公开(公告)号：EP2229665B1

公开(公告)日：2012-03-07

申请号：EP08856967.8

申请日：2008-12-03

申请人： Vigilio ,  Universite Joseph Fourier - Grenoble 1

发明人： NOURY, Norbert ,  LUNDY, Jean-Eric

IPC分类号： G08B21/04 ,  A61B5/00 ,  G06F19/00

CPC分类号： A61B5/7282 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/02405 ,  A61B5/076 ,  A61B5/0816 ,  A61B5/1117 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/7246 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/7405 ,  A61B5/746 ,  G06F19/00 ,  G08B21/0446 ,  G08B21/0453 ,  G16H50/20

摘要： The invention relates to a method for detecting the critical situation of a subject that comprises measuring a physiological parameter of said subject. The method is characterised in that it comprises the following steps: (a) measuring the physiological parameter; (b) calculating a variation rate of the physiological parameter; (c) determining a synthesis variable for the physiological parameter by taking into account both the value of the parameter and the variation rate thereof; and (d) detecting a critical situation (25) from said synthesis variable. Advantageously, the steps (a) to (c) are implemented for at least two physiological parameters, and the method further includes determining a global decision variable (23) from the different synthesis variables, the critical situation being detected during step (d) from said global decision variable. The invention can be used for improving the detection of accidents or health problems particularly for the elderly at their places of residence.

公开(公告)号：EP2417151A1

公开(公告)日：2012-02-15

申请号：EP10723209.2

申请日：2010-04-06

申请人： Universite Joseph Fourier (Grenoble 1) ,  Centre National de la Recherche Scientifique ,  INSERM - Institut National de la Santé et de la Recherche Médicale

发明人： WONG, Yung-Sing ,  HAKIMI, Mohamed-Ali ,  BOUGDOUR, Alexandre ,  PELLOUX, Hervé ,  MAUBON, Danièle

IPC分类号： C07K5/12 ,  A61P33/02 ,  A61P33/06 ,  A61P33/00 ,  A61K38/12

CPC分类号： C07K5/126 ,  A61K38/00 ,  A61K38/07 ,  A61K38/12 ,  C07K1/107 ,  C07K1/1075 ,  C07K1/1077 ,  C07K5/12 ,  Y02A50/411

摘要： The present invention relates a method for preparing a cyclic peptide with an anti-parasitic activity and an anticancer activity. The invention also relates to said peptide as an anti-parasitic agent, for example, in treating toxoplasmosis, and as an anti-cancer agent. The invention also relates to the use of said cyclic peptide in the
ex vivo treatment of organs before transplantation.

公开(公告)号：EP2361422A1

公开(公告)日：2011-08-31

申请号：EP09755918.1

申请日：2009-11-23

申请人： UNIVERSITE JOSEPH FOURIER (GRENOBLE 1) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： OHAYON, Jacques ,  LE FLOC'H, Simon ,  FINET, Gérard ,  TRACQUI, Philippe

IPC分类号： G06T7/00

CPC分类号： G06T7/0012 ,  G06T7/44 ,  G06T2207/30101

摘要： The invention relates to an image processing method for estimating a risk of atheroma plaque breakage, that includes the step of receiving (40) a so-called elastogram image representing the inner deformation resulting from the compression of an analysed blood vessel tissue based on blood pressure, the step of pre-segmenting (50) the elastogram in order to obtain a pre-segmented image including a plurality of areas, and the step of calculating an elasticity image (60) representing the elasticity of at least one region of the elastogram, the region corresponding to an area selected among the plurality of areas of the pre-segmented image, and the elasticity image enabling the user to estimate the risk of atheroma plaque breakage, wherein said method is characterised in that: the pre-segmentation is carried out while considering the tissue as being a non-compressible elastic solid in order to determine the Young modulus gradient as equal to the sum of the Lagrange multiplier gradient and of a space depending vector, and in that the pre-segmentation includes determining the outlines of each area in the plurality of areas using said space depending vector.

摘要翻译： 本发明涉及一种用于估计动脉粥样硬化斑块破裂风险的图像处理方法，其包括以下步骤：接收（40）表示基于血压对分析的血管组织的压缩产生的内部变形的所谓弹性图像 ，为了获得包括多个区域的预分割图像，预先分割（50）弹性图形的步骤，以及计算表示弹性图形的至少一个区域的弹性的弹性图像（60）的步骤， 所述区域对应于在预分割图像的多个区域中选择的区域，以及弹性图像，其使得用户能够估计动脉粥样斑块破裂的风险，其中所述方法的特征在于：进行预分割 同时将组织视为不可压缩的弹性固体，以便确定杨氏模量梯度等于拉格朗日乘数梯度和o的和 f是空间依赖性矢量，并且所述预分割包括使用所述空间依赖矢量确定所述多个区域中的每个区域的轮廓。

公开(公告)号：EP2353145A1

公开(公告)日：2011-08-10

申请号：EP09783693.6

申请日：2009-10-02

申请人： Universite Joseph Fourier - Grenoble 1 ,  Centre National de la Recherche Scientifique (C.N.R.S)

发明人： BUCKI, Marek ,  PAYAN, Yohan

IPC分类号： G06T7/00

CPC分类号： G06T7/30 ,  A61B8/0808 ,  G06T2207/10072 ,  G06T2207/30016

摘要： The invention relates to a method for resetting a set of source points (S) in a reference image representing an organic tissue and a set of destination points (D) in a current image representing the deformed organic tissue. Said method involves the determination of a resetting function (R) by iterative minimisation of a resetting energy Ereg, the resetting function corresponding to a transformation enabling transfer from the source points of the reference image to the corresponding destination points (D) in the current image. The invention is characterised in that the resetting function (R) is an elastic resetting function satisfying the conditions that ensure that the physical criteria of the organic tissue are met, the conditions being: the Jacobian of the elastic resetting function is higher than 0, the resetting function is continuously differentiable, and the resetting function is bijective.

摘要翻译： 本公开涉及一种用于估计患者脑移位的图像处理方法，所述方法涉及：在外科手术之前获取的患者的脑的三维图像的处理，以获得参考大脑动脉 患者的树状结构; 处理在手术期间获取的患者脑部的三维图像，以便至少部分地重建患者的当前大脑动脉树结构; 来自参考和当前脑动脉树结构的组合的确定，表示当前血管树相对于参考血管树的移动的血管树的移动场; 将确定的血管树的移位领域应用于患者脑的生物力学模型，以估计患者的脑移位; 以及来自估计的脑移位的至少一个患者脑的图像的产生，其中脑移位被补偿。

公开(公告)号：EP2190884B1

公开(公告)日：2011-07-20

申请号：EP08804024.1

申请日：2008-09-11

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Universite Joseph Fourier - Grenoble 1

发明人： AUZELY-VELTY, Rachel ,  CREUZET, Caroline

IPC分类号： C08B37/00 ,  C08G65/333 ,  C08G81/00 ,  A61K8/73 ,  A61K8/91 ,  A61K31/722 ,  A61P17/02 ,  A61L27/20 ,  A61L27/52

CPC分类号： A61L27/52 ,  A61K8/042 ,  A61K8/90 ,  A61K31/722 ,  A61L27/20 ,  A61Q19/00 ,  C08B37/003 ,  C08G65/331 ,  C08G65/3324 ,  C08G65/333 ,  C08G81/00 ,  C08G2261/126 ,  C08G2650/50 ,  C08J3/075 ,  C08J2387/00 ,  C08L5/08 ,  C08L71/02 ,  C08L3/00

摘要： The invention relates to a thermosensitive (poly(ethylene oxide) poly(propylene oxide))-acetal derivative, which can be used to functionalize chitosan, and to the process for the preparation thereof. The invention therefore also relates to a process for functionalizing chitosan by grafting this thermosensitive copolymer and optionally another thermosensitive polymer, poly(ethylene oxide). A subject of the invention is also a chitosan-(poly(ethylene oxide) poly(propylene oxide))-poly(ethylene oxide) derivative which has the advantage of being water-soluble at physiological pH. The invention therefore also relates to the aqueous compositions comprising this derivative and to the use of this composition for the manufacture of gel by heating.

公开(公告)号：EP2247530A2

公开(公告)日：2010-11-10

申请号：EP09706787.0

申请日：2009-01-28

申请人： Universite Joseph Fourier - Grenoble 1 ,  Centre National de la Recherche Scientifique (C.N.R.S)

发明人： COSNIER, Serge ,  HOLZINGER, Michael ,  IONESCU, Elena, Rodica

IPC分类号： C01B31/02

CPC分类号： C09D4/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C01B2202/02 ,  C01B2202/34 ,  C01B2202/36 ,  C08K3/04 ,  C09D7/45 ,  C09D7/70 ,  C25D13/04 ,  C25D15/00 ,  Y10T428/2998

摘要： The invention concerns an aqueous composition comprising carbon nanotubes and a surfactant, characterized in that the carbon nanotubes are single-wall hydrophobic nanotubes and in that the surfactant is chosen among electropolymerizable surfactant monomers of formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ X-Y-Z€ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein: X is an electropolymerizable moiety selected from the group consisting of pyrrole, acetylene, phenol, aniline, thiophene, carbazole, indole and azulene Y is a hydrophobic hydrocarbon chain and Z is a polar group selected from the group consisting of quaternary ammonium salts, alkylphosphonates and sulfonates. The invention also relates to a method for the preparation of an aqueous composition as described above, comprising the following steps: i) solubilisation of the surfactant monomer ii) addition of the single-wall carbon nanotubes in the aqueous solution comprising said surfactant monomer, (iii) sonication of the resulting solution, and, optionally (iv) addition of a protein.

公开(公告)号：EP2190884A1

公开(公告)日：2010-06-02

申请号：EP08804024.1

申请日：2008-09-11

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Universite Joseph Fourier - Grenoble 1

发明人： AUZELY-VELTY, Rachel ,  CREUZET, Caroline

IPC分类号： C08B37/00 ,  C08G65/333 ,  C08G81/00 ,  A61K8/73 ,  A61K8/91 ,  A61K31/722 ,  A61P17/02 ,  A61L27/20 ,  A61L27/52

CPC分类号： A61L27/52 ,  A61K8/042 ,  A61K8/90 ,  A61K31/722 ,  A61L27/20 ,  A61Q19/00 ,  C08B37/003 ,  C08G65/331 ,  C08G65/3324 ,  C08G65/333 ,  C08G81/00 ,  C08G2261/126 ,  C08G2650/50 ,  C08J3/075 ,  C08J2387/00 ,  C08L5/08 ,  C08L71/02 ,  C08L3/00

摘要： The invention relates to a thermosensitive (poly(ethylene oxide) poly(propylene oxide))-acetal derivative, which can be used to functionalize chitosan, and to the process for the preparation thereof. The invention therefore also relates to a process for functionalizing chitosan by grafting this thermosensitive copolymer and optionally another thermosensitive polymer, poly(ethylene oxide). A subject of the invention is also a chitosan-(poly(ethylene oxide) poly(propylene oxide))-poly(ethylene oxide) derivative which has the advantage of being water-soluble at physiological pH. The invention therefore also relates to the aqueous compositions comprising this derivative and to the use of this composition for the manufacture of gel by heating.

公开(公告)号：EP2190340A1

公开(公告)日：2010-06-02

申请号：EP08787336.0

申请日：2008-08-20

申请人： Universite Joseph Fourier - Grenoble 1

发明人： CINQUIN, Philippe ,  VOROS, Sandrine ,  BOSCHET, Christophe ,  FOUARD, Céline ,  MOREAU-GAUDRY, Alexandre

IPC分类号： A61B1/00

CPC分类号： A61B1/042 ,  A61B1/00193

摘要： The invention relates to an endoscopic imaging system for observing an operation field (2) in a space (1) located inside the body of an animal, that comprises: an image acquisition means (3) for providing information on the operation field (2); a means (4) for processing the information from the acquisition means; a display means (5) for the information processed by the processing means (4), characterised in that: the acquisition means (3) includes at least two independent image acquisition devices mobile relative to each other, the image acquisition devices being adapted to be positioned in the space (1); and in that the processing means (4) includes computing means for obtaining three-dimensional information on the observed operation field (2) from the information received from the image acquisition devices, and a means for reconstructing a three-dimensional image of a region of interest in the operation field from the obtained three-dimensional information.

公开(公告)号：EP2185102A1

公开(公告)日：2010-05-19

申请号：EP08787000.2

申请日：2008-08-07

申请人： Universite Joseph Fourier - Grenoble 1

发明人： CINQUIN, Philippe ,  MOZER, Pierre ,  LAMRAOUI, Hamid ,  BONVILAIN, Agnès ,  ROBAIN, Gilberte

IPC分类号： A61F2/00 ,  A61F2/02

CPC分类号： A61F2/0036 ,  A61B5/04882 ,  A61B5/1116 ,  A61B5/202 ,  A61B5/205 ,  A61B2562/0219 ,  A61F2250/0002

摘要： The invention relates to a device for preventing urinary leakage to be implanted in a patient, that comprises: compression means (1, 3, 4, 5) for the patient's urethra; an electronic control means (2) for actuating the compression means (1, 3, 4, 5); characterised in that it further comprises a means (7) for measuring the patient's activity and coupled to the control means (2), wherein the control means (2) operates according to a predictive model of the urinary leakages based on the patient's activity in order to anticipate a potential urinary leakage based on the patient's measured activity.

摘要翻译： 本发明涉及一种用于防止意图植入患者的尿漏的装置，包括：压缩装置（1,3,4,5）以压缩患者的尿道，电子控制装置（2）致动压缩装置（1， 3，4，5），其特征在于，还包括用于测量患者活动的测量装置（7），与控制装置（2）耦合，控制装置（2）根据基于 患者活动，以便预期与测量的患者活动相关的可能的尿液泄漏。

公开(公告)号：EP1383732B1

公开(公告)日：2010-02-17

申请号：EP02740788.1

申请日：2002-05-03

申请人： BIO MERIEUX ,  UNIVERSITE JOSEPH FOURIER (GRENOBLE 1) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： BOURGET, Cécile ,  LHOMME, Jean ,  LAAYOUN, Ali ,  KOTERA, Mitsuharu ,  TREVISIOL, Emmanuelle ,  MENOU, Lionel ,  BERNAL MENDEZ, Eloy

IPC分类号： C07C245/14 ,  C07C245/18 ,  C07D209/14 ,  C07D495/04 ,  C07D311/82 ,  C12Q1/68

CPC分类号： C07D209/08 ,  C07C245/14 ,  C07C245/18 ,  C07D311/90 ,  C07D495/04