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61.发明公开METHOD FOR PRODUCTION OF NON-NATURAL ANTIBIOTIC 有权VERFAHREN ZUR HERSTELLUNG NICHTNATÜRLICHERANTIBIOTIKA
公开(公告)号：EP2192171A1
公开(公告)日：2010-06-02
申请号：EP08830223.7
申请日：2008-09-12
发明人： SUMIDA, Naomi , WATANABE, Manabu , YANAI, Koji
IPC分类号： C12N1/21 , C12N15/09 , C12P19/56 , C07H15/252 , C12R1/465
CPC分类号： C12P19/56 , C12N9/0006 , C12P17/06 , C12P19/44
摘要： Disclosed is a transformant prepared by introducing a ketoreductase gene involved in the biosynthesis of L-epivancosamine into an actinobacterium originally capable of producing daunorubicin. Also disclosed is a process of efficiently producing a non-natural daunorubicin derivative using the transformant. The transformant is capable of efficiently producing a non-natural daunorubicin derivative such as epidaunorubicin.
摘要翻译： 公开了通过将参与L-赖氨替康的生物合成的酮还原酶基因导入原本能产生柔红霉素的放线杆菌中制备的转化体。 还公开了使用转化体有效生产非天然柔红霉素衍生物的方法。 转化体能够有效地产生非天然柔红霉素衍生物如表柔比星。
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62.发明授权Genetically modified Streptomyces strains for biotransformations in anthracycline production 有权在蒽环类生产遗传修饰链霉菌的菌株的生物转化
公开(公告)号：EP2042608B1
公开(公告)日：2010-02-03
申请号：EP07016622.8
申请日：2007-08-24
申请人： W.C. Heraeus GmbH
IPC分类号： C12P19/56
CPC分类号： C12P19/56
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63.发明授权A PROCESS FOR THE BIOTRANSFORMATION OF COLCHICONE COMPOUNDS INTO THE CORRESPONDING 3-GLYCOSYL DERIVATIVES 有权PROCEDURE生物转化colchicone化合物在相关3-糖基衍生物
公开(公告)号：EP1019521B1
公开(公告)日：2006-05-31
申请号：EP98952675.1
申请日：1998-09-30
申请人： INDENA S.p.A.
发明人： BOMBARDELLI, Ezio , PONZONE, Cesare
CPC分类号： C12P19/56
摘要： Colchiconic compounds are transformed into the corresponding 3-O-glycosyl derivatives by means of Bacillus megaterium strains.
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64.发明公开ADENOSYLMETHIONINE SYNTHETASE FROM STREPTOMYCES SP., GENE SEQUENCES CODING THE SAME AND METHOD FOR MASS PRODUCTION OF SECONDARY METABOLITES INCLUDING ANTIBIOTICS THEREOF 审中-公开从链霉菌腺苷甲硫氨酸合成，二次代谢产物包括抗生素种的大量生产这种编码基因序列和方法
公开(公告)号：EP1417313A1
公开(公告)日：2004-05-12
申请号：EP02758891.2
申请日：2002-07-16
IPC分类号： C12N15/54
CPC分类号： C12N9/1085 , C12P13/02 , C12P13/08 , C12P19/445 , C12P19/54 , C12P19/56 , C12P19/623 , C12P29/00 , C12Y205/01006
摘要： Disclosed is an isolated nucleotide sequence encoding an enzyme catalyzing biosynthesis of SAM (SAM-s) and its amino acid sequence. Also, the present invention provides a method for mass production of a useful secondary metabolite including antibiotics using the isolated nucleotide sequence and SAM, where SAM acts as a methyl group donor.
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公开(公告)号：EP1071746A2
公开(公告)日：2001-01-31
申请号：EP99919767.6
申请日：1999-04-22
发明人： SOLARI, Augusto, Inventi , ZANUSO, Giovanna , FILIPPINI, Silvia , TORTI, Francesca , OTTEN, Sharee , COLOMBO, Anna, Luisa , HUTCHINSON, Charles, R.
IPC分类号： C12N1/00
CPC分类号： C12N9/0071 , C12P19/56
摘要： The ability to convert daunorubicin into doxorubicin can be improved by transforming a host cell with a recombinant vector comprising a DNA molecule comprising: a DNA region or fragment containing the gene doxA encoding daunorubicin 14-hydroxylase and a DNA region or fragment containing one or more gene conferring daunorubicin and doxorubicin resistance.
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66.发明公开A PROCESS FOR THE BIOTRANSFORMATION OF COLCHICONE COMPOUNDS INTO THE CORRESPONDING 3-GLYCOSYL DERIVATIVES 有权PROCEDURE生物转化colchicone化合物在相关3-糖基衍生物
公开(公告)号：EP1019521A1
公开(公告)日：2000-07-19
申请号：EP98952675.1
申请日：1998-09-30
申请人： INDENA S.p.A.
发明人： BOMBARDELLI, Ezio , PONZONE, Cesare
IPC分类号： C12P19/56
CPC分类号： C12P19/56
摘要： Colchiconic compounds are transformed into the corresponding 3-O-glycosyl derivatives by means of Bacillus megaterium strains.
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公开(公告)号：EP0763112B1
公开(公告)日：1999-04-07
申请号：EP96904823.0
申请日：1996-02-20
发明人： SOLARI INVENTI, Augusto , BREME, Umberto , COLOMBO, Anna, Luisa , HUTCHINSON, Charles, Richard , OTTEN, Sharee , SCOTTI, Claudio
CPC分类号： C12N9/0071 , C12P19/56
摘要： The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can then be used to produce doxorubicin.
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公开(公告)号：EP0901493A1
公开(公告)日：1999-03-17
申请号：EP97923847.0
申请日：1997-05-06
申请人： Glaxo Wellcome S.A.
发明人： CALDERON, Jose Maria Bueno, Glaxo Wellcome S.A. , CHICHARRO GONZALO, Jesus, Glaxo Wellcome S.A. , FIANDOR ROMAN, Jose, Glaxo Wellcome S.A. , HUSS, Sophie, Glaxo Wellcome S.A. , RUDD, Brian, Arthur, Michael, Glaxo Wellcome plc
CPC分类号： C07D493/04 , C07D309/30 , C07F7/1856 , C12P19/56
摘要： A process for the preparation of compound (I) and novel intermediates for use in the process.
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69.发明授权Cyathane derivatives and production stimulators of nerve growth factors and antimicrobial agents containing same 失效Cyathane衍生物和含有神经生长因子产生刺激剂和抗微生物剂
公开(公告)号：EP0613903B1
公开(公告)日：1997-05-21
申请号：EP94301549.5
申请日：1994-03-03
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公开(公告)号：EP0599646A2
公开(公告)日：1994-06-01
申请号：EP93309412.0
申请日：1993-11-25
IPC分类号： C12P19/02 , C12P19/56 , C12P19/04 , C12P19/12 , C07H15/24 , C08B37/16 , C08B31/18 , C08B37/02 , C12P19/00
CPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof is characterised in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artefact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid, and the carboxylic acid so accumulated is harvested; novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield; the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.
摘要翻译： 糖羧酸或其盐的制造方法的特征在于，属于假葡糖杆菌属的能够将羟甲基和/或半缩醛羟基相关碳原子氧化成羧基的微生物或衍生自 微生物被允许作用于羟甲基和/或半缩醛羟基的糖或糖衍生物以产生并累积相应的羧酸，并收集如此积累的羧酸; 通过上述制备方法制备的新型糖类羧酸，并且通过该方法可以从高范围的糖类获得具有羟基甲基和/或半缩醛OH基团的具有羧基的糖酸，并且以高的选择性和良好的收率生产; 所产生的糖酸对酶降解具有抗性，并具有改善的水溶性等特性。
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