公开(公告)号：EP4410370A3

公开(公告)日：2024-10-16

申请号：EP24165911.9

申请日：2015-05-26

申请人： Reponex Pharmaceuticals A/S

发明人： Heslet, Lars

IPC分类号： A61K38/19 ,  A61K31/728 ,  A61K31/7024 ,  A61P17/02 ,  A61P43/00

摘要： The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor (GM-CSF), sucrose octasulfate including salts thereof, and hyaluronic acid for the treatment, pre-emptive treatment or prophylaxis of ulcers, wounds and other injuries to the skin or membranes of the body. Other aspects of the invention are methods of treatment or prevention using the compositions described, as well as an application device for use in the methods provided.

公开(公告)号：EP4389139A3

公开(公告)日：2024-10-16

申请号：EP24157036.5

申请日：2015-01-09

申请人： Bioverativ Therapeutics Inc.

发明人： CHHABRA, Ekta, Seth ,  LIU, Tongyao ,  PETERS, Robert T. ,  KULMAN, John

IPC分类号： A61K38/36

摘要： The present invention provides a chimeric protein comprising a first polypeptide which comprises a FVIII protein and a first Ig constant region or a portion thereof and a second polypeptide which comprises a VWF protein comprising the D' domain and D3 domain of VWF, a XTEN sequence having less than 288 amino acids in length, and a second Ig constant region or a portion thereof, wherein the first polypeptide and the second polypeptide are associated with each other. The invention also includes nucleotides, vectors, host cells, methods of using the chimeric proteins.

公开(公告)号：EP4442698A1

公开(公告)日：2024-10-09

申请号：EP22914735.0

申请日：2022-12-27

申请人： Chengdu Origen Biotechnology Co., Ltd.

发明人： KE, Xiao ,  ZHENG, Qiang ,  LUO, Shuang ,  JIANG, Hao

IPC分类号： C07K14/015 ,  C12N7/00 ,  C12N15/35 ,  C12N15/864 ,  A61K48/00 ,  A61K38/00 ,  A61K35/76 ,  A61P27/02 ,  A61P19/02

CPC分类号： A61K35/76 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/00 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/06 ,  A61P27/06 ,  A61P29/00 ,  A61P27/02 ,  C07K14/015 ,  C12N7/00 ,  C12N15/864

摘要： The present invention relates to a modified adeno-associated virus (AAV) capsid protein and use thereof; said capsid protein comprises substitution of approximately 5-14 amino acids with respect to a parent AAV capsid protein; furthermore, the AAV containing the modified capsid protein has increased infectiousness with respect to a target tissue or target cell (e.g. retinal cell) in comparison with an AAV comprising an unmodified parent AAV capsid protein.

公开(公告)号：EP4442269A1

公开(公告)日：2024-10-09

申请号：EP22900342.1

申请日：2022-11-23

申请人： Seinda Pharmaceutical Guangzhou Corporation

发明人： HUANG, Jingfeng ,  LIU, Yanan ,  DU, Tieliang

IPC分类号： A61K38/05 ,  A61K9/10 ,  A61K9/08 ,  A61P27/02 ,  A61P27/10

CPC分类号： A61K9/10 ,  A61P27/10 ,  A61K38/05 ,  A61P27/02 ,  A61K9/08

摘要： A use of alanyl-glutamine in preparation for a drug for treating, relieving or alleviating ocular surface diseases and/or conditions of non-dry eyes. A use of alanyl-glutamine in preparation for a drug for relieving or alleviating visual fatigue. A use of alanyl-glutamine in preparation for a beauty product and health-care product for relieving or alleviating asthenopia.

公开(公告)号：EP4442268A2

公开(公告)日：2024-10-09

申请号：EP24180271.9

申请日：2018-10-09

申请人： Alpine Immune Sciences, Inc.

发明人： Evans, Lawrence ,  Kuijper, Joseph L. ,  Swanson, Ryan

IPC分类号： A61K38/00

CPC分类号： A61K38/00 ,  C07K14/70521 ,  C07K2319/3020130101 ,  C12N5/0637

摘要： Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.

公开(公告)号：EP4441088A2

公开(公告)日：2024-10-09

申请号：EP22902417.9

申请日：2022-12-02

申请人： Texas Tech University System

发明人： SUTTON, Roger, B. ,  HIRSCH, Matthew

IPC分类号： C07K14/74 ,  A61K38/17 ,  C12N15/63 ,  C12N15/85 ,  C07K14/08

CPC分类号： C07K14/70539 ,  C07K2319/0020130101

公开(公告)号：EP4441067A1

公开(公告)日：2024-10-09

申请号：EP22899364.8

申请日：2022-11-23

申请人： Merck Sharp & Dohme LLC ,  MSD International GmbH ,  Agency for Science, Technology and Research

发明人： JOSIEN, Hubert ,  CHANDRAMOHAN, Arun ,  JOHANNES, Charles, William ,  BROWN, Christopher, J. ,  KANNAN, Srinivasaraghavan ,  PARTRIDGE, Anthony, W. ,  VERMA, Chandra Shekhar ,  YAN, Lin ,  YUEN, Tsz Ying

IPC分类号： C07K4/00 ,  A61K38/03 ,  A61P35/00 ,  A61K38/12 ,  C07K7/64

CPC分类号： A61K38/03 ,  A61P35/00 ,  C07K7/08 ,  C07K14/001 ,  A61K38/00

公开(公告)号：EP4440644A2

公开(公告)日：2024-10-09

申请号：EP22830701.3

申请日：2022-12-02

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université Paris Cité ,  Université Paris XIII Paris-Nord

发明人： CALIGIURI, Giuseppina ,  NICOLETTI, Antonino ,  SKARBEK, Charles ,  BIANCHI, Elisabetta ,  INGENITO, Raffaele

IPC分类号： A61L31/00 ,  A61K38/00 ,  A61P9/10 ,  C07K14/705

CPC分类号： A61K38/00 ,  A61P9/10 ,  C07K14/705 ,  A61L31/10 ,  A61L27/54 ,  A61L31/16 ,  A61L27/34 ,  A61L2300/2520130101

公开(公告)号：EP4440643A2

公开(公告)日：2024-10-09

申请号：EP22829836.0

申请日：2022-12-02

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université Paris Cité ,  Université Paris XIII Paris-Nord ,  Alchimedics

发明人： CALIGIURI, Giuseppina ,  NICOLETTI, Antonino ,  SKARBEK, Charles ,  LEFEVRE, Isabelle ,  BUREAU, Christophe

IPC分类号： A61L31/00 ,  A61K38/00 ,  A61P9/10 ,  C07K14/705

CPC分类号： A61K38/00 ,  A61P9/10 ,  C07K14/705 ,  A61L31/10 ,  A61L27/54 ,  A61L31/16 ,  A61L27/34 ,  A61L2300/2520130101

公开(公告)号：EP4440633A1

公开(公告)日：2024-10-09

申请号：EP22843558.2

申请日：2022-11-11

申请人： Baxter International Inc. ,  BAXTER HEALTHCARE SA

发明人： DELMOTTE, Yves

IPC分类号： A61L24/04 ,  A61K38/48 ,  A61L24/10 ,  A61P7/04

CPC分类号： A61L2400/0420130101 ,  A61L24/106 ,  A61L24/10 ,  A61L24/043 ,  A61K38/4833 ,  A61P7/04 ,  A61K35/08 ,  A61K38/014 ,  A61K9/0019