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公开(公告)号：EP2619700B8
公开(公告)日：2019-06-26
申请号：EP11826255.9
申请日：2011-09-22
申请人： Zymeworks Inc.
发明人： OHRN, Anders
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公开(公告)号：EP3004174B1
公开(公告)日：2019-04-17
申请号：EP14803370.7
申请日：2014-05-30
申请人： Zymeworks Inc.
IPC分类号： C07K16/46 , A61K39/395 , C07K16/00 , C07K16/28 , C12N15/13
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公开(公告)号：EP2904093B1
公开(公告)日：2019-04-10
申请号：EP13843363.6
申请日：2013-10-03
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64.发明授权
公开(公告)号：EP2245571B1
公开(公告)日：2019-04-10
申请号：EP09708274.7
申请日：2009-02-05
申请人： Zymeworks Inc.
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公开(公告)号：EP2885736B1
公开(公告)日：2018-10-03
申请号：EP13829560.5
申请日：2013-08-16
申请人： Zymeworks, Inc.
发明人： DIXIT, Surjit B.
IPC分类号： G06F19/16
CPC分类号： G06F19/12 , G06F17/10 , G06F19/16 , G06F19/701
摘要： Systems and methods for searching conformation space of a polymer to determine a three-dimensional conformation of the polymer that satisfies a performance metric is provided. The polymer comprises a plurality of domains and at least a first hinge. Initial three-dimensional coordinates of the polymer are altered by pivoting the first domain with respect to the second domain about the first hinge thereby obtaining an altered set of three-dimensional coordinates for the polymer. In this altering, atoms within the first domain are held fixed with respect to each other and atoms within the second domain are also held fixed with respect to each other. The altered set of coordinates is scored against a performance metric. Additional instances of the altering and scoring are performed, if necessary, until the altered set of three-dimensional coordinates satisfy the performance metric.
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66.发明公开
公开(公告)号：EP3359576A1
公开(公告)日：2018-08-15
申请号：EP16852954.3
申请日：2016-10-07
申请人： Zymeworks Inc.
CPC分类号： C07K16/46 , C07K16/244 , C07K16/32 , C07K16/468 , C07K2299/00 , C07K2317/21 , C07K2317/31 , C07K2317/515 , C07K2317/55 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C12N15/63 , C12P21/00
摘要： Provided herein are multispecific antigen-binding polypeptide constructs comprising at least two different heterodimers, each comprising a heavy chain and a light chain. At least one heterodimer comprises a Fab region comprising a lambda light chain and at least one heterodimer comprises a Fab region comprising a kappa light chain. One or more of the immunoglobulin heavy and light chains that form the antigen-binding polypeptide construct comprise amino acid modifications that promote correct pairing between the heavy and light chains to form the desired multispecific antigen-binding polypeptide construct. The amino acid modifications may be in the CH1 and/or CL domains, in the VH and/or VL domains, or a combination thereof.
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公开(公告)号：EP3194421A4
公开(公告)日：2018-06-06
申请号：EP15842388
申请日：2015-09-17
申请人： ZYMEWORKS INC
发明人： WINTERS GEOFFREY C , RICH JAMES R , GARNETT GRAHAM ALBERT EDWIN , MANDEL ALEXANDER LAURENCE , HSIEH TOM HAN HSIAO , BOURQUE ELYSE MARIE JOSEE , BARNSCHER STUART DANIEL
CPC分类号： C07K16/2887 , A61K38/00 , A61K38/06 , A61K47/48569 , A61K47/48584 , A61K47/4863 , A61K47/54 , A61K47/6855 , A61K47/6867 , C07K5/0205 , C07K16/2878 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/73
摘要： Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
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公开(公告)号：EP3322735A1
公开(公告)日：2018-05-23
申请号：EP16823604.0
申请日：2016-07-15
申请人： Zymeworks Inc.
CPC分类号： A61K47/6803 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6811 , A61K47/6817 , A61K47/6849 , A61K47/6855 , A61K47/6869 , A61K51/1027 , A61K51/103 , A61K51/1042 , A61K51/1051 , A61K51/1072 , A61K2039/505 , A61K2039/572 , A61P35/00 , A61P35/02 , A61P35/04 , C07K16/28 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/32 , C07K16/46 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/71 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C40B40/02 , C40B40/08
摘要： Bispecific antigen-binding constructs e.g., antibodies conjugated to drugs (ADCs), which bind CD3 and other cell-surface target antigen such as tumor antigens e.g., CD19, CDH3, HER2, HER3 and EGFR antigens and methods of use are disclosed.
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公开(公告)号：EP2914634B1
公开(公告)日：2017-12-06
申请号：EP13851307.2
申请日：2013-10-31
申请人： Zymeworks Inc.
发明人： SPRETER VON KREUDENSTEIN, Thomas , DIXIT, Surjit Bhimarao , LARIO, Paula Irene , ESCOBAR-CABRERA, Eric , BOULANGER, Martin J. , SUITS, Michael D.L.
IPC分类号： C07K16/46 , A61K39/395 , G06F19/16 , C07K16/28
CPC分类号： C07K16/00 , C07K16/2887 , C07K16/32 , C07K2299/00 , C07K2317/524 , C07K2317/526 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94 , G06F19/16
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70.发明公开BI-SPECIFIC CD3 AND CD19 ANTIGEN-BINDING CONSTRUCTS 审中-公开BISPEZIFISCHE CD3-UND CD19-ANTIGENBINDENDE KONSTRUKTE
公开(公告)号：EP3094737A4
公开(公告)日：2017-08-09
申请号：EP15736982
申请日：2015-01-15
申请人： ZYMEWORKS INC
CPC分类号： C07K16/2809 , A61K39/39541 , A61K2039/505 , C07K16/2803 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/565 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N2510/02
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