公开(公告)号：EP1372709A2

公开(公告)日：2004-01-02

申请号：EP02720132.6

申请日：2002-03-26

申请人： Imperial College Innovations Limited

发明人： FRANKEL, Gadi ,  DOUGAN, Gordon

IPC分类号： A61K39/108 ,  A61K39/40 ,  A23C9/00 ,  A23K1/00 ,  A61P31/04

CPC分类号： C07K14/245 ,  A61K38/00 ,  A61K39/00

摘要： A pharmaceutical composition, vaccine, food product or kit of parts comprising a polypeptide or polypeptides and/or polynucleotide or polynucleotides in combination comprising or encoding a polypeptide or polypeptides in combination comprising at least two of (1) α-intimin or a fragment thereof, (2) β-intimin or a fragment thereof, (3) Ϝ-intimin or a fragment thereof, (4) δ-intimin or a fragment thereof, and (5) ϵ-intimin or a fragment thereof, together with a pharmaceutically acceptable diluent or carrier, wherein the polypeptide or polypeptides do not consist of the Gly387 to Lys66 region, or a fragment thereof, of two or more intimins. Vaccination with the Gly387 to Lys666 region, which is conserved between different intimin types, is not considered to confer protective immunity. A combination vaccine may provide such protective immunity and may be useful in providing protection against bacterial infection.

公开(公告)号：EP1349570A1

公开(公告)日：2003-10-08

申请号：EP02726978.6

申请日：2002-01-03

申请人： The University of Saskatchewan ,  University of British Columbia

发明人： FINLAY, Brett ,  POTTER, Andrew, A.

IPC分类号： A61K39/108 ,  C07K14/245 ,  C12N1/20 ,  A61P31/04 ,  A61K39/39 ,  C07K1/02 ,  C07K1/34

CPC分类号： A61K39/0258 ,  A61K2039/55566 ,  C07K14/245 ,  Y02A50/474

摘要： Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.

公开(公告)号：EP1342784A1

公开(公告)日：2003-09-10

申请号：EP02290556.6

申请日：2002-03-06

申请人： Mutabilis S.A.

发明人： Escaich, Sonia

IPC分类号： C12N15/31 ,  C12N15/63 ,  C07K14/245 ,  C07K16/12 ,  A61K39/108 ,  G01N33/53

CPC分类号： C07K14/245

摘要： The invention relates to isolated antigenic polypeptides obtainable by a process comprising the steps of:

1- selecting on the basis of sequence analysis those of the polypeptides which are either located in the outermembrane or secreted by the bacteria,
2- identifying the genes coding for said polypeptides which are conserved in B2/D clinical isolates,
3- purifying the polypeptides identified in step 1, which are found in step 2 to be conserved in B2/D isolates,
4- testing the polypeptides for immunogenicity using animals models.

Application for making vaccines compositions.

摘要翻译： 本发明涉及通过包括以下步骤的方法获得的分离的抗原多肽：1-选择基于序列分析的位于外膜中或由细菌分泌的多肽的序列分析，2-鉴定编码所述 在B2 / D临床分离物中保守的多肽，3-纯化在步骤2中鉴定的多肽，其在步骤2中发现以在B2 / D分离物中保守，4-使用动物模型测试多肽的免疫原性。 制备疫苗组合物的申请。

公开(公告)号：EP0716613B1

公开(公告)日：2003-07-09

申请号：EP94922799.5

申请日：1994-07-25

申请人： CSL LIMITED ,  THE UNIVERSITY OF NEW SOUTH WALES

发明人： DOIDGE, Christopher Vincent ,  LEE, Adrian

IPC分类号： A61K39/106 ,  A61K39/02 ,  A61K39/108

CPC分类号： A61K39/105 ,  A61K2039/521 ,  A61K2039/542 ,  A61K2039/55544

摘要： A method for the treatment of Helicobacter infection, preferably H. pylori infection in a mammalian host such as a human comprises administration to the infected host of an immunologically effective amount of one or more Helicobacter antigen(s), preferably in association with a mucosal adjuvant such as cholera toxin or E.coli heat labile toxin.

公开(公告)号：EP1280912A2

公开(公告)日：2003-02-05

申请号：EP01928715.0

申请日：2001-04-20

申请人： University of Maryland, Baltimore

发明人： ALTBOUM, Zeev ,  LEVINE, Myron, M. ,  BARRY, Eileen, M.

IPC分类号： C12N15/31 ,  C07K14/245 ,  C12N5/10 ,  A61K39/108

CPC分类号： C07K14/25 ,  A61K39/00 ,  A61K39/0258 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/543 ,  C07K14/245 ,  C07K14/255 ,  C12N15/70 ,  Y02A50/474

摘要： Compositions comprising products of the csa operon, an isolated nucleic acid encoding the csa operon or functional fragments thereof, purified polypeptide products of the csa operon or functional fragments thereof, methods of eliciting an immune response to these products, and methods of producing products of the csa operon are disclosed herein.

公开(公告)号：EP1222202A2

公开(公告)日：2002-07-17

申请号：EP00968795.5

申请日：2000-10-05

申请人： Active Biotech AB

发明人： HANDLEY, Harold, H. ,  HAAPARANTA, Tapio ,  EWALT, Karla, L.

IPC分类号： C07K14/28 ,  C07K14/245 ,  C07K14/25 ,  C07K14/235 ,  C12N15/31 ,  C12N5/10 ,  A61K39/106 ,  A61K39/112 ,  A61K39/10 ,  A61K39/108

CPC分类号： C07K14/245 ,  A61K39/00 ,  C07K14/235 ,  C07K14/25 ,  C07K14/28 ,  Y02A50/472

摘要： A recombinant AB5 B subunit protein including at least one mutation, wherein the mutation alters the number of amino acid residues available for chemical modification as compared to a wild type AB5 B subunit protein, and wherein said recombinant protein retains an effective target ligand bind affinity. For example, specifically designed mutations are produced in the cholera Toxin B subunit (CTB) such that it can still bind with high affinity to its receptor, Gm-1, but can be specifically covalently linked at lysines or cysteines to an immunogen or vaccine. The vaccine produced from this coupling is a mucosal vaccine which has high immunogenicity due to the interaction with the CTB. The vaccine can be produced inexpensively and easily. Alternatively, a technique is disclosed for treating CTB such that non-covalent coupling to a vaccine or immunogen can occur.

公开(公告)号：EP1194563A1

公开(公告)日：2002-04-10

申请号：EP00950385.5

申请日：2000-07-14

申请人： MEDIMMUNE, INC.

发明人： HULTGREN, Scott, J. ,  LANGERMANN, Solomon

IPC分类号： C12N15/31 ,  C07K14/245 ,  C07K16/12 ,  A61K39/108 ,  A61K39/40

CPC分类号： C12R1/19 ,  A61K39/00 ,  C07K14/245

摘要： Purified polypeptides formed from amino acid sequences corresponding to domains derived from the adhesin protein, FimH, are disclosed. Also disclosed are compositions containing these novel polypeptides for use as vaccines and for generating specific antibodies for use in treatment and/or prevention of diseases, such as urinary tract infections, caused by bacteria of the family enterobacteriaceae, from which FimH is derived.

公开(公告)号：EP1123711A1

公开(公告)日：2001-08-16

申请号：EP99949324.0

申请日：1999-10-20

申请人： THE KITASATO INSTITUTE

发明人： AIZAWA, Chikara, Res. Center for Biologicals ,  SUZUKI, Yuziro, Research Center for Biologicals ,  SATO, Taka-aki, Research Center for Biologicals ,  WATANABE, Koji, Research Center for Biologicals ,  HATTORI, Nobuaki, Research Center for Biologicals ,  TANAKA, Yoshitake, Research Center for Biologicals ,  OMURA, Satoshi, The Kitasato Institute

IPC分类号： A61K39/39 ,  A61K39/145 ,  A61K39/15 ,  A61K39/165 ,  A61K39/20 ,  A61K39/21 ,  A61K39/10 ,  A61K39/07 ,  A61K39/02 ,  A61K39/108 ,  A61K39/118 ,  A61K39/00 ,  A61K39/015 ,  A61K39/012 ,  A61K39/116 ,  A61K39/295 ,  A61P31/04 ,  A61P31/12 ,  A61P31/00

CPC分类号： A61K39/39 ,  A61K2039/543 ,  A61K2039/55544 ,  Y02A50/39 ,  Y02A50/412 ,  Y02A50/472

摘要： Described herein are adjuvants containing as the active ingredient an attenuated toxin having a residual activity of at least 1/2000 the activity of the natural toxin and vaccines containing such adjuvants. By using, for example, attenuated natural cholera toxin, vaccines capable of showing sufficient immune potentiation in percutaneous vaccination or nasal vaccination can be presented.

摘要翻译： 本文描述的是含有作为活性成分的减毒毒素的佐剂，其具有至少1/2000的天然毒素的活性和含有这些佐剂的疫苗的残留活性。 例如，通过使用减毒的天然霍乱毒素，可以提供能够在经皮疫苗接种或鼻腔疫苗接种中显示充分免疫增强作用的疫苗。

公开(公告)号：EP1080211A1

公开(公告)日：2001-03-07

申请号：EP99927745.2

申请日：1999-05-21

申请人： Active Biotech AB

发明人： CARLIN, Nils ,  LEBENS, Michael, R.

IPC分类号： C12N15/74 ,  C12N15/54 ,  C12N15/31 ,  C12N9/10 ,  C07K14/245 ,  C07K14/28 ,  C07K14/435 ,  A61K39/106 ,  A61K39/108

CPC分类号： C12N15/74 ,  A61K39/00 ,  C07K14/245 ,  C07K14/28 ,  C07K14/43559 ,  C12N9/1007 ,  Y02A50/423 ,  Y02A50/472

摘要： A method of producing a thy A - strain of vibrio cholerae comprising the step of site-directed mutagenesis in the V. cholerae chromosome at the locus of the thy A gene SEQ ID NO: 1 of FIG. 1 , is described. Particularly, a Delta thy A strain of Vibrio cholerae lacking the functionality of the thy A is disclosed. This strain may comprise one or several episomal autonomously replicating DNA elements, such as plasmids, having an optionally foreign, e.g. E. coli, functional thy A gene that enables the strain to grow in the absence of thymine in the growth medium, and optionally having a structural gene encoding a homologous or heterologous protein. Further, proteins encoded by a structural thy A gene and the 5'-flanking region are described as SEQ ID NO: 4 of FIG. 4 and SEQ ID NO: 5 of FIG. 5 , respectively. Additionally, a vaccine comprising a Vibrio cholerae Delta thy A strain of the invention or a thy A - strain of Vibrio cholerae produced by the method of the invention is disclosed.

公开(公告)号：EP1076567A1

公开(公告)日：2001-02-21

申请号：EP99924234.0

申请日：1999-05-14

申请人： Mkb Investments Limited Partnership

发明人： BRINTON, Marshall, K.

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  A61K39/10 ,  A61K39/102 ,  A61K39/108 ,  A01N63/00 ,  C12N1/00 ,  C12N1/36

CPC分类号： A61K39/099 ,  A61K39/0216 ,  A61K39/0258 ,  A61K39/102 ,  A61K2039/542 ,  A61K2039/552 ,  Y02A50/474

摘要： The present invention is directed to vaccine compositions and methods for immunizing poultry. The vaccine compositions comprise inactivated bacterial organisms which can be administered to the poultry through oral intake of water.