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    SOLID DOSAGE FORMULATIONS OF HYDRALAZINE COMPOUNDS
    62.
    发明公开
    SOLID DOSAGE FORMULATIONS OF HYDRALAZINE COMPOUNDS 审中-公开
    肼类化合物的固体剂量配方

    公开(公告)号：EP2024337A1

    公开(公告)日：2009-02-18

    申请号：EP07777070.9

    申请日：2007-05-16

    申请人： Nitromed, Inc.

    发明人： LETTS, L., Gordon

    IPC分类号： C07D237/26 ,  A01N25/34

    CPC分类号： A61K9/2054 ,  A61K9/2059 ,  A61K31/34 ,  A61K31/502 ,  A61K45/06 ,  Y02A50/411 ,  A61K2300/00

    摘要： The invention provides solid dosage formulations, methods of making and using the formulations comprising at least one hydralazine compound or a pharmaceutically acceptable salt thereof, and at least one excipient or carrier, wherein the formulations have less than about 0.001% to about 0.1% of a hydrazone compound based on the total weight of the formulation. The invention also provides solid dosage formulations, methods of making and using the formulations comprising at least one hydralazine compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor compound or a pharmaceutically acceptable salt thereof and at least one excipient or carrier, wherein the formulations have less than about 0.001% to about 0.1% of a hydrazone compound based on the total weight of the formulation.

    摘要翻译： 本发明提供了固体剂型，制备和使用包含至少一种肼屈嗪化合物或其药学上可接受的盐和至少一种赋形剂或载体的制剂的方法，其中所述制剂具有小于约0.001％至约0.1％的 腙化合物，基于配方的总重量。 本发明还提供固体剂量制剂，制备和使用包含至少一种肼屈嗪化合物或其药学上可接受的盐和至少一种一氧化氮供体化合物或其药学上可接受的盐以及至少一种赋形剂或载体的制剂的方法， 其中所述制剂具有基于所述制剂的总重量小于约0.001％至约0.1％的腙化合物。