公开(公告)号：EP2322178A2

公开(公告)日：2011-05-18

申请号：EP10191018.0

申请日：2010-11-12

申请人： Oregon Health & Science University

发明人： Stenzel-Poore, Mary, M. ,  Stevens, Susan, M.

IPC分类号： A61K31/4745 ,  A61K31/7125 ,  A61P9/10

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/7088 ,  A61K31/7125 ,  A61K31/713 ,  A61K31/715 ,  A61K38/12 ,  A61K38/17

摘要： Methods of protecting cells against cytotoxic insults are provided. The methods involve administering a composition including a Toll-like receptor (TLR) ligand, for instance a TLR7, TLR8, or TLR9 ligand to a subject. The methods are applicable to the protection of neural and non-neural cells. For example, methods of protecting a neural cell against excitotoxic brain injury are provided. Methods for preparing medicaments for the prophylactic treatment of excitotoxic injury, ischemia and/or hypoxia are also provided. Also provided are compositions for use in the described methods.

摘要翻译： 提供保护免受毒性损伤细胞的方法。 该方法涉及施用组合物包括Toll样受体（TLR）配体，例如是TLR7，TLR8，TLR9或配体施用于受试者。 该方法适用于神经和非神经细胞的保护作用。 对于实施例，提供了保护免受兴奋毒性脑损伤神经细胞的方法。 因此，提供用于制备药物用于兴奋性毒性损伤，局部缺血和/或缺氧的预防性治疗方法。 那么，在描述的方法使用提供的组合物。

公开(公告)号：EP2222707A2

公开(公告)日：2010-09-01

申请号：EP08852770.0

申请日：2008-11-21

申请人： Oregon Health & Science University ,  Vanderbilt University

发明人： GRUBER, Andras ,  TUCKER, Erik, Ian ,  HANSON, Stephen, Raymond ,  GAILANI, David

IPC分类号： C07K16/36

CPC分类号： C07K16/36 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2316/96 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier. Methods of the invention comprise administering the compositions described above to a subject in need thereof for the purpose of inhibiting thrombosis, reducing a required dose of an antithrombotic agent in the treatment of thrombosis, treating metastatic cancer, or treating an acute inflammatory reaction. Methods for making an anti-factor XI monoclonal antibody, or epitope-binding fragments, variants, or derivatives thereof, are also provided.

公开(公告)号：EP1951294A1

公开(公告)日：2008-08-06

申请号：EP06837336.4

申请日：2006-11-09

申请人： Athersys, Inc. ,  OREGON HEALTH SCIENCE UNIVERSITY

发明人： DEANS, Robert ,  VAN'T HOF, Wouter ,  MAZIARZ, Richard ,  KOVACSOVICS, Magdalena ,  STREETER, Philip

IPC分类号： A61K39/00 ,  A61K35/28 ,  A61P37/06

摘要： Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.

摘要翻译： 描述了不是胚胎干细胞，而不是胚胎生殖细胞，而不是生殖细胞的分离的细胞。 细胞可以分化为至少两种内胚层，外胚层和中胚层谱系中的至少一种细胞类型。 细胞不会引起有害的免疫反应。 细胞可以调节免疫反应。 作为示例，细胞可以抑制由同种异体细胞，组织和器官产生的宿主中的免疫应答。 描述了使用细胞本身或辅助地治疗受试者的方法。 例如，细胞可以辅助地用于移植治疗中的免疫抑制。 还描述了获得细胞和使用它们的组合物的方法。

公开(公告)号：EP1568770A3

公开(公告)日：2005-11-30

申请号：EP04030304.2

申请日：2001-09-12

申请人： Oregon Health & Science University

发明人： Bunzow, James R. ,  Grandy, David K.

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12Q1/68 ,  G01N33/566 ,  A61K31/13 ,  A61P25/18 ,  A61P25/24 ,  A61P25/30 ,  A61P9/12 ,  A61P11/06 ,  A61P29/00

CPC分类号： C07K14/70571 ,  A61K38/00

摘要： The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention provides methods for screening compounds in vitro that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.

摘要翻译： 本发明涉及新的哺乳动物生物胺受体蛋白和基因确实编码的蛋白质检测。 本发明提供了在体外筛选化合物的方法做了能够结合到哺乳动物痕量胺发明受体蛋白，以及它们的与已知的痕量胺受体激动剂和拮抗剂的比较进一步表征测试的化合物和功能后果的结合特性。 由此提供改善的药理学筛选方法。

公开(公告)号：EP1568770A2

公开(公告)日：2005-08-31

申请号：EP04030304.2

申请日：2001-09-12

申请人： Oregon Health & Science University

发明人： Bunzow, James R. ,  Grandy, David K.

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12Q1/68 ,  G01N33/566 ,  A61K31/13 ,  A61P25/18 ,  A61P25/24 ,  A61P25/30 ,  A61P9/12 ,  A61P11/06 ,  A61P29/00

CPC分类号： C07K14/70571 ,  A61K38/00

摘要： The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention provides methods for screening compounds in vitro that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.

摘要翻译： 本发明涉及新的哺乳动物生物胺受体蛋白质和编码这种蛋白质的基因。 本发明提供了用于体外筛选能够结合本发明的哺乳动物微量胺受体蛋白的化合物的方法，并进一步表征了这些化合物的结合特性及其与已知的痕量胺受体激动剂和拮抗剂相比的功能结果。 由此提供了改进的药理筛选方法。

公开(公告)号：EP1476153A2

公开(公告)日：2004-11-17

申请号：EP03704519.2

申请日：2003-02-03

申请人： F. Hoffmann-La Roche AG ,  The Government of the United States ,  Oregon Health & Science University

发明人： ALLARD, John, David ,  KLEIN, Robert, Frederick ,  PELTZ, Gary, Allen

IPC分类号： A61K31/407 ,  A61K31/404 ,  A61K31/192 ,  A61K31/167 ,  A61P19/10 ,  A61P19/08 ,  A61P19/02

CPC分类号： C12Q1/26 ,  A61K31/167 ,  A61K31/192 ,  A61K31/404 ,  A61K31/407 ,  A61K31/56 ,  A61K31/663 ,  A61K38/23 ,  A61K38/30 ,  G01N2333/90241 ,  G01N2500/04 ,  G01N2800/108 ,  A61K2300/00

摘要： Methods of treating and preventing bone loss and/or enhancing bone formation are disclosed. The methods utilize 15-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with agents which inhibit bone resorption or additional agents that regulate calcium resorption from bone or enhances bone accumulation. The invention additionally provides methods of diagnosing a predisposition to bone loss.

公开(公告)号：EP1436384A2

公开(公告)日：2004-07-14

申请号：EP02782829.2

申请日：2002-10-04

申请人： Novartis AG ,  Université Victor Segalen Bordeaux 2 ,  Technische Universität München ,  Oregon Health & Science University ,  Universität Heidelberg ,  CHRU DE LILLE,centre Hospitalier Regional Universitaire de Lille ,  MEDVET SCIENCE PTY. LTD.

发明人： BARTHE, Christophe ,  BRANFORD, Susan ,  CORBIN, Amie ,  DRUKER, Brian, Jay ,  DUYSTER, Justus ,  HOCHHAUS, Andreas ,  HUGHES, Timothy ,  KREIL, Sebastian ,  LEGUAY, Thibaut ,  MAHON, François-Xavier ,  MARIT, Gérald ,  MÜLLER, Martin ,  PESCHEL, Christian ,  PREUDHOMME, Claude ,  ROCHE LESTIENNE, Catherine ,  RUDZKI, Zbigniew

IPC分类号： C12N9/12

CPC分类号： C12N9/1205

摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

公开(公告)号：EP1411964A2

公开(公告)日：2004-04-28

申请号：EP02746923.8

申请日：2002-07-08

申请人： OREGON HEALTH SCIENCE UNIVERSITY

发明人： FARREL, David, H. ,  LOVELY, Rehana, S.

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K35/14 ,  C07K16/00 ,  A01N37/18 ,  G01N33/53

CPC分类号： C07K14/75 ,  A61K38/00

摘要： Peptide fragments that modulate thrombosis and methods of use thereof are provided. Also provided are synthetic bioactive anti-coagulation peptides, compositions comprising such peptides and methods for the administration to patients in need thereof.

公开(公告)号：EP3843726B1

公开(公告)日：2024-02-28

申请号：EP19855560.9

申请日：2019-08-23

发明人： COHEN, Michael ,  KIRBY, Ilsa

IPC分类号： C07D403/02 ,  A61K31/435 ,  A61P35/00

公开(公告)号：EP3259246B1

公开(公告)日：2023-03-22

申请号：EP16753172.2

申请日：2016-02-19

发明人： SCANLAN, Thomas ,  PLACZEK, Andrew ,  BANERJI, Tapasree ,  FERARRA, Skylar ,  MEINIG, James Matthew

IPC分类号： C07C69/736 ,  C07C219/06 ,  C07C229/36 ,  C07C235/06 ,  C07C237/08 ,  C07D205/04 ,  C07D207/08 ,  C07D211/22 ,  C07D211/42 ,  C07D211/44 ,  C07D233/64 ,  C07D295/088 ,  C07D309/10 ,  C07H13/04 ,  A61K31/216 ,  A61K31/221 ,  A61K31/397 ,  A61P25/00