公开(公告)号：EP0593065B1

公开(公告)日：2002-08-21

申请号：EP93116673.0

申请日：1986-09-11

申请人： Scios Inc.

发明人： Abraham, Judith A. ,  Fiddes, John C.

IPC分类号： C12N15/16 ,  C12N1/21 ,  C12N5/10 ,  C12N15/86

CPC分类号： C07K14/503 ,  A61K38/00 ,  C07K14/501 ,  C12N15/67

公开(公告)号：EP0502589B1

公开(公告)日：2001-09-26

申请号：EP92201245.5

申请日：1986-03-27

申请人： F. HOFFMANN-LA ROCHE AG

发明人： Mullis, Kary Banks ,  Arnheim, Norman ,  Saiki, Randall Keichi ,  Erlich, Henry Anthony ,  Horn, Glenn Thomas ,  Scharf, Stephen Joel

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12N15/10 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00722 ,  B01L7/52 ,  C07K14/805 ,  C12Q1/6853 ,  C12Q1/6858 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q1/689 ,  C40B40/06 ,  C40B60/14 ,  C12Q2525/131 ,  C12Q2521/513

公开(公告)号：EP1063286A1

公开(公告)日：2000-12-27

申请号：EP99901955.7

申请日：1999-02-08

申请人： Toyo Kohan Co., Ltd

发明人： TANGA, Michifumi, Toyo Kohan Co., Ltd. ,  TAKAHASHI, Kojiro

IPC分类号： C12M1/00 ,  C12Q1/68 ,  C12N15/00

CPC分类号： C12Q1/6844 ,  B01J2219/00274 ,  B01J2219/00306 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00515 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00722 ,  C12Q1/6834 ,  C12Q1/686 ,  C12Q2565/518 ,  C40B40/06 ,  C40B60/14 ,  C12Q2531/113 ,  C12Q2527/00 ,  C12Q2565/537 ,  C12Q2521/107

摘要： A purpose of the present invention is to provide substrates utilized for a library of DNA by immobilizing DNA and DNA-immobilized chips utilized for reproducing DNA by a PCR amplifying reaction. In the present invention, PCR amplifying method is operated by utilizing DNA-immobilized chips having DNA immobilized on an excellent conductive substrate. A surface of the substrate is chemically modified with a radical of which a terminal is a polar radical. In the PCR method, DNA can be amplified for a short period by utilizing DNA-immobilizing chips having DNA immobilized on the substrates.

摘要翻译： 本发明的目的是提供一种基片通过固定用于通过PCR扩增反应的DNA再现DNA和DNA-固定化芯片用于DNA的文库。 在本发明中，PCR放大方法是通过在一个极好的导电性基板利用具有DNA固定的DNA固定化芯片进行操作。 衬底的表面被化学与自由基的终端是极性基团的改性。 在PCR方法中，DNA可用于扩增通过利用具有固定化在基片上的DNA的DNA芯片固定在短时间内。

公开(公告)号：EP1055429A1

公开(公告)日：2000-11-29

申请号：EP99902905.1

申请日：1999-02-15

申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute ,  KOWA COMPANY LTD.

发明人： SASAKI, Takumi ,  KIMACHI, Kazuhiko ,  SOEJIMA, Kenji ,  KIMURA, Yumi ,  NOZAKI, Chikateru ,  FUJIYAMA, Yoshihide

IPC分类号： A61K39/09 ,  A61K38/16

CPC分类号： C07K14/31 ,  A61K38/164 ,  A61K39/085

摘要： A prophylactic/remedy for immunopathy for immunopathy comprising, as an active ingredient, modifications of Staphylococcal enterotoxin B (SEB) with substitution of at least one amino acid residues within the amino acid sequence of natural type SEB, or derivatives thereof, wherein said SEB modifications or derivatives thereof have inhibitory activity on T cell activation wherein they interact with specific Vβ component of T cell receptor (TCR) but are reduced in their immunological responsiveness to SEB without inducing elimination of T cells having specific Vβ component, the elimination being normally induced by natural type SEB or recombinant wild-type SEB.

摘要翻译： 作为免疫疾病免疫病的预防/治疗方法，其包含用天然型SEB的氨基酸序列中的至少一个氨基酸残基取代的葡萄球菌肠毒素B（SEB）或其衍生物作为活性成分的修饰，其中所述SEB修饰 或其衍生物对T细胞活化具有抑制活性，其中它们与T细胞受体（TCR）的特异性Vβ组分相互作用，但其对SEB的免疫应答降低，而不诱导具有特异性Vβ组分的T细胞的消除，消除正常 由天然型SEB或重组野生型SEB诱导。

公开(公告)号：EP0592562B1

公开(公告)日：1999-01-07

申请号：EP92914973.0

申请日：1992-06-25

申请人： GENETICS INSTITUTE, INC.

发明人： WOZNEY, John, M. ,  CELESTE, Anthony, J.

IPC分类号： C12N15/12 ,  C12P21/02

CPC分类号： C07K14/51 ,  A61K38/00 ,  C07K2319/02

摘要： Purified BMP-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.

公开(公告)号：EP0407392B2

公开(公告)日：1998-10-28

申请号：EP89901649.7

申请日：1988-12-29

申请人： TANOX BIOSYSTEMS, INC.

发明人： CHANG, Tse-Wen ,  SUN, Bill, Nai-Chau ,  SUN, Cecily, Rou-Yun

IPC分类号： A61K39/395 ,  C12P21/00 ,  A61K47/00 ,  C12N5/00 ,  C12N15/00

CPC分类号： A61K45/06 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K47/643 ,  A61K47/6873 ,  C07K16/00 ,  C07K16/4241 ,  C07K16/4291 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/33 ,  A61K2300/00

公开(公告)号：EP0833846A1

公开(公告)日：1998-04-08

申请号：EP95925238.0

申请日：1995-06-05

申请人： HUMAN GENOME SCIENCES, INC.

发明人： SOPPET, Daniel, R. ,  LI, Yi ,  ROSEN, Craig, A. ,  RUBEN, Steven, M.

IPC分类号： C07K14 ,  A61K38

CPC分类号： C07K14/705 ,  A61K38/00 ,  C12N2799/026

摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

公开(公告)号：EP0831903A1

公开(公告)日：1998-04-01

申请号：EP96916841.0

申请日：1996-05-31

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： GROTENDORST, Gary, R. ,  BRADHAM, Douglass, M., Jr.

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K48 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P17 ,  A61P27 ,  A61P35 ,  A61P43 ,  C07K14 ,  C12N5 ,  C12Q1 ,  G01N33

CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K38/1841 ,  A61K38/39 ,  C12N5/0655 ,  A61K2300/00

摘要： The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides CTGF, and including 5'and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-β responsive element upstream of the polynucleotide encoding CTGF structural gene.

公开(公告)号：EP0452457B1

公开(公告)日：1997-08-20

申请号：EP90916560.7

申请日：1990-10-18

申请人： VANDERBILT UNIVERSITY

发明人： BRIGHAM, Kenneth, L.

IPC分类号： A61K48/00 ,  A61K9/127 ,  C12N15/88

CPC分类号： A61K48/00 ,  A61K9/1272

摘要： A method of expressing a foreign gene in cells of a mammalian organ in vivo includes the step of injecting genetic material capable of inducing desired gene products into a mammal. The genetic material is complexed to cationic liposome carriers. The genetic material is lipofected into cells of the mammalian organ. Gene expression and cellular function of the genetic material are activated to produce the desired foreign products in the cells of the organ.

公开(公告)号：EP0784679A1

公开(公告)日：1997-07-23

申请号：EP95933885.0

申请日：1995-09-21

申请人： THE WORCESTER FOUNDATION FOR BIOMEDICAL RESEARCH

发明人： ROSS, Alonzo, H. ,  POLUHA, Wojciech ,  LACHYANKAR, Mahesh, B. ,  POLUHA, Dorota, K.

IPC分类号： A61K38 ,  A61K31 ,  A61K48 ,  A61P35 ,  C07K14 ,  C12N15 ,  C12Q1

CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

摘要： Disclosed is a method of reducing or inhibiting the tumorigenicity of a tumor cell in which a vector including a nucleotide sequence encoding a differentiation factor receptor, or a polypeptide portion thereof, is transferred to the tumor cell such that the nucleotide sequence is expressed. Tumorigenicity is monitored by cell growth and colony formation in a semi-soft medium, a reduction in proliferation being indicative of the reduction or inhibition of tumorigenicity of the treated tumor cell.