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    COMPOUND CONTAINING INDOLEACETIC ACID CORE STRUCTURE AND USE THEREOF
    57.
    发明公开
    COMPOUND CONTAINING INDOLEACETIC ACID CORE STRUCTURE AND USE THEREOF 审中-公开
    含有吲哚乙酸核心结构的化合物及其用途

    公开(公告)号：EP3252039A1

    公开(公告)日：2017-12-06

    申请号：EP16742705.3

    申请日：2016-01-25

    申请人： Beijing An Jian Xi Bio-Medical Technology Co., Ltd

    发明人： Beijing An Jian Xi Bio-Medical Technology Co., Ltd

    IPC分类号： C07D209/26 ,  C07C317/44 ,  A61K31/405 ,  A61K31/216 ,  A61P35/00 ,  A61P35/02 ,  A61P29/00

    CPC分类号： C07D209/26 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/216 ,  A61K31/337 ,  A61K31/405 ,  A61K31/635 ,  A61K31/661 ,  A61K31/704 ,  A61K45/06 ,  C07C317/44 ,  C07C2602/08

    摘要： Disclosed are a compound as shown by the following formula 1, and a pharmaceutically acceptable salt, an ester, a hydrate and an organic solvate thereof. In the formula (1), the groups R 1 to R 17 are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, carbonyl, hydroxyl, amino, azido, carboxyl and C 1 -C 8 alkylsulfinyl, respectively; and X is a carbon or nitrogen atom; Y is selected from the following groups: a single bond, C 1 -C 8 alkylene, C 6 -C 20 arylene and C 4 -C 20 heteroarylene; and n is an integer from 5 to 20. Also provided in the present invention are a pharmaceutical composition containing the compound, and use thereof in the field of tumor therapy.

    摘要翻译： 公开了如下式1所示的化合物及其药学上可接受的盐，酯，水合物和有机溶剂化物。 在式（1）中，基团R 1至R 17独立地选自氢，氟，氯，溴，碘，C 1 -C 8烷基，C 1 -C 8烷氧基，羰基，羟基，氨基，叠氮基，羧基和 C1-C8烷基亚磺酰基; X是碳或氮原子; Y选自以下基团：单键，C1-C8亚烷基，C6-C20亚芳基和C4-C20杂亚芳基; n为5-20的整数。本发明还提供了含有该化合物的药物组合物及其在肿瘤治疗领域的用途。

    AGING INHIBITOR
    59.
    发明公开
    AGING INHIBITOR 审中-公开
    老化抑制剂

    公开(公告)号：EP3231437A1

    公开(公告)日：2017-10-18

    申请号：EP15868543.8

    申请日：2015-12-01

    申请人： Nihon Sizen Hakkoh Co., Ltd.

    发明人： HIGASHI Naoki ,  NAKANISHI Masahiro

    IPC分类号： A61K36/07 ,  A61K31/19 ,  A61K31/192 ,  A61K31/194 ,  A61K31/196 ,  A61K31/197 ,  A61K31/198 ,  A61K31/352 ,  A61K31/353 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A61K35/744 ,  A61K36/03 ,  A61K36/062 ,  A61K36/064 ,  A61K36/185 ,  A61K36/31 ,  A61K36/39 ,  A61K36/75

    摘要： An object of the present invention is to provide a senescence retarding agent that delays the onset of senescence symptoms and extends longevity, and is superior in safety. The senescence retarding agent of the present invention that achieves the object is characterized by containing a plant fermentation product as an active ingredient, the plant fermentation product being a mixture of the following: (a) a koji mold-fermented product of one or more kinds of beans and/or cereals selected from the group consisting of barley, black soybean, red rice, black rice, adzuki bean, adlay, Japanese millet, foxtail millet, and millet; (b) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of fruits selected from the group consisting of mikan (mandarin orange), grape, apple, yama-budo (crimson glory grape), peach, kaki (Japanese persimmon), papaya, nashi (Japanese pear), watermelon, ume (Japanese apricot), fig, karin (Chinese quince), pumpkin, kumquat, yuzu (Chinese lemon), loquat, apricot, jujube, chestnut, matatabi (silvervine), and sumomo (Japanese plum) ; (c) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of root crops and/or potatoes selected from the group consisting of murasaki-imo (purple sweet potato), kikuimo (Jerusalem artichoke), carrot, onion, satsuma-imo (sweet potato), satoimo (taro), jinenzyo (Japanese yam), daikon (Japanese radish), akakabu (red turnip), gobo (burdock root), renkon (lotus root), yacon, yuri-ne (lily bulb), kuwai (arrowhead), ginger, garlic, and turmeric; (d) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of flowers and/or leaf vegetables selected from the group consisting of cabbage, shiso (perilla), mulberry leaves, dokudami (Korean houttuynia), yomogi (wormwood), kumazasa (kuma bamboo grass), and dandelion; (e) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seaweeds selected from the group consisting of kombu (sea tangle), wakame (Undaria pinnatifida), and mozuku (Nemacystus decipiens); (f) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seeds selected from the group consisting of black sesame seeds, walnuts, and ginkgo nuts; and (g) a yeast- and/or lactic acid bacterium-fermented product of one or two kinds of mushrooms selected from the group consisting of maitake (Grifola frondosa) and shiitake (Lentinus edodes).

    摘要翻译： 本发明的目的是提供延迟衰老症状的发生并延长寿命的衰老延缓剂，并且安全性优异。 实现该目的的本发明的衰老缓和剂的特征在于，含有植物发酵产物作为活性成分，所述植物发酵产物为以下物质的混合物：（a）一种或多种曲霉发酵物 选自大麦，黑大豆，红米，黑米，小豆，薏米，日本小米，谷子和小米的豆类和/或谷类; （b）一种或多种选自米坎（柑橘），葡萄，苹果，山茶花（绯红色荣耀葡萄），桃子，柿子（kaki）的果实的酵母和/或乳酸菌发酵产物 （日本柿子），番木瓜，日本梨，西瓜，梅（日本杏），无花果，karin（南瓜），南瓜，金橘，柚子（中国柠檬），枇杷，杏，枣，栗子，matatabi ）和sumomo（日本梅子）; （c）选自紫色甘薯，菊芋（菊芋），胡萝卜等的一种或多种作物和/或马铃薯的酵母和/或乳酸菌发酵物， 洋葱，萨摩-imo（红薯），satoimo（芋头），jinenzyo（日本山药），daikon（萝卜），akakabu（红萝卜），gobo（牛蒡根），renkon（莲藕），yacon，yuri-ne （百合鳞茎），kuwai（箭头），姜，大蒜和姜黄; （d）选自卷心菜，紫苏（紫苏），桑叶，dokudami（韩国鱼腥草），yomogi（日本鳗鱼）的一种或多种花和/或叶蔬菜的酵母和/或乳酸菌发酵产物 （苦艾），kumazasa（kuma竹草）和蒲公英; （e）选自海带（海带），裙带菜（Undaria pinnatifida）和mozuku（Nemacystus decipiens）的一种或多种海藻的酵母和/或乳酸菌发酵产物; （f）选自黑芝麻，核桃和银杏坚果中的一种或多种种子的酵母和/或乳酸菌发酵产物; 和（g）选自舞茸（灰树花）和香菇（香菇）的一种或两种蘑菇的酵母和/或乳酸菌发酵产物。

    AMINO ACID COMPOSITIONS FOR THE TREATMENT OF SYMPTOMS OF DISEASE
    60.
    发明公开
    AMINO ACID COMPOSITIONS FOR THE TREATMENT OF SYMPTOMS OF DISEASE 审中-公开
    用于治疗疾病症状的氨基酸组合物

    公开(公告)号：EP3223809A1

    公开(公告)日：2017-10-04

    申请号：EP15863301.6

    申请日：2015-11-19

    申请人： Entrinsic Health Solutions, Inc.

    发明人： VIDYASAGAR, Sadasivan ,  GATTO, Stephen, J. ,  DENNISON, Daniel, B.

    IPC分类号： A61K31/197 ,  A61K31/198 ,  A61K31/405 ,  A61P1/00

    CPC分类号： A61K31/198 ,  A61K31/00 ,  A61K31/197 ,  A61K31/405 ,  A61K2300/00

    摘要： The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of symptoms of a disease selected from the group consisting of: Ebola virus infection, HIV infection, ataxia, environmental enteropathy, cancer, hangover, inflammatory disease, and porcine epidemic diarrhea. In preferred embodiments, the composition includes a combination of one or more amino acids selected from the group comprising lysine, aspartic acid, glycine, isoleucine, threonine, tyrosine, valine, tryptophan, asparagine and/or serine.

    摘要翻译： 本发明提供治疗组合物及其用于治疗或改善选自以下的疾病的症状：埃博拉病毒感染，HIV感染，共济失调，环境肠病，癌症，宿醉，炎性疾病和猪流行性腹泻 。 在优选的实施方案中，组合物包含选自赖氨酸，天冬氨酸，甘氨酸，异亮氨酸，苏氨酸，酪氨酸，缬氨酸，色氨酸，天冬酰胺和/或丝氨酸的一种或多种氨基酸的组合。