利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

86 条记录 (耗时 0.025 秒)

    PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY
    61.
    发明公开
    PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY 有权
    与细胞死亡抑制活性肽片段

    公开(公告)号：EP1132402A4

    公开(公告)日：2005-12-21

    申请号：EP99972642

    申请日：1999-11-12

    申请人： CHEMO SERO THERAPEUT RES INST

    发明人： HIRASHIMA MASAKI ,  MAEDA HIROAKI ,  NOZAKI CHIKATERU

    IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K38/17 ,  C07K16/18 ,  C12N5/06

    CPC分类号： C07K14/4747 ,  A61K38/00

    摘要： Peptide fragment(s) having an activity of inhibiting cell death which contain the amino acid sequence consisting of 103 amino acid residues in the C-terminal side of selenoprotein P, an amino acid sequence derived from the above amino acid sequence by deletion, substitution or addition of one or several amino acids therein, or a partial sequence of either of the above amino acid sequences; remedies containing the above peptide fragment(s); antibodies against the above peptide fragment(s); and a method for screening a cell death inhibitory activity with the use of the above peptide fragment(s). Preferable examples of the above peptide fragment(s) are those containing the amino acid sequence(s) represented by SEQ ID NO:1 and/or 2 or partial sequences thereof.

    Oil adjuvant vaccine and method for preparing same
    62.
    发明公开
    Oil adjuvant vaccine and method for preparing same 失效
    ÖladjuvierterImpfstoff und Verfahren zu seiner Herstellung

    公开(公告)号：EP0781559A3

    公开(公告)日：1998-12-16

    申请号：EP96308676

    申请日：1996-11-29

    申请人： CHEMO SERO THERAPEUT RES INST ,  NOF CORP

    发明人： MIYAHARA TOKUJI ,  TAKASE KOZO ,  SAITO KOICHI ,  KISHIMOTO YOKO ,  TOKUYAMA SATORU

    IPC分类号： A61K39/39 ,  A61K9/113

    CPC分类号： A61K39/39 ,  A61K2039/55566 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/943

    摘要： A water-in-oil type oil adjuvant vaccine comprises 20 to 90% by weight of an oil phase A) which is in a liquid state at ordinary temperature; 0.5 to 30% by weight of an emulsifying agent comprising a non-ionic surfactant B) which is a partial ester derived from a polyhydric alcohol carrying at least three hydroxyl groups and a fatty acid and which is in a liquid state at 40°C and a polyoxyethylene (20 to 60 moles) hydroxy fatty acid triglyceride C); and 5 to 75% by weight of an aqueous phase D) containing a biologically acceptable and effective amount of antigens, and optionally E) 0.01 to 10% by weight of an amino acid or a salt thereof and 0.01 to 10% by weight of a non-reducing sugar or a sugar alcohol having at least 5 hydroxyl groups in the molecule. In addition, a water-in-oil-in-water type oil adjuvant vaccine comprises the foregoing water-in-oil type oil adjuvant vaccine as an internal phase and an outer aqueous phase F) comprising 0.2 to 20% by weight of an emulsifying agent which comprises a non-ionic surfactant and which has an overall HLB value of not less than 10. The oil adjuvant vaccines show a high ability to induce an antibody-production over a long period of time and are excellent in requirements for medicines such as stability and safety.

    摘要翻译： 油包油型油佐剂疫苗含有20〜90重量％的油相A），其在常温下为液态; 0.5至30重量％的包含非离子表面活性剂B）的乳化剂，其为衍生自至少三个羟基和脂肪酸的多元醇的偏酯，并且在40℃处于液态， 聚氧乙烯（20至60摩尔）羟基脂肪酸甘油三酯C）; 和5至75重量％的含有生物可接受和有效量的抗原的水相D），以及任选的E）0.01至10重量％的氨基酸或其盐和0.01至10重量％的 非还原糖或分子中具有至少5个羟基的糖醇。 此外，水包油包水型油佐剂疫苗包含上述油包水型油佐剂疫苗作为内相，外部水相F）包含0.2-20重量％的乳化剂 其包含非离子表面活性剂，其总体HLB值不小于10.油佐剂疫苗显示出在长时间内诱导抗体产生的高能力，并且对药物的需求优异，例如 稳定和安全。

    ARTIFICIAL BLOOD VESSEL USING DECELLULARIZED BLOOD VESSEL SHEET
    65.
    发明公开
    ARTIFICIAL BLOOD VESSEL USING DECELLULARIZED BLOOD VESSEL SHEET 审中-公开
    KÜNSTLICHESBLUTGEFÄSSUNTER VERWENDUNG EINER DEZELLULARISIERTENBLUTGEFÄSSFOLIE

    公开(公告)号：EP2944330A4

    公开(公告)日：2016-09-07

    申请号：EP13871129

    申请日：2013-12-17

    申请人： CHEMO SERO THERAPEUT RES INST

    发明人： SHINYA NORIKO ,  UCHIDA TAKANORI ,  KISHIDA AKIO ,  HIGAMI TETSUYA

    IPC分类号： A61L27/36 ,  A61F2/06

    CPC分类号： A61F2/82 ,  A61F2/06 ,  A61F2/062 ,  A61F2230/0069 ,  A61F2240/002 ,  A61L27/3625 ,  A61L27/3683 ,  A61L27/507 ,  A61L27/54 ,  A61L2300/252 ,  Y10T156/1038 ,  A61L27/34 ,  C08L89/00

    摘要： An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.

    摘要翻译： 可以移植到具有小直径的血管的人造血管可以调节到任意尺寸的直径，提高移植物时的侵入性，并且克服了提供移植物的问题。 由脱细胞化的管状结构制备的人造血管，其通过将脱细胞化的片状血管（脱细胞血管片）加工成辊结构而制备，以及组织粘合剂，其中与血液接触的部分 在人造血管内部由内膜内膜与中膜的组织组成，而当片材加工成辊结构（重叠宽度）时与片材重叠的部分片材由中膜的组织组成 并且其中将组织粘合剂施加到所述重叠宽度。