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公开(公告)号：EP0723957B1
公开(公告)日：2003-05-21
申请号：EP95309452.1
申请日：1995-12-27
发明人： Omura, Satoshi, c/o The Kitasato Institute , Sunazuka, Toshiaki, c/o The Kitasato Institute , Tanaka, Haruo, c/o The Kitasato Institute
IPC分类号： C07D207/28 , A61K31/40 , C07D401/12
CPC分类号： C07D401/12 , C07D207/28
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62.发明公开
公开(公告)号：EP1270728A1
公开(公告)日：2003-01-02
申请号：EP01906278.5
申请日：2001-02-23
发明人： ENDO, Hirofumi, Kyowa Hakko Kogyo Co. Ltd. , YAMAGUCHI, Hiroyuki, Tokyo Res. Lab. Kyowa Hakko , KANDA, Yutaka, Pharm. Res. Inst. Kyowa Hakko , HASHIMOTO, Shinichi, Tokyo Res. Lab. Kyowa Hakko , OMURA, Satoshi , IKEDA, Haruo
CPC分类号： C12N15/52 , C07C327/30
摘要： According to the present invention, 22,23-dihydroavermectin B1a, which is useful as a medicine, a veterinary drug, and a pesticide, can be directly fermented and produced. This can obviate the need for the complicated and difficult conventional processes for purifying avermectin B1a at an industrial level and for chemically modifying avermectin B1a and can significantly decrease cost and time required in the industrial production of 22,34-dihydroavermectin B1a. The production of the formulation containing only 22,23-dihydroavermectin B1a, which is highly effective as a medicine, is also realized.
摘要翻译： 根据本发明，可以直接发酵和制造可用作药物，兽药和农药的22,23-二氢阿凡曼菌素B1a。 这可以避免需要复杂且困难的用于纯化工业水平的除虫菌素B1a和用于化学改性除虫菌素B1a的常规方法，并且可以显着降低工业生产22,34-二氢阿凡曼菌素B1a所需的成本和时间。 也可以实现仅含有作为药物高度有效的22,23-二氢阿凡曼明B1a的制剂的生产。
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公开(公告)号：EP0723957A1
公开(公告)日：1996-07-31
申请号：EP95309452.1
申请日：1995-12-27
发明人： Omura, Satoshi, c/o The Kitasato Institute , Sunazuka, Toshiaki, c/o The Kitasato Institute , Tanaka, Haruo, c/o The Kitasato Institute
IPC分类号： C07D207/28 , A61K31/40 , C07D401/12
CPC分类号： C07D401/12 , C07D207/28
摘要： A compound which is a lactacystin derivative of formula (I):
wherein:
R is C 1 -C 4 alkoxy, -S-(CH 2 ) n R 1 or -S-(CH 2 ) n -CH(R 2 )(R 3 ), in which:
R 1 is branched or unbranched C 1 -C 4 alkyl, hydroxy, carboxyl, (C 1 -C 4 alkoxy)carbonyl, unsubstituted or substituted phenyl, unsubstituted or substituted amino or pyridyl,
R 2 is unsubstituted or substituted amino, C 1 -C 4 alkyl or an amino acid residue, and
R 3 is carboxyl, (C 1 -C 4 alkoxy)carbonyl, (C 2 -C 4 alkenyloxy)carbonyl or an amino acid residue, and
n is 0 to 4,
with the proviso that lactacystin is excluded,
or a pharmacologically acceptable salt thereof.摘要翻译： 作为式（I）的乳胞素衍生物的化合物：其中：R为C 1 -C 4烷氧基，-S-（CH 2）n R 1或-S-（CH 2）n -CH（R 2） ）（R 3），其中：R 1是支链或非支链C 1 -C 4烷基，羟基，羧基，（C 1 -C 4烷氧基）羰基，未取代或取代的苯基，未取代或取代的氨基或吡啶基， 2'是未取代或取代的氨基，C 1 -C 4烷基或氨基酸残基，R 3是羧基，（C 1 -C 4烷氧基）羰基，（C 2 -C 4烯氧基）羰基或氨基酸残基，n是 0至4，条件是排除乳胞素或其药理学上可接受的盐。
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64.发明公开
公开(公告)号：EP0540135A3
公开(公告)日：1993-12-08
申请号：EP92302004.4
申请日：1992-03-10
发明人： Sasaki, Keiko, c/o The Kitasato Institute , Mori, Takayuki, c/o The Kitasato Institute , Makino, Satoshi, c/o The Kitasato Institute
IPC分类号： C12N15/45 , C12N7/00 , A61K39/165 , C12Q1/68 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2760/18421 , C12N2760/18422
摘要： A measles vaccine virus AIK-C strain containing specific nucleotide sequence comprising the viral genomic RNA in the seed virus for measles vaccine or measles virus vaccine consisting of 15,894 nucleotides is provided.
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公开(公告)号：EP0295043A3
公开(公告)日：1989-07-26
申请号：EP88305166.6
申请日：1988-06-07
IPC分类号： A61K39/12
CPC分类号： A61K39/165 , A61K39/12 , A61K39/20 , A61K2039/5254 , C12N2760/18434 , C12N2760/18734 , C12N2770/36234
摘要： A vaccine, which comprises at least one live attenuated plain virus selected from measles, mumps or rubella virus and, as a stabilizing agent, 2.5 to 5 W/V% lactose, 2.5 to 5 W/V% saccharose, 1.8 to 2 W/V% D-sorbitol, about 0.1 W/V% sodium glutamate and 2 to 3 W/V% gelatin hydrolysate having a molecular weight of about 35,000.
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66.发明公开
公开(公告)号：EP0189330A2
公开(公告)日：1986-07-30
申请号：EP86300498.2
申请日：1986-01-24
发明人： Komiyama, Kanki , Funayama, Shinji , Umezawa, Iwao
IPC分类号： C07D225/06 , C12P17/10 , A61K31/395
CPC分类号： C12R1/465 , C07D225/06 , C12P17/10
摘要： Trienomycins of the formula (I)
wherein R is hexahydrobenzoyl, isovaleryl or 2-methylbutyryl, or salts thereof, are useful as antitumor antibiotics. These compounds are produced by culturing a trienomycin- producing microorganism belonging to genus Streptomyces, such as Streptomyces sp. 83-16 FERM BP-939.摘要翻译： 其中R为六氢苯甲酰基，异戊酰基或2-甲基丁酰基或其盐的式（I）...
的三烯霉素可用作抗肿瘤抗生素。 这些化合物通过培养属于链霉菌属（Streptomyces），例如链霉菌属（Streptomyces sp。）的三霉素生产微生物产生。 83-16 FERM BP-939。 -
公开(公告)号：EP4397750A1
公开(公告)日：2024-07-10
申请号：EP22864731.9
申请日：2022-09-02
发明人： SAEGUSA, Chika , FUJIOKA, Masato , OKANO, Hideyuki
摘要： The present invention provides a technology for creating functional inner ear stria vascularis marginal cells that are potentially applicable for screening of agents and pathological analysis of hearing impairment. A method for producing inner ear stria vascularis marginal cells includes a step of culturing a cell population including inner ear progenitor cells in an insulin-free culture medium that does not contain insulin or contains insulin only in a trace amount.
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公开(公告)号：EP3808365B1
公开(公告)日：2024-01-31
申请号：EP20184066.7
申请日：2012-12-14
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公开(公告)号：EP3205713B1
公开(公告)日：2022-06-15
申请号：EP15848739.7
申请日：2015-10-07
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公开(公告)号：EP3508216A1
公开(公告)日：2019-07-10
申请号：EP17846744.5
申请日：2017-09-04
申请人： Hokusan Co. Ltd. , National Institute of Advanced Industrial Science and Technology , School Juridical Person The Kitasato Institute
发明人： TABAYASHI, Noriko , GOTANDA, Toru , SASAKI, Hanae , ITCHODA, Noriko , KAGAYA, Uiko , MATSUMURA, Takeshi , ITO, Akira , IKADAI, Hiromi
IPC分类号： A61K39/015 , C07K14/445 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09
摘要： It is an object of the present invention to provide a transmission-blocking vaccine using an immunogenic protein which is specifically expressed in the oocyst stage of malaria parasites or a peptide fragment thereof, and an oral transmission-blocking vaccine capable of immunizing various animals involved in the malaria infectious cycle with such a vaccine.
The present invention relates to a malaria transmission-blocking vaccine for oral administration containing an immunogenic protein derived from malaria parasite which is specifically expressed in the oocyst stage of malaria parasites or a peptide fragment thereof, and a method of blocking the transmission of malaria using the same.
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