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公开(公告)号：EP2507233A1
公开(公告)日：2012-10-10
申请号：EP10782198.5
申请日：2010-11-17
发明人： SCHULZE, Volker , KOPPITZ, Marcus , KOSEMUND, Dirk , BADER, Benjamin , LIENAU, Philip , BRIEM, Hans , HOLTON, Simon , SIEMEISTER, Gerhard , PRECHTL, Stefan , WENGNER, Antje, Margret
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: Formula (I), in which R
1 , R
2 , R
3 , R
4 , and R
5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis proliferative of diseases, as well as to intermediate compounds useful in the preparation of said compounds.-
公开(公告)号：EP3359544B1
公开(公告)日：2020-08-12
申请号：EP16774683.3
申请日：2016-09-30
发明人： LÜCKING, Ulrich , HOG, Daniel , GEISLER, Jens , SCHOLZ, Arne , PETERSEN, Kirstin , LIENAU, Philip , STEGMANN, Christian , ANDRES, Dorothee , SIEMEISTER, Gerhard , WERBECK, Nicolas
IPC分类号： C07D498/08 , C07D498/18 , C07D515/08 , A61K31/529 , A61P35/00
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公开(公告)号：EP3402795B1
公开(公告)日：2019-10-30
申请号：EP17700500.6
申请日：2017-01-06
发明人： LÜCKING, Ulrich , KOPPITZ, Marcus , LEFRANC, Julien , WORTMANN, Lars , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BÖMER, Ulf , BADER, Benjamin , LIENAU, Philip , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
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公开(公告)号：EP3129387B1
公开(公告)日：2019-06-26
申请号：EP15715715.7
申请日：2015-04-08
发明人： LÜCKING, Ulrich , WASNAIRE, Pierre , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , STEGMANN, Christian , BÖMER, Ulf , ZHENG, Kunzeng , GAO, Ping , CHEN, Gang , XI, Jiajun
IPC分类号： C07D498/14 , A61K31/529 , A61P35/00
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公开(公告)号：EP3207037B1
公开(公告)日：2019-01-23
申请号：EP15777707.9
申请日：2015-10-13
IPC分类号： C07D405/04 , A61K31/506 , A61P35/00 , C07D239/42
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公开(公告)号：EP3390387A1
公开(公告)日：2018-10-24
申请号：EP16829402.3
申请日：2016-12-15
发明人： SCHULZE, Volker , HEINRICH, Tobias , PRINZ, Florian , LEFRANC, Julien , SCHRÖDER, Jens , MENGEL, Anne , BONE, Wilhelm , BÁLINT, Joszef , WENGNER, Antje Margret , EIS, Knut , IRLBACHER, Horst , KOPPITZ, Marcus , BÖMER, Ulf , BADER, Benjamin , BRIEM, Hans , LIENAU, Philip , CHRIST, Clara , STÖCKIGT, Detlef , HILLIG, Roman , EHEIM, Ashley , KOSEMUND, Dirk , MÖNNING, Ursula , HARB, Hassan, Y.
IPC分类号： C07D401/14 , C07D405/14 , C07D401/12 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08 , A61K31/407
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3207038B1
公开(公告)日：2018-08-22
申请号：EP15778981.9
申请日：2015-10-14
IPC分类号： C07D405/04 , A61K31/506 , A61P35/00
CPC分类号： C07D405/10 , A61K31/506 , C07D239/42 , C07D405/04
摘要： The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper- proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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公开(公告)号：EP3177619B1
公开(公告)日：2018-04-25
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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59.发明公开3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY 审中-公开作为WNT信号通路抑制剂的3-氨基甲酰基苯基-4-甲酰胺和异鼠李素衍生物
公开(公告)号：EP3259263A1
公开(公告)日：2017-12-27
申请号：EP16704456.9
申请日：2016-02-16
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William j. , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PÜHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D401/14 , C07D213/73 , C07D213/75 , C07D401/12 , A61K31/435 , A61P35/00 , C07C15/04
CPC分类号： A61K31/435 , C07C237/44 , C07D213/73 , C07D213/75 , C07D401/12 , C07D401/14
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients, in which: R1 represents a group selected from: C1-C3-alkoxy-C2-C5-alkyl-, (A), (B), (C), (D), (E), (F), (G) or (H); wherein * indicates the point of attachment to the rest of the molecule; R2 represents a group selected from: (I), (J) or (K); wherein * indicates the point of attachment to the rest of the molecule.
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公开(公告)号：EP3177619A1
公开(公告)日：2017-06-14
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的所述化合物的用途 疾病作为唯一的药剂或与其他活性成分组合。
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