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公开(公告)号：EP3359544A1
公开(公告)日：2018-08-15
申请号：EP16774683.3
申请日：2016-09-30
发明人： LÜCKING, Ulrich , HOG, Daniel , GEISLER, Jens , SCHOLZ, Arne , PETERSEN, Kirstin , LIENAU, Philip , STEGMANN, Christian , ANDRES, Dorothee , SIEMEISTER, Gerhard , WERBECK, Nicolas
IPC分类号： C07D498/08 , C07D498/18 , C07D515/08 , A61K31/529 , A61P35/00
摘要： The present invention relates to novel modified macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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52.发明授权SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. 有权用作BUB1激酶抑制剂用于治疗过度增殖性疾病的取代苯并噻唑类化合物。
公开(公告)号：EP2763982B1
公开(公告)日：2018-01-10
申请号：EP12766997.6
申请日：2012-10-04
发明人： HITCHCOCK, Marion , MENGEL, Anne , PÜTTER, Vera , SIEMEISTER, Gerhard , WENGNER, Antje Margret , BRIEM, Hans , EIS, Knut , SCHULZE, Volker , FERNANDEZ-MONTALVAN, Amaury Ernesto , PRECHTL, Stefan , HOLTON, Simon , FANGHÄNEL, Jörg , LIENAU, Philip , PREUSSE, Cornelia , GNOTH, Mark Jean
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/506 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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53.发明公开1,3,4-THIADIAZOL-2-YL-BENZAMIDE DERIVATIVES AS INHIBITORSOF THE WNT SIGNALLING PATHWAY 审中-公开作为WNT信号通路抑制剂的1,3,4-噻二唑-2-基苯甲酰胺衍生物
公开(公告)号：EP3259268A1
公开(公告)日：2017-12-27
申请号：EP16704644.0
申请日：2016-02-16
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William J. , GIESE, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred , GEISLER, Jens
IPC分类号： C07D417/12 , C07D417/14 , A61K31/454 , A61K31/496 , A61P35/00 , A61P37/02
CPC分类号： C07D285/135 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3230285A1
公开(公告)日：2017-10-18
申请号：EP15804859.5
申请日：2015-12-07
发明人： SCHULZE, Volker , LERCHEN, Hans-Georg , LÜCKING, Ulrich , WENGNER, Antje Margret , SIEMEISTER, Gerhard , LIENAU, Philip , KRENZ, Ursula
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, and their use for the treatment and/or prophylaxis of diseases.
摘要翻译： 本发明涉及Mps-1激酶抑制剂的前药衍生物，以及它们用于治疗和/或预防疾病的用途。
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公开(公告)号：EP2951175B1
公开(公告)日：2017-10-04
申请号：EP14701580.4
申请日：2014-01-29
发明人： KLAR, Ulrich , WORTMANN, Lars , KETTSCHAU, Georg , PÜHLER, Florian , LIENAU, Philip , SÜLZLE, Detlev
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D471/04
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56.发明授权3-ACETYLAMINO-1-(PHENYL-HETEROARYL-AMINOCARBONYL OR PHENYL-HETEROARYL-CARBONYLAMINO)BENZENE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS 有权3-乙酰氨基-1-（苯基 - 芳基 - 氨基羰基）苯基 - 邻苯二甲酰亚胺基）苯甲醛衍生物ZUR BEHANDLUNG VON HYPERPROLIFERATIVEN ERKRANKUNGEN
公开(公告)号：EP2976327B1
公开(公告)日：2017-06-21
申请号：EP14712631.2
申请日：2014-03-17
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William J. , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D213/75 , C07D498/08 , C07D277/46 , C07D277/56 , C07D333/38 , C07D213/82 , C07D263/34 , C07D207/34 , C07D285/135 , C07D271/06 , C07D231/14 , C07D271/07 , C07D401/12 , C07D417/12 , C07D487/08 , C07D271/113 , A61K31/4418 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/433 , A61K31/4418 , A61K31/4439 , A61K31/496 , A61K31/4995 , A61K31/5386 , A61K31/551 , A61K31/553 , A61K45/06 , C07C205/45 , C07C205/59 , C07C229/64 , C07C233/15 , C07C233/54 , C07C255/56 , C07C317/44 , C07D207/34 , C07D213/73 , C07D213/75 , C07D213/76 , C07D213/82 , C07D231/14 , C07D263/34 , C07D271/06 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D285/135 , C07D295/15 , C07D295/155 , C07D333/38 , C07D401/12 , C07D417/12 , C07D487/08 , C07D498/08
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公开(公告)号：EP3129387A1
公开(公告)日：2017-02-15
申请号：EP15715715.7
申请日：2015-04-08
发明人： LÜCKING, Ulrich , WASNAIRE, Pierre , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , STEGMANN, Christian , BÖMER, Ulf , ZHENG, Kunzeng , GAO, Ping , CHEN, Gang , XI, Jiajun
IPC分类号： C07D498/14 , A61K31/529 , A61P35/00
CPC分类号： C07D498/14 , A61K31/4375 , A61K31/519 , C07C53/18 , C07D498/04
摘要： The present invention relates to novel macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及本文所述和定义的通式（I）的新型大环化合物及其制备方法，其用于治疗和/或预防病症，特别是高增殖性疾病和/或病毒诱导的病症 传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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58.发明公开DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFONDIIMINE GROUP 审中-公开发现5氟荧光素衍生物麻醉剂亚硝酸盐
公开(公告)号：EP3126338A1
公开(公告)日：2017-02-08
申请号：EP15715198.6
申请日：2015-03-27
发明人： LÜCKING, Ulrich , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BOHLMANN, Rolf , BÖMER, Ulf
IPC分类号： C07D239/42 , A61K31/505 , A61P35/00
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07C309/30 , C07D401/12 , C07D405/04 , C07D407/04 , Y02A50/387
摘要： The present invention relates to 5-fluoro pyrimidine derivatives containing a sulfondiimine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及含有本文所述和定义的通式（I）的磺基亚胺基的5-氟嘧啶衍生物及其制备方法，其用于治疗和/或预防病症，特别是高增殖性 疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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59.发明公开AMIDO-SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE AND/OR ANGIOGENESIS DISORDERS 审中-公开AMIDOSUTISTITUIERTE咪达唑仑ZUR BEHANDLUNG VON HYPERPROLIFERATIVEN UND / ODER ANGIOGENESEERKRANKUNGEN
公开(公告)号：EP3092242A1
公开(公告)日：2016-11-16
申请号：EP15701101.6
申请日：2015-01-06
发明人： SCHULZE, Volker , EIS, Knut , PUEHLER, Florian , ZORN, Ludwig , SÜLZLE, Detlev , LIENAU, Philip , WENGNER, Antje Margret , PETERSEN, Kirstin , BÖMER, Ulf
IPC分类号： C07D487/04 , C07D491/04 , C07D519/00 , A61K31/5025 , A61P35/00 , A61P37/00
CPC分类号： C07D519/00 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D491/04
摘要： The present invention relates to amido-substituted imidazopyridazine compounds of general formula (I): in which A, E, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的酰胺取代的咪唑并哒嗪化合物：其中A，E，R2，R3，R4和n如权利要求中所定义，涉及制备所述化合物的方法，可用于制备 所述化合物，包含所述化合物的药物组合物和组合以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或 与其他活性成分组合。
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60.发明授权5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP 有权5-氟-N-（吡啶-2-基），其具有磺基肟吡啶-2-胺衍生物
公开(公告)号：EP2928878B1
公开(公告)日：2016-11-02
申请号：EP13792885.9
申请日：2013-11-12
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： A61K31/444 , C07D213/72 , C07D401/12
CPC分类号： A61K31/444 , C07D213/72 , C07D401/12
摘要： The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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