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    IDENTIFICATION OF A DNA VARIANT ASSOCIATED WITH ADULT TYPE HYPOLACTASIA
    54.
    发明授权
    IDENTIFICATION OF A DNA VARIANT ASSOCIATED WITH ADULT TYPE HYPOLACTASIA 有权
    鉴定所获得的乳糖不耐受相关的DNA变体的

    公开(公告)号：EP1417305B1

    公开(公告)日：2012-07-18

    申请号：EP02794596.3

    申请日：2002-08-09

    申请人： National Public Health Institute

    发明人： PELTONEN, Leena National Public Health Institute ,  ENATTAH, Nabil National Public Health Institute ,  JÄRVELÄ, Irma National Public Health Institute ,  SAHI, Timo ,  SAVILAHTI, Erkki ,  TERWILLIGER, Joseph Columbia University, Dept. of

    IPC分类号： C12N15/00

    CPC分类号： C12Y302/01062 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C12N9/2402 ,  C12N9/2468 ,  C12N9/2471 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Y302/01023 ,  C12Y302/01108

    摘要： The present invention relates to a nucleic acid molecule comprising a 5' portion of an intestinal lactase-phlorizine hydrolase (LPH) gene contributing to or indicative of the adult-type hypolactasia wherein said nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule having or comprising the nucleic acid sequence of SEQ ID NO: 1, the sequence of SEQ ID NO:1 is also depicted in the Fig. 4 and comprised in the sequence as depicted in the Fig. 8; (b) a nucleic acid molecule having or comprising the nucleic acid sequence of SEQ ID NO: 2, the sequence of SEQ ID NO:2 is also depicted in Fig.5 and comprised in the sequence as depicted in the Fig. 9; (c) a nucleic acid molecule of at least 20 nucleotides the complementary strand of which hybridizes under stringent conditions to the nucleic acid molecule of (a) or (b), wherein said polynucleotide/nucleic acid molecule has at a position corresponding to position -13910 5' from the LPH gene a cytosine residue; and (d) a nucleic acid molecule of at least 20 nucleotides the complementary strand of which hybridizes under stringent conditions to the nucleic acid molecule of (a) or (b), wherein said polynucleotide/nucleic acid molecule has at a position corresponding to position -22018 5' from the LPH gene a guanine residue. The present invention further relates to methods for testing for the presence of or predisposition to adult-type hypolactasia that are based on the analysis of an SNP contained in the above recited nucleic acid molecule. Additionally, the present invention relates to diagnostic composition and kit useful in the detection of the presence of or predisposition to adult-type hypolactasia.

    AGARASE AND GENE THEREOF
    57.
    发明公开
    AGARASE AND GENE THEREOF 有权
    AGARASE UND GENDAFÜR

    公开(公告)号：EP1365025A1

    公开(公告)日：2003-11-26

    申请号：EP02700773.1

    申请日：2002-02-26

    申请人： TAKARA BIO INC.

    发明人： TOMONO, Jun, 313, Hamoparesu-Kusatsu, 12-1 ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

    IPC分类号： C12N15/56 ,  C12N9/38 ,  C12N9/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P19/14

    CPC分类号： C12Y302/01081 ,  C12N9/2468

    摘要： Production of efficiently producing agaro-oligosaccharide; a polypeptide having an agarase activity which is usable in, for example, efficiently extracting a substance such as a nucleic acid from an agarose gel; the amino acid sequence of the polypeptide; a gene encoding the polypeptide; a process for producing the polypeptide; a process for producing agaro-oligosaccharide; and a process for extracting a substance such as a nucleic acid from an agarose gel.

    摘要翻译： 有效生产琼脂寡糖的生产; 具有琼脂糖酶活性的多肽，其可用于例如从琼脂糖凝胶中有效地提取诸如核酸的物质; 多肽的氨基酸序列; 编码该多肽的基因; 制备多肽的方法; 一种生产琼脂寡糖的方法; 以及从琼脂糖凝胶中提取核酸等物质的方法。