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公开(公告)号：EP4023750A1
公开(公告)日：2022-07-06
申请号：EP22157008.8
申请日：2014-07-01
IPC分类号： C12N7/01 , C12N15/70 , C12N15/74 , A61P1/00 , G01N33/569
摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
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公开(公告)号：EP3994153A2
公开(公告)日：2022-05-11
申请号：EP20834908.4
申请日：2020-06-30
申请人： Codexis, Inc.
IPC分类号： C07K14/195 , C12N9/12 , C12N15/70 , C12N15/74
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54.发明公开
公开(公告)号：EP3987031A1
公开(公告)日：2022-04-27
申请号：EP20826065.3
申请日：2020-06-19
申请人： Glycom A/S
发明人： PEDERSEN, Margit
IPC分类号： C12N15/113 , C12N15/70
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55.发明公开
公开(公告)号：EP3986432A1
公开(公告)日：2022-04-27
申请号：EP20825572.9
申请日：2020-06-19
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公开(公告)号：EP3974523A1
公开(公告)日：2022-03-30
申请号：EP21193067.2
申请日：2017-11-15
发明人： HONG, Hao , JAMES, Gage , LU, Jiangping , XU, Xingfu , YU, Wenyan , HUANG, Xin , MA, Yulei , CHENG, Yibing
摘要： A transaminase mutant and use hereof, the transaminase mutant having the SEQ ID NO: 1 with one or more amino acid mutations selected from the group consisting of: R416A/C/H/Q/T/S, R416A/C/H/Q/T/S+A417S, R416A/C/H/Q/T/S+C418A/Q/S, R416A/C/H/Q/T/S+ F89Y/W, R416A/C/H/Q/T/S+A417S+ F89Y/W, wherein "/" stands for "or. The enzymatic activity and/or stability of the transaminase mutant is improved.
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公开(公告)号：EP3954768A3
公开(公告)日：2022-02-23
申请号：EP21190849.6
申请日：2021-08-11
发明人： WANG, Yong , LV, Huajun , ZHANG, Ying , SHAO, Jie , LIU, Haili
摘要： The disclosure provides an engineering bacterium for ferulic acid production, a preparation method of the bacterium and use thereof. The invention provides an engineering bacterium that can efficiently produce ferulic compounds by expressing a series of heterologous enzymes in a host cell through gene recombination technology. The expression system constructed by the invention has low metabolic background, strong heterologous expression ability and low cost. The system can synthesize the end product through relatively simple steps, and provide a new way for the industrial production of ferulic acid, intermediates or derivatives thereof.
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58.发明授权
公开(公告)号：EP3225690B1
公开(公告)日：2022-02-23
申请号：EP15862847.9
申请日：2015-09-01
发明人： WANG, Hengliang , SUN, Peng , WU, Jun , ZHU, Li , PAN, Chao , LIU, Bo , PENG, Zhehui , CHANG, Shaohong , GONG, Xin , FENG, Erling , WANG, Bin , ZENG, Ming
IPC分类号： C12N15/70 , C12N15/74 , C07K19/00 , A61K39/104 , A61K39/08 , A61K39/112 , A61P31/04
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59.发明公开
公开(公告)号：EP3943607A1
公开(公告)日：2022-01-26
申请号：EP21178702.3
申请日：2015-04-09
IPC分类号： C12P19/34 , C07H21/04 , C12N15/10 , C12N15/70 , C07K14/295 , C07K14/405 , A01H1/00
摘要： A recombinantly expressed nucleotide triphosphate transporter efficiently imports the triphosphates of unnatural nucleotides into cells, and the endogenous cellular machinery incorporates those nucleotides into cellular nucleic acids. UBPs can therefore form within the cell's nucleic acids. Moreover, neither the presence of the unnatural triphosphates nor the replication of the UBP represents a significant growth burden. The UBP is not efficiently excised by nucleic acid repair pathways, and therefore can be retained as long as the unnatural triphosphates are available in the growth medium. Thus, the resulting cell is the first organism to stably propagate an expanded genetic alphabet.
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60.发明公开
公开(公告)号：EP3942079A1
公开(公告)日：2022-01-26
申请号：EP20728175.9
申请日：2020-03-18
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