公开(公告)号：EP4276099A1

公开(公告)日：2023-11-15

申请号：EP22736595.4

申请日：2022-01-07

申请人： Phaeno Therapeutics Co., Ltd. ,  Medshine Discovery Inc.

发明人： CHEN, Kevin X ,  XIONG, Jian ,  WANG, Jingjing ,  HU, Guoping ,  LIU, Jinxin ,  HAN, Yu ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D421/14 ,  C07D471/14 ,  C07D519/00 ,  C07D513/14 ,  C07D498/14 ,  C07F11/00 ,  A61K31/503 ,  A61K31/53 ,  A61P31/16

摘要： Provided are a class of pyridone multiple-membered ring derivatives and the use thereof. Specifically provided are a compound as represented by formula (VI) and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4206201A1

公开(公告)日：2023-07-05

申请号：EP21865949.8

申请日：2021-09-06

申请人： Medshine Discovery Inc.

发明人： XU, Zhaobing ,  ZHOU, Ming ,  YAO, Ting ,  HU, Lihong ,  DING, Charles Z. ,  CHEN, Shuhui

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P35/00

摘要： A crystal form of an azetidine-substituted compound as represented by formula (I) and a preparation method therefor. Further comprised is an application of the crystal form in preparing a drug for treating cancer.

公开(公告)号：EP4174059A1

公开(公告)日：2023-05-03

申请号：EP21833499.3

申请日：2021-06-28

申请人： Medshine Discovery Inc.

发明人： AN, Ke ,  GAO, Na ,  HU, Guoping ,  LI, Jian ,  CHEN, Shuhui ,  SUN, Deheng

IPC分类号： C07D403/12 ,  C07D401/12 ,  A61K31/395 ,  A61P35/00

摘要： A novel indazole compound, a preparation method therefor, and use thereof in the preparation of drugs for treating related diseases. Specifically disclosed are a compound of formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4166541A1

公开(公告)日：2023-04-19

申请号：EP21820982.3

申请日：2021-06-07

申请人： Medshine Discovery Inc.

发明人： QIAN, Wenyuan ,  LIAO, Yonggang ,  WEI, Changqing ,  XI, Zhengying ,  XIAO, Yao ,  CHEN, Shuhui

IPC分类号： C07D213/71 ,  C07D307/64 ,  C07D231/18 ,  C07D333/34 ,  C07D263/46 ,  C07D277/36 ,  A61K31/175

摘要： Disclosed in the present invention is a series of dimethylsulfoximine derivatives, and specifically disclosed are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4159730A1

公开(公告)日：2023-04-05

申请号：EP21808699.9

申请日：2021-05-19

申请人： Medshine Discovery Inc.

发明人： LUO, Yunfu ,  BA, Yuyong ,  CHEN, Shuhui

IPC分类号： C07D403/12 ,  A61K31/4196 ,  A61K31/4178 ,  A61P1/16

摘要： Disclosed are a series of compounds having pyridine structures or pharmaceutically acceptable salts thereof, and an application thereof in the preparation of drugs for the treatment of related diseases. Specifically, disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4089095A1

公开(公告)日：2022-11-16

申请号：EP21738457.7

申请日：2021-01-07

申请人： Medshine Discovery Inc.

发明人： FU, Zhifei ,  LUO, Miaorong ,  ZHANG, Yang ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D495/04 ,  A61K31/4365 ,  A61K31/444 ,  A61P35/00

摘要： Disclosed is a deuterated thienopyridine compound. Specifically disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4071152A1

公开(公告)日：2022-10-12

申请号：EP20896043.5

申请日：2020-12-07

申请人： Medshine Discovery Inc.

发明人： LI, Yi ,  LIU, Ning ,  YU, Tao ,  WU, Chengde ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D495/04 ,  A61K31/429 ,  A61K31/4015 ,  A61P35/00

摘要： A spiro compound serving as an ERK inhibitor, and an application thereof in preparing a drug for treating an ERK-related disease. The present invention specifically relates to a compound represented by formula (III) or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4067359A1

公开(公告)日：2022-10-05

申请号：EP20892868.9

申请日：2020-11-25

申请人： Medshine Discovery Inc.

发明人： CHEN, Kevin X ,  XIA, Shanghua ,  CHEN, Zhaoguo ,  GUO, Zuhao ,  YU, Yanxin ,  ZHOU, Kai ,  HU, Boyu ,  ZHANG, Li ,  JIANG, Fen ,  WANG, Jingjing ,  HU, Guoping ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D473/18 ,  C07D519/00 ,  A61K31/522 ,  A61P35/00

摘要： A class of DNA-PK inhibitors, in particular a compound represented by formula (IV) or a pharmaceutically acceptable salt thereof, and an application thereof in the preparation of a drug relating to a DNA-PK inhibitor.

公开(公告)号：EP4059935A1

公开(公告)日：2022-09-21

申请号：EP20887944.5

申请日：2020-11-13

申请人： Medshine Discovery Inc.

发明人： ZHANG, Yang ,  WU, Wentao ,  GENG, Kaijun ,  LI, Qiu ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P29/00 ,  A61P37/02 ,  A61P35/02

摘要： Disclosed are a pyrrolopyrimidine compound and a use thereof in preparing a medicine for diseases related to a BTK protein kinase inhibitor. Specially, disclosed are a compound as shown in formula (III) and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4046686A1

公开(公告)日：2022-08-24

申请号：EP20876972.9

申请日：2020-10-16

申请人： Medshine Discovery Inc.

发明人： WU, Lingyun ,  XIAO, Zheming ,  JIANG, Chunyan ,  LI, Jian ,  CHEN, Shuhui

IPC分类号： A61P11/00 ,  C07D401/04 ,  A61K31/4439

摘要： Salt types, crystal forms, and preparation methods for benzopyrazole compounds as RHO kinase inhibitors. Specifically, disclosed are hydrochloride and acetate of compounds of formula (I) and crystal forms thereof, as well as application of the salt types and the crystal forms in preparation of RHO inhibitor drugs.