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公开(公告)号：EP2673088A1
公开(公告)日：2013-12-18
申请号：EP12706734.6
申请日：2012-02-06
发明人： ABATE, Adam, R. , WEITZ, David, A.
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L3/502784 , B01L2200/0673 , B01L2200/12 , B01L2300/0816 , B01L2300/0864 , B01L2300/123 , Y10T137/0318 , Y10T137/85938
摘要： The present invention generally relates to fluidics and microfluidics and, in particular, to creating droplets in a fluidic system. In some aspects, the present invention is generally directed to systems and methods for splitting a parent droplet into two or more droplets, e.g., by urging the parent droplet towards an obstacle to split the parent droplet. In some cases, the parent droplet is split into at least first and second droplets which each are directed to separate channels. In some cases, the channels may be constructed and arranged such that the droplet velocities of the first and second droplets are substantially the same as the velocity of the parent droplet. In some cases, such droplets may be repeatedly split, e.g., a parent droplet is divided into 2 daughter droplets, then each droplet split again, etc., for example, such that one parent droplet may eventually be split into 22, 23, 24, 25, 26, etc. daughter droplets. In some cases, the daughter droplets may be substantially monodisperse.
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公开(公告)号：EP2608772A2
公开(公告)日：2013-07-03
申请号：EP11749695.0
申请日：2011-08-23
IPC分类号： A61K9/14 , A61K9/16 , A61K31/565 , A61K31/58
CPC分类号： A61K9/143 , A61K9/1694 , A61K31/565 , A61K31/58
摘要： The present invention generally relates to particles for drug delivery and other applications. In one aspect, the present invention relates to a technique for reacting precursor compounds in the presence of a pharmaceutically- active agent to form product (e.g., in the form of particles) in which the agent is substantially contained within the product, and the product is soluble within typical gastric fluid of a mammal. In another aspect, the present invention is generally directed to particles comprising an inorganic pharmaceutically acceptable carrier, such as CaCO
3 , and an agent. In some cases, at least some of the agent contained within the particles is fluidically inaccessible from externally of the particle. For instance, the agent may be present in isolated domains within the particle. In another aspect, the present invention is generally directed to methods of creating particles. For instance, according to one set of embodiments, two fluids containing reactants are mixed where, upon reaction of the reactants, an insoluble product is formed, which precipitates to form particles. In one example, a first fluid containing dissolved carbonate ions and a second fluid containing dissolved calcium ions and a pharmaceutically- active agent are mixed together; upon mixing of the first and second fluids, the calcium ions and the carbonate ions form calcium carbonate, which precipitates to form a co-precipitate with the pharmaceutically- active agent. Yet other aspects of the present invention are directed to particles formed from such reactions, methods of using such reactions, methods of promoting such reactions, kits involving particles, or the like.-
公开(公告)号：EP2547436A2
公开(公告)日：2013-01-23
申请号：EP11716682.7
申请日：2011-03-17
CPC分类号： B01J13/0086 , B01F3/0807 , B01F13/0062 , B01F2005/0034 , B01J13/04 , C09B67/0009 , C09B67/0097 , G01N2015/1413
摘要： The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.
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公开(公告)号：EP2373812A1
公开(公告)日：2011-10-12
申请号：EP09804166.8
申请日：2009-12-18
发明人： WEITZ, David, A. , ABATE, Adam, R.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , B01L3/502761 , B01L2200/10 , C12Q1/6834 , C12Q1/6869 , C12Q1/6874 , C12Q2525/204 , C12Q2563/149 , C12Q2563/159 , C12Q2565/629
摘要： This invention generally relates to particle-assisted nucleic acid sequencing. In some embodiments, sequencing may be performed in a microfluidic device, which can offer desirable properties, for example, minimal use of reagents, facile scale-up, and/or high throughput. In one embodiment, a target nucleic acid may be exposed to particles having nucleic acid probes. By determining the binding of the particles to the target nucleic acid, the sequence of the target nucleic acid (or at least a portion of the target nucleic acid) can be determined. The target nucleic acid may be encapsulated within a fluidic droplet with the particles having nucleic acid probes, in certain instances. In some cases, the sequence of the target nucleic acid may be determined, based on binding of the particles, using sequencing by hybridization (SBH) algorithms or other known techniques.
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55.发明公开VALVES AND OTHER FLOW CONTROL IN FLUIDIC SYSTEMS INCLUDING MICROFLUIDIC SYSTEMS 有权阀门等流量调节器件FUIDSYSTEMEN INSBESONDER微流体系统
公开(公告)号：EP2286125A2
公开(公告)日：2011-02-23
申请号：EP09746985.2
申请日：2009-05-15
发明人： ABATE, Adam, R. , WEITZ, David, A.
CPC分类号： B01L3/502738 , B01L3/0268 , B01L3/502746 , B01L3/502784 , B01L2200/0605 , B01L2200/0636 , B01L2200/146 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , B01L2400/082 , F16K99/0017 , F16K99/0026 , F16K99/0055 , Y10T436/2575
摘要： Articles and methods for controlling flow in fluidic Systems, especially in microfluidic Systems, are provided. A microfluidic System includes a configuration such that the actuation of a single valve can allow the switching of fluids from a first fluid path (e.g., a first channel section) to a second fluid path (e.g., a second channel section). This may be achieved by incorporating a valve (38) with a first channel section (24), which may have a lower hydrodynamic resistance than a second channel section (28)prior to actuation of the valve. Actuation of the valve (38) can cause only the hydrodynamic resistance of the first channel section (24) to increase, thereby redirecting fluid flow into the second channel section (28) (which now has a relatively lower hydrodynamic resistance). The valve comprises a control channel (40) for introducing a positive or reduced pressure, and is adapted to modulate fluid flow in an adjacent channel section by constricting or expanding the channel section (24).
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公开(公告)号：EP2004316B1
公开(公告)日：2010-10-13
申请号：EP07717014.0
申请日：2007-01-24
CPC分类号： B01F13/0071 , B01F13/0076 , B01J19/0093 , B01J2219/00272 , B01J2219/00828 , B01J2219/00833 , B01J2219/00835 , B01J2219/00853 , B01J2219/00889 , B01J2219/0093 , B01L3/5027 , B01L3/502784 , B01L2200/0673 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , G01N15/1404 , G01N2015/1006
摘要： The present invention relates to a method, comprising: providing a microfluidic system comprising one or more channels (25,28,29); providing within said one or more channels (25,28,29) a first fluidic stream and a second fluidic stream, at least one of which comprises droplets that have an average diameter of less than about 450 microns and that are highly monodisperse; and applying an electric field (40) simultaneously to at least a portion of the first fluidic stream and a portion of the second fluidic stream such that said portions coalesce.
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公开(公告)号：EP2183408A2
公开(公告)日：2010-05-12
申请号：EP08795101.8
申请日：2008-08-07
发明人： WEITZ, David, A. , HOLTZE, Christian , ABATE, Adam, R. , LEE, Daeyeon , DO, Thao
IPC分类号： C23C18/12
CPC分类号： C23C18/1295 , C03C1/008 , C23C18/1216 , C23C18/1233 , C23C18/1254 , Y10T428/2457 , Y10T428/24612 , Y10T428/24744
摘要： The present invention provides a method for coating metal oxide on a PDMS surface. The method includes preparing a mixture that contains a sol-gel precursor, reacting the mixture to form a preconverted sol-gel precursor, where the preconverted sol-gel precursor does not diffuse into PDMS and is not in the form of a gel, forming a reactive PDMS surface, applying the preconverted sol-gel precursor onto the reactive PDMS surface, binding the preconverted sol-gel precursor to the reactive PDMS surface, and converting the bound preconverted sol-gel precursor to a metal oxide to form a metal oxide coating on the PDMS surface. The present invention also provides a PDMS microfiuidic device where one or more channels of the microfluidic device is provided with a metal oxide coating covalently bound only on the surface of the one or more channels.
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公开(公告)号：EP1610888A2
公开(公告)日：2006-01-04
申请号：EP04759306.6
申请日：2004-04-09
CPC分类号： B01L3/502784 , B01F5/0682 , B01F13/0062 , B01F13/0071 , B01F13/0076 , B01F2215/0431 , B01J2/04 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2300/0867 , B01L2400/02 , B01L2400/0415 , B01L2400/0424 , B05B5/03 , B05B7/061
摘要： This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.
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公开(公告)号：EP2941642B1
公开(公告)日：2020-05-13
申请号：EP13870350.9
申请日：2013-11-20
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公开(公告)号：EP3134536B1
公开(公告)日：2019-12-18
申请号：EP15783629.7
申请日：2015-04-17
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