，用于在脉冲波的最大振幅来计算袖带压力之间的差 并且每个袖带压力为P R，在FEI计算单元54用于计算下面的表达式（1）的线性回归的斜率（N），作为对手指的动脉弹性指数：LN（NPV）= LN（BN）N· P - [R ...（1）其中b是常数。

    DRUG CARRIER AND DRUG CARRIER KIT FOR INHIBITING FIBROSIS
    59.
    发明公开
    DRUG CARRIER AND DRUG CARRIER KIT FOR INHIBITING FIBROSIS 有权
    ARZNEIMITTELTRÄGERUNDARZNEIMITTELTRÄGERKITZUR HEMMUNG VON FIBROSE

    公开(公告)号：EP1842557A1

    公开(公告)日：2007-10-10

    申请号：EP05819552.0

    申请日：2005-12-22

    申请人： Sapporo Medical University

    发明人： NIITSU, Yoshiro, Sapporo Medical University ,  KATO, Junji, Sapporo Medical University ,  SATO, Yasushi, Sapporo Medical Unviesity

    IPC分类号： A61K47/10 ,  A61K9/107 ,  A61K9/127 ,  A61K9/50 ,  A61K9/51 ,  A61K31/7088 ,  A61K45/00 ,  A61K47/14 ,  A61K48/00 ,  A61P43/00

    CPC分类号： A61K31/07 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/14 ,  A61K31/7088 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/1858 ,  A61K45/06 ,  A61K47/6911 ,  Y10S514/893 ,  Y10T428/2982 ,  A61K2300/00

    摘要： An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.

    摘要翻译： 含有类视黄醇衍生物和/或维生素A类似物作为成分的星形细胞特异性药物载体; 使用该药物的药物递送方法; 含有该药物的药物 以及使用该药物的治疗方法。 通过将药物载体与维生素A或维生素A类似物的类视黄醇衍生物结合或将其封装在药物载体中，可以将治疗用途的药物特异性递送至星形胶质细胞。 结果，可以有效地，有效地抑制或预防星形胶质细胞相关疾病，同时尽量减少副作用。 作为抑制星形胶质细胞活性或生长的药物，例如可以将作为胶原特异性分子伴侣的HSP47的siRNA包封在药物载体中。 因此，可以同时抑制I型胶原蛋白的分泌，并且可以有效地抑制纤维化。

    IMAGE DIAGNOSIS APPARATUS, METHOD FOR OPERATING IMAGE DIAGNOSIS APPARATUS, AND PROGRAM
    60.
    发明公开
    IMAGE DIAGNOSIS APPARATUS, METHOD FOR OPERATING IMAGE DIAGNOSIS APPARATUS, AND PROGRAM 审中-实审

    公开(公告)号：EP4413921A1

    公开(公告)日：2024-08-14

    申请号：EP22878613.3

    申请日：2022-10-07

    申请人： Sapporo Medical University

    发明人： AKIYAMA, Yukinori

    IPC分类号： A61B5/055 ,  G06T7/00

    CPC分类号： G06T7/00 ,  A61B5/055

    摘要： An image diagnosis apparatus (100) includes an acquirer (152) to acquire a tomographic image including a region to be diagnosed of a subject and a drawer (153) to draw, based on a tomographic image acquired by the acquirer (152), a labeled image including the region to be diagnosed, the labeled image being partitioned according to classes indicating a lesion area, a normal tissue area, and a background area. The normal tissue area may be partitioned into a cavity area, a soft tissue area, and a bone area. The lesion area is a tumor area inside the brain, the tomographic image is an image of a cross section obtained by slicing the brain of the subject in the transverse plane direction at a plurality of points, and the drawer (153) may draw a labeled image corresponding to each tomographic image acquired by the acquirer (152).