公开(公告)号：EP0789842A4

公开(公告)日：2004-08-04

申请号：EP95937232

申请日：1995-11-03

申请人： A2 CORP LTD ,  NEW ZEALAND DAIRY BOARD

发明人： ELLIOTT ROBERT BARTLETT ,  HILL JEREMY PAUL

IPC分类号： A23C9/20 ,  C12Q1/68 ,  G01N33/04 ,  G01N33/68 ,  A01K67/02

CPC分类号： G01N33/6848 ,  A23C9/20 ,  C12Q1/6876 ,  C12Q2600/124 ,  C12Q2600/156 ,  G01N33/04 ,  G01N33/68

摘要： The invention is based on the discovery that certain variants of beta -casein may induce Type-1 diabetes in susceptible individuals while other variants do not. The invention consists of the selection of non-diabetogenic milk producing cows and recovering and processing their milk and milk products. Another aspect of the invention is selectively breeding cows which produce the non-diabetogenic milk.

公开(公告)号：EP1106077A1

公开(公告)日：2001-06-13

申请号：EP00870235.9

申请日：2000-10-19

申请人： Interagri 2001 S.A.

发明人： VanVolsem, Thibaut

IPC分类号： A23K1/14 ,  A23K1/18 ,  A23C9/14 ,  A23K1/00

CPC分类号： A23C9/20 ,  A23C2230/10 ,  A23K40/20 ,  A23K40/25 ,  A23K50/10

摘要： Lait de vache dont le spectre d'acides gras, déterminé par chromatographie en phase gazeuse, est changé par rapport au lait classique, ce lait étant obtenu par une alimentation de la vache comprenant l'ajout à la ration de base quotidienne, d'un aliment à base de graines de lin extrudées

摘要翻译： 使用气相色谱分析的牛奶含有特定量的己酸，辛酸，癸酸，月桂酸，肉豆蔻酸，棕榈酸，硬脂酸，疫苗，油酸，亚油酸，9,12-反亚麻酸，9， 12,15-顺式亚麻酸和共轭顺式-9-反式-118C脂肪酸。 使用气相色谱分析的牛奶含有（每100g脂肪酸）1.7-2.7g己酸，1-1.6g辛酸，1.6-4.2g癸酸，2.8-4.25g月桂酸，10.5-13g肉豆蔻酸，23.9 -31.6g棕榈酸，12.5-17.4g硬脂酸，2.5-6g疫苗，24-29g油酸，1.6-3.9g亚油酸，0.5-1.0g 9,12-反亚麻酸，0.6-1.2g 9,12,15-顺式亚麻酸和0.7-3.35g缀合的顺式-9-反式-118C脂肪酸。 该乳含有60.3-68.15g饱和脂肪酸，40-51g长链（至少18C）脂肪酸，32.85-39.7g不饱和脂肪酸，28.68-39.2g单不饱和脂肪酸和3.15-4.65g多不饱和脂肪酸 ，16C饱和：18C单不饱和脂肪酸和OMEGA 6与OMEGA 3的比例分别为0.68-1.2和2.5-5。 独立权利要求包括：（1）由该奶制成的产品，（2）至少包含挤出亚麻籽颗粒的奶牛饲料，（3）涉及使用该饲料的奶牛的喂养过程，以及（4）饲料的生产 涉及挤压在80-130摄氏度

公开(公告)号：EP0861897A3

公开(公告)日：1999-05-12

申请号：EP98200772.6

申请日：1991-04-04

申请人： Oklahoma Medical Research Foundation

发明人： Tang, Jordan J N ,  Wang, Chi-Sun

IPC分类号： C12N15/55 ,  C12N9/18 ,  A01K67/027

CPC分类号： A23C9/20 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/10 ,  A01K2267/01 ,  A23C9/1216 ,  A23L33/17 ,  C12N9/18 ,  C12N15/8509 ,  C12Y301/01003

摘要： The complete structure of human milk BAL cDNA is disclosed. The nucleotide sequences of the cDNA inserts of two clones overlap and together contain 2951 base pairs of BAL cDNA which codes for an open reading frame of 720 amino acid residues between initiation and termination codons. There is a putative signal sequence of 20 residues which is followed by a 61-amino-terminal sequence of BAL. The cDNA sequence also contains a 678-base 5'-untranslated sequence, a 96-base 3'-untranslated region, and a 14-base poly(A) tail. The deduced BAL protein structure contains in the carboxyl-terminal region fourteen repeating units of 11 amino acids each. The repeating units have the basic structure of Pro-Val-Pro-Pro-Thr-Gly-Asp-Ser-Gly-Ala-Pro-, with only minor substitutions. The cDNA is useful for expression of protein, study of structure, function and the effect of modification or deletion or addition of amino acids, including entire repeating units, and as probes for studies involving BAL or related lipases, including rat pancreatic lysophospholipase, cholinesterase, and acetylcholinesterase.

公开(公告)号：EP0853890A4

公开(公告)日：1999-01-20

申请号：EP96931238

申请日：1996-09-18

申请人： MORINAGA MILK INDUSTRY CO LTD

发明人： HAYASAWA HIROTOSHI ,  TAKAHASHI KOUICHI ,  NANBA KAZUYOSHI ,  SHIMIZU TAKASHI ,  SAYAMA KOJI ,  SHIMIZU YOSUKE ,  ARITSUKA TSUTOMU ,  NAGURA TAIZO

IPC分类号： A23C9/152 ,  A23C9/156 ,  A23C9/18 ,  A23C9/20 ,  A23C11/04 ,  A23L1/30 ,  A61K35/20 ,  A61K36/48 ,  A61K38/00 ,  A23C9/00

CPC分类号： A23C9/156 ,  A23C9/1526 ,  A23C9/20 ,  A23C11/04 ,  Y10S426/801

摘要： The present invention provides the lactose-containing food compositions for infants for improving the stool color of infants closer to that of breast-fed infants, which comprises the lactose-containing foods for infants of which the only protein source is substantially cow's milk protein and/or a processed product of cow's milk protein modified to be administered to infants, and raffinose added into the foods for infants at a ratio of at least 0.05% (by weight) in a ready-to-use state. This food composition provides foods for infants more suitable for infant growth (infant formula, protein hydrolyzed formula, formula for low-birth-weight infants, follow-up formula, etc.) without causing a green stool which is observed when administering a conventional food for sucking infants, of which the only protein source is substantially cow's milk protein and/or a processed product of cow's milk protein.

公开(公告)号：EP0888112A1

公开(公告)日：1999-01-07

申请号：EP97914690.0

申请日：1997-03-04

申请人： Wiklund, Lars

发明人： Wiklund, Lars

IPC分类号： A23C11 ,  A23C9 ,  A23L1 ,  A61K31 ,  A61K33 ,  A61P3 ,  G01N33

CPC分类号： A23C9/20 ,  A23L33/16 ,  A61K31/17 ,  A61K33/02 ,  G01N33/62 ,  Y10S297/08

摘要： The use of a physiologically innocuous ammonium compound and/or urea as an additive to an infant formula or a pap or for the preparation of a pharmaceutical composition for the prophylaxis of sudden infant death syndrome (SIDS) is disclosed as is also an infant formula or a pap which in addition to conventional ingredients contains a physiologically innocuous ammonium compound and/or urea. Furthermore, a method of preventing SIDS is disclosed, which method comprises administering to the infant an infant formula or a pap as indicated above, and a method for the prophylaxis of SIDS, wherein a pharmaceutical composition containing a physiologically innocuous ammonium compound and/or urea is administered to the infant or the appropriately selected or modified non-pathogenic, urease-producing bacteria are supplied to the gastrointestinal tract of the infant. Finally a method for the diagnosis of the risks for SIDS is disclosed according to which method the faeces of the infant are analyzed with respect to the presence of urea, urease activity and/or ammonium ions, the presence of urea, the absence or abnormally low urease activity and ammonium ion, respectively, indicating risks for SIDS.

公开(公告)号：EP0871366A1

公开(公告)日：1998-10-21

申请号：EP96912338.0

申请日：1996-05-09

申请人： McLachlan, Corran Norman Stuart

发明人： McLachlan, Corran Norman Stuart

IPC分类号： A01K67 ,  A23C9 ,  A23G9 ,  A23J1 ,  A23L1

CPC分类号： A23G9/40 ,  A01K67/027 ,  A23C9/20 ,  A23J1/202 ,  A23L13/00 ,  A23L13/20 ,  A23L33/19

摘要： A milk or other dairy product, capable of minimising the onset of disease such as coronary heart disease or enhancing the immune response is derived from animals which are substantially free of the β-casein A1 allele. Bulk milk can be produced by testing for and culling cows who test positive for the β-casein A1 allele, or by producing immunoglobulins and other immune response proteins, in cow's milk from animals not possessing the β-casein A1 allele, or other commercial milk pruducing animals, to this allele, to counteract the immunosuppressant substances present that are produced from it, in commercial milking cows such as Holsteins, together with its blending with non-treated milk or the recovery of such immunoproteins.

公开(公告)号：EP0866676A1

公开(公告)日：1998-09-30

申请号：EP96938234.0

申请日：1996-11-11

申请人： Aaltonen, Antti Sakari ,  Suhonen, Jouko

发明人： Aaltonen, Antti Sakari ,  Suhonen, Jouko

IPC分类号： A23C9 ,  A61C19 ,  A61J7 ,  C07K16 ,  A61J17

CPC分类号： A61C19/06 ,  A23C9/20 ,  A61J7/0053 ,  A61J7/0092 ,  A61J17/001 ,  A61J17/006 ,  C07K16/04 ,  C07K16/1217 ,  C07K16/1242 ,  C07K16/1275

摘要： The object of the invention is an intraoral administration device comprising an elongated, substantially plate-like arcuate oral screen designed to conform to the teeth and intended to be accommodated in the space between the theeth and the lips. The device is characterized in that the oral screen (7, 17) comrpises containers (9) for the agent to be administered intraorally, which containers are provided with means such as holes or apertures (5) allowing the free entrance of saliva into the container and its exit therefrom. The invention is also directed on an administration system comprising the administration device and an active agent, such as for example an agent against caries or otitis media.

公开(公告)号：EP0832981A1

公开(公告)日：1998-04-01

申请号：EP97203192.6

申请日：1988-02-10

申请人： Pharming B.V.

发明人： Rosen, Jeffrey M.

IPC分类号： C12N15/85 ,  A01K67/027

CPC分类号： A01K67/0275 ,  A01K67/02 ,  A01K2217/05 ,  A01K2217/20 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2227/108 ,  A01K2267/01 ,  A23C9/20 ,  A23C2230/05 ,  C07K14/4732 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/61 ,  C12N9/1033 ,  C12N15/85 ,  C12N15/8509 ,  C12N15/89 ,  C12N2830/008 ,  C12N2830/42 ,  C12N2830/85

摘要： The invention provides the use of an enhancer sequence in effecting targeted mammary gland expression in a transgenic non-human mammal of a coding sequence derived from a gene coding for a biologically active agent, said enhancer sequence being employed, together with said coding sequence, in the form of a recombinant DNA gene complex incorporated into the germ line of said mammal.

摘要翻译： 本发明提供增强子序列用于在转基因非人哺乳动物中实现来自编码生物活性剂的基因的编码序列的靶向乳腺表达的用途，所述增强子序列与所述编码序列一起被用于 结合到所述哺乳动物的种系中的重组DNA基因复合物的形式。

公开(公告)号：EP0611525B1

公开(公告)日：1997-03-19

申请号：EP93420484.3

申请日：1993-12-07

申请人： COMPAGNIE EUROPEENNE DE DIFFUSION DE PRODUITS LACTES - CEDILAC SA

发明人： Balabaud, Christine ,  Loones, Alain

IPC分类号： A23C9/154 ,  A23C11/04 ,  A23C9/20

CPC分类号： A23C9/20 ,  A23C9/1544 ,  A23C11/04

公开(公告)号：EP0746329A1

公开(公告)日：1996-12-11

申请号：EP93922286.0

申请日：1993-09-22

申请人： STOLLE RESEARCH & DEVELOPMENT CORPORATION

发明人： BECK, Lee, R.

IPC分类号： A61K ,  A23C9 ,  A24B15 ,  A61K9 ,  A61K35 ,  A61K39 ,  A61P29 ,  A61P37 ,  C07G99

CPC分类号： A23C9/20 ,  A24B15/30 ,  A61K9/1647 ,  A61K35/20 ,  A61K39/39508 ,  C07K2317/11

摘要： The invention relates to an anti-inflammatory factor isolated from milk and to methods for using this factor to remove adhered neutrophils from endothelial cells, to prevent the emigration of cells from the vasculature and to suppress the response of lymphocytes to foreign antigens.

摘要翻译： 本发明涉及从乳中分离的抗炎因子以及使用该因子从内皮细胞去除粘附的嗜中性粒细胞，防止细胞从脉管系统中迁移并抑制淋巴细胞对外来抗原的应答的方法。