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63 条记录 (耗时 0.016 秒)

    Sialic acid derivatives and process therefor
    52.
    发明公开
    Sialic acid derivatives and process therefor 失效
    唾液酸衍生物及其加工方法

    公开(公告)号：EP0479769A2

    公开(公告)日：1992-04-08

    申请号：EP92100069.1

    申请日：1987-07-03

    申请人： MECT CORPORATION

    发明人： Ogawa, Tomoya ,  Sugimoto, Mamoru ,  Numata, Masaaki ,  Yoshimura, Shoji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

    IPC分类号： C07H5/06 ,  C07H7/02 ,  A61K31/615 ,  A61K31/62 ,  C07H15/04 ,  C07H15/18

    CPC分类号： C07H15/10 ,  C07H3/06

    摘要： The present invention relates to sialic acid derivatives. According to the present invention, there is provided sialic acid derivatives having the general formula (I):

    wherein, R¹ represents hydrogen, an acetyl group, or a trityl group,
       R² represents hydrogen or an acetyl group,
       one of R³ and R⁴ represents chlorine, -OAc, -OH,

    , or

       (R⁷ represents a hydrogen atom or an acetyl group, R⁸ represents a hydrogen atom, an acetyl group or a benzyl group, R⁹ represents a hydrogen atom, an acetyl group, a benzyl group or

    or

    wherein R¹⁰ represents a hydrogen atom or a benzoyl group), while the other represents -COOR¹¹ wherein R¹¹ represents hydrogen, sodium, or a methyl group.

    摘要翻译： 本发明涉及唾液酸衍生物。 根据本发明，提供了具有通式（I）的唾液酸衍生物：其中R 1代表氢，乙酰基或三苯甲基，R 2代表氢或乙酰基，R 3和R 4之一代表氯 ，-OAc，-OH，或（R 8表示氢原子或乙酰基，R 7表示氢原子，乙酰基或苄基，R 7表示氢原子，乙酰基，苄基或 R 10代表氢原子或苯甲酰基），而另一个代表-COOR 11，其中R 11代表氢，钠或甲基。

    Sialic acid-bonded octapeptide and preparation thereof
    55.
    发明公开
    Sialic acid-bonded octapeptide and preparation thereof 失效
    An Sial-Säuregebundenes Oktapeptid und dessen Herstellung。

    公开(公告)号：EP0348892A2

    公开(公告)日：1990-01-03

    申请号：EP89111675.8

    申请日：1989-06-27

    申请人： MECT CORPORATION ,  MITSUI TOATSU CHEMICALS, Inc.

    发明人： Nagai, Yoshitaka ,  Shibayama, Shohei ,  Numata, Masaaki ,  Yoshimura, Shoji ,  Tanaka, Makoto ,  Ito, Masayoshi ,  Awaya, Akira ,  Kobayashi, Hisashi ,  Abe, Hayao ,  Ishizuka, Yusaku ,  Ogawa, Tomoya

    IPC分类号： C07K15/00 ,  C07K9/00 ,  C07K7/06

    CPC分类号： C07K9/005 ,  C07K9/001 ,  Y02P20/55

    摘要： A sialic acid-bonded octapeptide represented by the following general formula (I):
    wherein R represents a hydrogen atom or an acetyl group; and R′ represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein desclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.

    摘要翻译： 由以下通式（I）表示的唾液酸键合八肽：其中R表示氢原子或乙酰基; R min表示低级烷基，芳烷基，氢原子或碱金属原子。 唾液酸键合的八肽的肽链由FTS的C末端侧的8个氨基酸分子构成，通过将唾液酸键合到肽链的氨基末端，可以得到式（I）所示的化合物， 冷凝。 这些八肽显示与FTS相当的优异的生理活性和血液中的半衰期比FTS更长，并且预期肽对淋巴细胞的亲和力也增强。 因此，它们可以有效地用作治疗胸腺功能降低和异常的药物。

    Monoclonal antibody recognizing alpha 2-- 3 bonds
    56.
    发明公开
    Monoclonal antibody recognizing alpha 2-- 3 bonds 失效
    Alpha 2-3-Verbindungen erkennender monokeparerAntikörper。

    公开(公告)号：EP0316882A2

    公开(公告)日：1989-05-24

    申请号：EP88119045.8

    申请日：1988-11-15

    申请人： MECT CORPORATION

    发明人： Nagai, Yoshitaka ,  Yamamoto, Hideki ,  Takada, Kinji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

    IPC分类号： C12N5/12 ,  C12P21/08

    CPC分类号： G01N33/574 ,  G01N33/5743 ,  G01N33/57469 ,  G01N33/92 ,  Y10S424/807 ,  Y10S530/864

    摘要： A hybridoma capable of procuding a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-­acetylneuraminic acid residue having alpha 2--→ 3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with a sialic acid containing glycolipid carrying N-­acetylneuraminic acid residue having alpha 2--→ 3 linkage and (ii) myeloma cells. The monoclonal antibody produced by the hybridoma can be used for purifying gangliosides, for treating patients suffering from melanoma and for diagnosing sera.

    摘要翻译： 本文公开了能够诱导具有含唾液酸的糖脂的单克隆抗体的杂交瘤，其携带具有α2 - > 3键的N-乙酰神经氨酸残基。 杂交瘤可以通过融合（i）通过用携带具有α2→3连接的N-乙酰神经氨酸残基和（ii）骨髓瘤细胞的含唾液酸的糖脂免疫动物获得的B细胞或淋巴细胞产生。 由杂交瘤产生的单克隆抗体可用于纯化神经节苷脂，用于治疗患有黑素瘤的患者和用于诊断血清。

    Monoclonal antibodies capable of recognizing N-acetylneuraminic acid in beta-arrangement
    57.
    发明公开
    Monoclonal antibodies capable of recognizing N-acetylneuraminic acid in beta-arrangement 失效
    在Beta-Stellung N-AcetylneuraminsäureidentifizierungsfähigemonoklonaleAntikörper。

    公开(公告)号：EP0316818A2

    公开(公告)日：1989-05-24

    申请号：EP88118876.7

    申请日：1988-11-11

    申请人： MECT CORPORATION

    发明人： Kawamura, Atsushi ,  Suda, Isao ,  Takada, Kinji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

    IPC分类号： C12P21/08

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K16/30

    摘要： A hybridoma producing a monoclonal antibody specific to N-acetylneuraminic acid or a derivative thereof in the beta-arrangement as an epitope or antigenic determinant is herein disclosed. The monoclonal antibody produced by the hybridoma can be used in clinical purposes such as diagnosis and/or prognosis of a certain kinds of cancers and acute inflammatory diseases. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with an N-acetylneuraminic acid or a derivative thereof in beta-arrangement as an antigen and (ii) myeloma cells.

    摘要翻译： 本文公开了在β-排列中产生对N-乙酰神经氨酸或其衍生物特异性的单克隆抗体作为表位或抗原决定簇的杂交瘤。 由杂交瘤产生的单克隆抗体可用于临床目的，例如某些种类的癌症和急性炎性疾病的诊断和/或预后。 杂交瘤可以通过将（i）以β-排列的N-乙酰神经氨酸或其衍生物免疫动物获得的B细胞或淋巴细胞作为抗原和（ii）骨髓瘤细胞融合来产生。

    Sialic acid derivatives having active carbonyl group
    58.
    发明公开
    Sialic acid derivatives having active carbonyl group 失效
    Sialsäure-Derivate，die eine aktive Carbonylgruppe haben。

    公开(公告)号：EP0273388A2

    公开(公告)日：1988-07-06

    申请号：EP87119132.6

    申请日：1987-12-23

    申请人： MECT CORPORATION

    发明人： Yoshimura, Shoji ,  Shibayama, Shohei ,  Numata, Masaaki ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

    IPC分类号： C07H15/04 ,  C07H15/26 ,  A61K31/70 ,  B01J20/26

    CPC分类号： C07H15/04 ,  A61K47/26

    摘要： A sialic acid derivative having an active carbonyl group represented by the formula [I]:
    (wherein R' represents hydrogen or acetyl group; R 2 represents hydrogen, a metal or a lower alkyl group; R 3 represents hydrogen, hydroxyl group, or a residue removed hydrogen from an alcohol portion of an active ester; Ac represents acetyl group; and n is 1 to 20, respectively). This sialic acid derivative [I] can be utilized as a starting material for various complex having a sialic acid in the molecule since it has an active carbonyl group in the molecule so that it shows high reactivity.

    摘要翻译： 具有由式[I]表示的活性羰基的唾液酸衍生物：其中R 1表示氢或乙酰基; R 2表示氢，金属或低级烷基; R 3 >表示氢，羟基或从活性酯的醇部分除去氢的残基; Ac表示乙酰基，n分别为1〜20）。 该唾液酸衍生物[I]可用作分子中具有唾液酸的各种络合物的起始原料，因为其在分子中具有活性羰基，因此其显示高反应性。

    Sialic acid derivatives and process therefor
    59.
    发明公开
    Sialic acid derivatives and process therefor 失效
    酸性衍生物及其过程

    公开(公告)号：EP0254105A3

    公开(公告)日：1988-04-20

    申请号：EP87109631

    申请日：1987-07-03

    申请人： MECT CORPORATION

    发明人： Ogawa, Tomoya ,  Sugimott, Mamoru ,  Numata, Masaaki ,  Yoshimura, Shoji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

    IPC分类号： C07H15/10 ,  A61K31/70 ,  C07H03/06

    CPC分类号： C07H15/10 ,  C07H3/06

    摘要： The present invention relates to sialic acid derivatives. According to the present invention, there is provided sialic acid derivatives having the general formula (I):
    wherein, R 1 represents hydrogen, an acetyl group, a trityl group,
    (R 5 represents hydrogen or an acetyl group and R 6 represents hydrogen, sodium or a methyl group). R 2 represents hydrogen or an acetyl group, one of R 3 and R 4 represents chlorine, -OAc, -OH, -OCH 2 CH = CH 2 .
    , or
    (R 7 represents a hydrogen atom or an acetyl group, R 8 represents a hydrogen atom, an acetyl group or a benzyl group, R 9 represents a hydrogen atom, an acetyl group, a benzyl group or
    or
    wherein R 10 represents a hydrogen atom or a benzoyl group), while the other represents -COOR 11 wherein R" represents hydrogen, sodium, or a methyl group.