公开(公告)号：EP2297207A1

公开(公告)日：2011-03-23

申请号：EP09766879.2

申请日：2009-06-19

申请人： Prothix BV

发明人： Hack, Erik

IPC分类号： C07K16/36

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to binding molecules such as antibodies that specifically bind plasma coagulation factor XI and that inhibit factor XI activation and/or activity. The factor XI-binding molecules of the invention may used in methods for preventing or treating diseases, disorders and/or conditions that are mediated by factor XI activation and/or wherein inhibition of factor XI has a beneficial effect.

摘要翻译： 本发明涉及结合分子，例如特异性结合血浆凝固因子XI并抑制因子XI激活和/或活性的抗体。 本发明的XI因子结合分子可用于预防或治疗由因子XI激活介导的疾病，病症和/或病症的方法和/或其中因子XI的抑制具有有益效果。

公开(公告)号：EP2097455A2

公开(公告)日：2009-09-09

申请号：EP07868632.6

申请日：2007-10-31

申请人： Genentech, Inc.

发明人： WU, Herren ,  SINGH, Sanjaya ,  FUNG, Sek, Chung ,  AN, Ling-ling ,  LOWMAN, Henry B. ,  KELLEY, Robert F.

IPC分类号： C07K16/36 ,  A61P37/00 ,  A61P27/02

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/50 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

公开(公告)号：EP1928911A2

公开(公告)日：2008-06-11

申请号：EP06793102.2

申请日：2006-08-31

申请人： Novo Nordisk Health Care AG

发明人： PINGEL, Hans, Kurt ,  NICOLAISEN, Else, Marie ,  KRARUP, Janus

IPC分类号： C07K16/00 ,  C07K16/36

CPC分类号： C07K16/36 ,  C07K2317/56 ,  C07K2317/565

摘要： The present invention relates to novel antibodies against FVII, use for determining amount of correctly folded and intact FVII in a sample, as well as for purification and process optimization.

公开(公告)号：EP1380653B1

公开(公告)日：2007-10-10

申请号：EP02705339.6

申请日：2002-03-19

申请人： Eisai R&D Management Co., Ltd.

发明人： ATSUMI, Tatsuya ,  KOIKE, Takao

IPC分类号： C12P21/08 ,  C12N15/00 ,  C12N5/10 ,  C07K16/36 ,  G01N33/53 ,  G01N33/577 ,  G01N33/86

CPC分类号： C07K16/40 ,  C07K16/36 ,  C07K2317/32 ,  G01N33/577 ,  G01N33/86

摘要： A monoclonal antibody which reacts with prothrombin forming a complex with phosphatidylserine but not with prothrombin forming no complex with phosphatidylserine; and a method of assaying an activity of a test plasma of inhibiting blood coagulation which involves: (1) the step of assaying the inhibitory activity of the test plasma on blood coagulation reaction and its inhibitory activity on the blood coagulation reaction; and (2) the step of comparing the inhibitory activity of the test plasma with the inhibitory activity of the antibody.

公开(公告)号：EP1832654A1

公开(公告)日：2007-09-12

申请号：EP05822796.8

申请日：2005-12-27

申请人： DAIICHI PURE CHEMICALS CO., LTD.

发明人： MATSUO, Masanao, Daiichi Pure Chemicals Co., Ltd. ,  EBINUMA, Hiroyuki, Daiichi Pure Chemicals Co., Ltd. ,  MIYAZAKI, Osamu, Daiichi Pure Chemicals Co., Ltd. ,  TANAKA, Kyoko, Daiichi Pure Chemicals Co., Ltd. ,  SUZUKI, Akiko, Daiichi Pure Chems. Co., Ltd.

IPC分类号： C12N15/02 ,  C07K16/36 ,  C12N5/10 ,  G01N33/53 ,  G01N33/577 ,  C12P21/08

CPC分类号： C07K16/18 ,  C07K14/745 ,  C07K14/75 ,  G01N33/86 ,  G01N2333/75 ,  G01N2800/224

摘要： The present invention is directed to a monoclonal antibody against a soluble fibrin, which specifically recognizes a conformation-changed site newly occurred in a C-terminal region of an Aα-chain of the soluble fibrin formed through thrombin digestion of fibrinogen. The present invention is also directed to a hybridoma which produces the antibody, an immunological assay method employing the antibody, and a method for evaluating hypercoagulability in a test sample by measuring the soluble fibrin level in the sample with the assay method. Through employment of the monoclonal antibody of the present invention, soluble fibrin on which plasmin has not acted, which reflects exclusively initial hypercoagulability, can be specifically detected.

摘要翻译： 本发明涉及针对可溶性血纤蛋白，其特异性识别的构象改变的位点新发生在A±通过纤维蛋白原的凝血酶消化所形成的可溶性纤维蛋白的 - 链式的C-末端区的单克隆抗体。 因此，本发明涉及一种杂交瘤产生的抗体，以免疫学测定方法用人抗体，并用于通过测量与测定方法在样品中的可溶性纤维蛋白水平的测试样品中评价高凝状态的方法。 通过采用本发明的单克隆抗体的，在其上纤溶酶可溶性纤维蛋白没有采取行动，这反映独占初始高凝状态，可以特异性地检测。

公开(公告)号：EP1780219A2

公开(公告)日：2007-05-02

申请号：EP06026900.8

申请日：1992-07-02

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： Griffin, John H. ,  Fernandez, Jose A.

IPC分类号： C07K14/745 ,  C07K16/36 ,  A61K38/17 ,  A61K39/395 ,  G01N33/543 ,  G01N33/68 ,  C07K1/14

CPC分类号： C07K16/36 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/745 ,  C07K16/18 ,  C07K2317/34 ,  Y10S530/83

摘要： The invention describes protein S polypeptides and anti-PS antibodies capable of inhibiting the binding of proteins to C4BP. The peptides and antibodies are useful in diagnostic methods and systems for purifying or detecting free protein S. in addition, the polypeptides are useful in therapeutic methods as an anti-coagulant.

公开(公告)号：EP0972781B1

公开(公告)日：2007-01-03

申请号：EP99202141.0

申请日：1992-07-02

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： Griffin, John H. ,  Fernandez, Jose A.

IPC分类号： C07K14/745 ,  C07K16/36 ,  A61K38/17 ,  A61K39/395 ,  G01N33/543 ,  G01N33/68 ,  C07K1/14

CPC分类号： C07K16/36 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/745 ,  C07K16/18 ,  C07K2317/34 ,  Y10S530/83

公开(公告)号：EP1591790A3

公开(公告)日：2006-07-19

申请号：EP04027083.7

申请日：1997-11-13

申请人： Thrombosis and Coagulation Aktiebolag (T.A.C. AB)

发明人： Dahlbäck, Björn

IPC分类号： G01N33/68 ,  G01N33/86 ,  C07K16/36 ,  C07K14/745

CPC分类号： G01N33/86 ,  C07K14/745 ,  C07K16/36 ,  G01N2333/7458

摘要： The present invention is concerned with an assay for free protein S comprising addition of a ligand specific for free protein S to a biological fluid sample to form a protein S/ligand complex, and subsequent determination of the amount of said complex formed in the sample. The ligand specific for free protein S is comprised of the C4b binding protein (C4BP) or part thereof or a compound comprising an amino acid residue sequence that binds specifically to the binding site for C4BP in protein S.

公开(公告)号：EP1334983B1

公开(公告)日：2006-04-12

申请号：EP03000857.7

申请日：2003-01-15

申请人： ZLB Behring GmbH

发明人： Römisch, Jürgen, Dr. ,  Lang, Wiegand ,  Feussner, Annette ,  Muth-Naumann, Gudrun ,  Stoehr, Hans-Arnold ,  Kannemaier, Christian ,  Preissner, Klaus ,  Nakazawa, Fumie

IPC分类号： C07K16/36 ,  C12N5/20 ,  C07K2/00 ,  C07K14/745 ,  A61K39/395 ,  G01N33/577 ,  A61P7/02

CPC分类号： C12N9/6424 ,  A61K47/6871 ,  A61K2039/505 ,  C07K16/40 ,  C12N9/6437 ,  C12Q1/37 ,  C12Y304/21021 ,  G01N33/86 ,  G01N2333/96447

公开(公告)号：EP1446157A4

公开(公告)日：2005-12-28

申请号：EP02793851

申请日：2002-10-29

申请人： SUNOL MOLECULAR CORP

发明人： JIAO JIAN-AN ,  WONG HING C ,  NIEVES ESPERANZA LILIANA ,  MOSQUERA LUIS A

IPC分类号： C07K16/28 ,  C07K16/36 ,  C07K16/46 ,  A61K39/395

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K16/467 ,  C07K2317/24 ,  C07K2319/00