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413 条记录 (耗时 0.038 秒)

    PROCESS FOR SYNTHESIS OF DERIVATIVES, COMPOUND LIBRARY, METHOD FOR MAKING THE MASE, AND SCREENING METHOD
    61.
    发明公开
    PROCESS FOR SYNTHESIS OF DERIVATIVES, COMPOUND LIBRARY, METHOD FOR MAKING THE MASE, AND SCREENING METHOD 审中-公开
    方法合成的衍生物连接库，用于生产体和筛选方法

    公开(公告)号：EP1795603A1

    公开(公告)日：2007-06-13

    申请号：EP05788164.1

    申请日：2005-09-27

    申请人： Keio University

    发明人： IMOTO, Masaya, c/o Keio University ,  OHTA, Hiromichi, c/o Keio University ,  MIYAMOTO, Kenji c/o Keio University

    IPC分类号： C12P17/16 ,  C12P17/18 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  A61K31/4523 ,  C07D405/06 ,  C07D493/04

    CPC分类号： C12P17/16 ,  C07D405/06 ,  G01N2500/00

    摘要： [Object] To provide a method for synthesizing derivatives of natural compounds; a method for constructing a compound library containing derivatives of natural compounds; a compound library containing derivatives of natural compounds; and a screening method using a compound library, which are useful for a HTS random screening, a search for drugs or agricultural chemicals, or a search for a lead compound of a drug or an agricultural chemical.
    [Solving Means] A derivative of an organic compound can be synthesized by culturing a microorganism producing the organic compound in a predetermined culture broth, and reacting the organic compound obtained by the culturing with a reaction reagent for synthesizing the derivative of the organic compound in the culturing broth. By constructing a library containing the thus obtained organic compound derivative, a HTS (high-throughput) random screening, a search for a drug or agricultural chemical, or a search for a lead compound of a drug or agricultural chemical can be performed.

    摘要翻译： 本发明的课题是提供一种用于合成天然化合物的衍生物的方法; 用于构建化合物文库含天然化合物的衍生物的方法; 化合物文库含天然化合物的衍生物; 并使用的化合物文库筛选方法，这是对HTS随机筛选，药物或农药进行搜索，或者或农业化学品的药物的先导化合物搜索有用的。 [解决手段]一种有机化合物的衍生物可以通过培养微生物在预定培养肉汤中生产有机化合物，和响应由所述培养用的反应试剂得到的有机化合物用于合成有机化合物的衍生物中的合成 培养肉汤。 通过构建含有由此得到的有机化合物衍生物，HTS（高通量）随机筛选一个库，可以执行用于将药物或农药，或用于药物或农用化学品的先导化合物的搜索的搜索。

    Electrochemical residual chlorine measuring method and device with a doped diamond working electrode
    62.
    发明公开
    Electrochemical residual chlorine measuring method and device with a doped diamond working electrode 审中-公开
    一种电化学方法和设备，用于测量残余的氯与掺杂金刚石工作电极

    公开(公告)号：EP1788382A1

    公开(公告)日：2007-05-23

    申请号：EP06024071.0

    申请日：2006-11-20

    申请人： HORIBA, LTD. ,  Keio University

    发明人： Nomura, Satoshi ,  Einaga, Yasuaki Keio University ,  Matsumoto, Koichi ,  Murata, Michio Keio University ,  Shibata, Mamoru Keio University

    IPC分类号： G01N27/30 ,  G01N27/49

    CPC分类号： G01N27/308 ,  G01N27/4045 ,  G01N33/0052

    摘要： A residual chlorine measuring method includes the steps of: bringing a counter electrode 4, a working electrode 2 and a reference electrode 3 into contact with a sample solution containing residual chlorine; applying a voltage between the counter electrode 4 and the working electrode 2; and measuring a current value when applying the voltage to calculate a concentration of the residual chlorine. The working electrode 2 is an electrically conductive diamond electrode to which boron is doped. The reference electrode 3 is a silver/silver chloride electrode. A current value when setting the potential of the electrically conductive diamond electrode 2 to the silver/silver chloride electrode 3 to +0.5 V to +1.5 V is measured.

    摘要翻译： 甲残留氯测定方法包括以下步骤：使对电极4，工作电极2和参比电极3与含有残氯的试样溶液接触; 施加对置电极4和工作电极2之间施加电压; 和测量的电流值。当将电压施加到计算的残留氯的浓度。 工作电极2是导电性金刚石电极有硼掺杂。 参比电极3是银/氯化银电极。 的电流值。当导电性金刚石电极2的电位设定为银/氯化银电极为3〜0.5 V至1.5 V的测定。

    Glow discharge drilling apparatus and glow discharge drilling method
    63.
    发明公开
    Glow discharge drilling apparatus and glow discharge drilling method 审中-公开
    Bohrvorrichtung und -verfahrenfürGlimmentladung

    公开(公告)号：EP1715504A2

    公开(公告)日：2006-10-25

    申请号：EP06008021.5

    申请日：2006-04-18

    申请人： HORIBA, LTD. ,  Keio University

    发明人： Hirano, Akihiro ,  Matsumoto, Koichi ,  Uchida, Yoshinobu ,  Mitani, Tomoaki ,  Shimizu, Kenichi

    IPC分类号： H01J37/31 ,  H01J37/301

    CPC分类号： H01J37/32082 ,  G01N1/08 ,  G01N1/32 ,  H01J37/301 ,  H01J37/31 ,  H01J37/32018 ,  H01J37/32366 ,  H01J2237/31745 ,  H01J2237/334

    摘要： A glow discharge drilling apparatus (1) enables switching of a continuous mode for continuously supplying electric power and an intermittent mode for intermittently supplying electric power. Electric power is supplied in the intermittent mode with respect to a sample (S) easily melted by a heat due to a glow discharge and a sample (S) easily broken by a force of sputtering due to a glow discharge or the like, whereby the sample (S) is drilled so that an observation face capable of carrying out good observation can be obtained. When the sample (S) is not easily melted and easily broken, the sample (S) is drilled so that a good observation face can be efficiently obtained by supplying electric power in the continuous mode.

    摘要翻译： 辉光放电钻孔装置（1）能够切换用于连续供电的连续模式和用于间歇地供电的间歇模式。 相对于由辉光放电引起的热容易熔化的样品（S）和由于辉光放电等容易被溅射的力破坏的样品（S）而以间歇模式供电， 钻取样品（S），从而可以获得能够进行良好观察的观察面。 当样品（S）不容易熔化并容易断裂时，钻取样品（S），从而通过以连续模式供给电力可以有效地获得良好的观察面。

    THREE-DIMENSIONAL SHAPE-MEASURING DEVICE
    65.
    发明公开
    THREE-DIMENSIONAL SHAPE-MEASURING DEVICE 有权
    EINRICHTUNG ZUR MESSUNG DREIDIMENSIONALER FORMEN

    公开(公告)号：EP1645841A1

    公开(公告)日：2006-04-12

    申请号：EP04745573.8

    申请日：2004-06-03

    申请人： SUMITOMO OSAKA CEMENT CO., LTD. ,  Keio University

    发明人： SATO, Isao Fac. Science and Technology, Keio Univ. ,  AOKI, H. Fac. Science and Technology, Keio Univ. ,  NAKAJIMA, M. Fac Science and Technology,Keio Univ. ,  MIMURA, K. Sumitomo Osaka Cement Co., Ltd. ,  TAKEMURA, Yasuhiro; Sumitomo Osaka Cement Co., Ltd ,  KATOU, Kei; Sumitomo Osaka Cement Co., Ltd. ,  TAKESUE, Toshiharu; Sumitomo Osaka Cement Co.,Ltd

    IPC分类号： G01B11/24

    CPC分类号： A61B5/1135 ,  A61B5/0064 ,  A61B5/1075 ,  A61B5/1127 ,  A61B5/1128 ,  A61B2562/0233 ,  G01B11/25

    摘要： A 3-D shape measurement apparatus for grasping the state of an object with ease and accuracy is provided. The 3-D shape measurement apparatus includes: a first 3-D sensor 10a having a projecting device 11 for projecting a light pattern on a target area, and a (first) image capturing apparatus 12a placed at a first interval d1 from the projecting device 11 to capture an image of the target area on which the light pattern is projected; a second 3-D sensor 10b having a projecting device 11, and a (second) image capturing apparatus 12b placed at a second interval d2 longer than the first interval d1 from the projecting device 11 to capture an image of the target area on which the light pattern is projected; 3-D information computing means 22 for obtaining external shape information on an object 2 based on the shift of the pattern on the image acquired with the first 3-D sensor 10a; variation information computing means 23 for obtaining variation information on the object 2 based on the shift of the pattern on the image acquired with the second 3-D sensor 10b; and information composing means 24 for composing the external shape information and the variation information.

    摘要翻译： 提供了一种容易且准确地掌握物体的状态的3-D形状测量装置。 3维形状测量装置包括：具有用于将目标区域上的光图案投影的投影装置11的第一3-D传感器10a和从投影装置以第一间隔d1放置的第一图像拍摄装置12a 11，以捕获其上投射有光图案的目标区域的图像; 具有投影装置11的第二3-D传感器10b和从投射装置11以比第一间隔d1更长的第二间隔d2放置的第二图像拍摄装置12b，以捕获目标区域的图像 预计光线图案; 3-D信息计算装置22，用于基于由第一3-D传感器10a获取的图像上的图案的移动来获得关于对象2的外部形状信息; 变化信息计算装置23，用于基于由第二3-D传感器10b获取的图像上的图案的移动来获得关于对象2的变化信息; 以及用于构成外部形状信息和变化信息的信息组合装置24。

    POLYPEPTIDE HUMANIN INHIBITING NERVE CELL DEATH
    70.
    发明公开
    POLYPEPTIDE HUMANIN INHIBITING NERVE CELL DEATH 有权
    POLYPEPTID，HUMANIN，WELCHES DAS ABSTERBEN VON NERVENZELLEN HEMMT

    公开(公告)号：EP1221480A1

    公开(公告)日：2002-07-10

    申请号：EP00961024.7

    申请日：2000-09-14

    申请人： Keio University

    发明人： Nishimoto, Ikuo Keio University School of Medicine

    IPC分类号： C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C07K14/47 ,  C07K7/08 ,  C07K16/18 ,  A61K48/00 ,  A61K38/10 ,  A61K38/17 ,  A61P25/28 ,  A61P25/00

    CPC分类号： C07K14/4711 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K2319/00

    摘要： The present invention provides polypeptides that suppresses neuronal death associated with Alzheimer's disease. Using a neuronal cell system, wherein the expression of familial Alzheimer's disease mutant APP can be induced by ecdysone treatment, a gene that protects the neurons from cell death was successfully isolated. The gene encodes a secretory polypeptide consisting of 24 amino acids, and this polypeptide suppresses neuronal death caused by the expression of APP mutants and presenilin mutants. The polypeptide also suppressed cell death of primary neuronal culture caused by Aβ. Furthermore, by mutating the amino acids of the polypeptide, the neuronal death suppression activity of the polypwptide was successfully and significantly enhanced. These polypeptides and derivatives thereof are useful as pharamaceuticals to prevent neuronal death associated with Alzheimer's disease, and as seed compounds for developing novel pharmaceuticals for Alzheimer's disease.

    摘要翻译： 本发明提供抑制与阿尔茨海默病有关的神经元死亡的多肽。 使用神经元细胞系统，其中家族性阿尔茨海默氏病突变体APP的表达可以通过蜕皮激素治疗诱导，成功分离了保护神经元免于细胞死亡的基因。 该基因编码由24个氨基酸组成的分泌多肽，并且该多肽抑制由APP突变体和早老素突变体的表达引起的神经元死亡。 多肽还抑制由Aβ引起的原代神经元培养的细胞死亡。 此外，通过突变多肽的氨基酸，成功并显着增强了聚磷酸的神经元死亡抑制活性。 这些多肽及其衍生物可用作药物以防止与阿尔茨海默病相关的神经元死亡，以及用于开发用于阿尔茨海默氏病的新型药物的种子化合物。