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147 条记录 (耗时 0.014 秒)

    Synthetic peptide endowed with immunological activity, capable of inducing the production of antibodies with a high specificity towards alpha-fetoprotein, and their use in the diagnostic field
    71.
    发明公开
    Synthetic peptide endowed with immunological activity, capable of inducing the production of antibodies with a high specificity towards alpha-fetoprotein, and their use in the diagnostic field 失效
    合成肽具有免疫活性，从而促进了生产与抗甲胎蛋白高特异性，以及它们在诊断领域使用抗体。

    公开(公告)号：EP0353814A2

    公开(公告)日：1990-02-07

    申请号：EP89201926.6

    申请日：1989-07-21

    申请人： SCLAVO S.p.A.

    发明人： Tecce, Mario Felice ,  Giuliani, Marzia Monica ,  Ricci, Stefano ,  Ratti, Giulio ,  Terrana, Benedetto

    IPC分类号： C07K7/10 ,  C12N15/00 ,  G01N33/53

    CPC分类号： C12N9/1252 ,  C07K14/4715 ,  C07K16/30 ,  C07K16/303 ,  C07K2319/00 ,  C07K2319/30

    摘要： A synthetic peptide endowed with immunological activity is disclosed, which is capable of inducing in mammals the formation of anti-peptide antibodies capable of recognizing human alpha-fetoprotein and of reacting with it, and incapable of recognizing albumin or its degradation products, with said peptide being essentially constituted by the aminoacidic sequence of formula (I), corresponding to 38- 119 region of human alpha-­fetoprotein.
    Furthermore, the methods and means for preparing said peptide by means of the recombinant DNA techniques are reported.
    The synthetic peptide (I), like the polyclonal and monoclonal antipeptide antibodies are particularly suitable for the early diagnosis of hepatocellular carcinoma and of teratocarcinoma.

    摘要翻译： 赋有免疫学活性的合成肽是圆盘游离缺失，所有其能够在哺乳动物中诱导能够识别人甲胎蛋白和与之发生反应的抗肽抗体的形成，并且不能识别白蛋白或其降解产物的，与所述肽 基本上由式（I）的aminoacidic序列构成的，对应于38-人甲胎蛋白的119区域。 进一步，用于制备和手段的方法的由所述的重组DNA技术的肽的报道。 合成肽（I），如多克隆抗体和单克隆抗肽抗体特别适合用于畸胎癌的肝细胞癌和早期诊断。

    A protective immunodominant epitope included in the S1 subunit of pertussis toxin
    73.
    发明公开
    A protective immunodominant epitope included in the S1 subunit of pertussis toxin 失效
    Schützendes独立主义者在S1-Untereinheit von Pertussistoxin中的Epitop。

    公开(公告)号：EP0320866A2

    公开(公告)日：1989-06-21

    申请号：EP88120779.9

    申请日：1988-12-13

    申请人： SCLAVO S.p.A.

    发明人： Bartoloni, Antonella ,  Pizza, Mariagrazia ,  Rappuoli, Rino

    IPC分类号： C07K13/00 ,  C12N15/00 ,  A61K39/10

    CPC分类号： C07K14/235 ,  A61K39/00

    摘要： There are described a protective immunodominant epitope of pertussis toxin which is included in the S1 subunit, and synthetic peptides with an aminoacid sequence similar to that of the epitope or to regions thereof which show an immunochemical reactivity with anti-PT protective monoclonal antibodies equivalent to that of the protein itself. Ihe peptides are particularly useful for the preparation of an antipertussis vaccine.

    摘要翻译： 描述了包含在S1亚基中的百日咳毒素的保护性免疫优势表位，以及具有与表位或其表位与抗PT保护性单克隆抗体相当的免疫化学反应性的氨基酸序列的氨基酸序列的合成肽 的蛋白质本身。 肽类特别可用于制备抗百日咳疫苗。

    Method for the immunolocalization of antigens
    75.
    发明公开
    Method for the immunolocalization of antigens 失效
    抗原免疫化学方法

    公开(公告)号：EP0306082A3

    公开(公告)日：1989-05-24

    申请号：EP88201812.0

    申请日：1988-08-25

    申请人： SCLAVO S.p.A.

    发明人： Ruggiero, Paolo ,  Petracca, Roberto

    IPC分类号： G01N33/543 ,  G01N33/58

    CPC分类号： G01N33/581 ,  G01N2001/2846 ,  Y10S435/81 ,  Y10S435/96 ,  Y10S436/825 ,  Y10S436/827

    摘要： A method is given for the immunolocalization of epitopes of non-glucidic nature, in cellular cultures, in tissue slices, or immobilized on such supports as nitrocellulose, by means of the incubation of the sample with specific antibodies for the antigen to be immunolocalized, belonging to the class of the IgM's, and sequential treatment of concanavalin A and with an enzymatic marker capable of binding with concanavalin A, such as, e.g., peroxidase. The method comprises, before the incubation, a suitable treatment of the sample under test, e.g., with periodic acid, in order to prevent concanavalin A from binding with the carbohydrates present in the sample.

    Synthetic peptide with human interleukin 1 activity
    76.
    发明公开
    Synthetic peptide with human interleukin 1 activity 失效
    具有人类白细胞介素1活性的合成肽

    公开(公告)号：EP0231728A3

    公开(公告)日：1989-05-03

    申请号：EP86830299.3

    申请日：1986-10-17

    申请人： SCLAVO S.p.A.

    发明人： Tagliabue, Aldo ,  Boraschi, Diana ,  Antoni, Guido ,  Presentini, Rivo

    IPC分类号： C07K7/06 ,  A61K37/02

    CPC分类号： C07K14/545 ,  Y10S514/885 ,  Y10S930/141

    摘要： Synthetic peptide with human interleukin 1 acti­vity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula:
        Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X      (I)
    where:
    Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.

    Pharmaceutical composition for intrarectal administration of a calcitonin and unit dosage forms prepared therefrom
    77.
    发明公开
    Pharmaceutical composition for intrarectal administration of a calcitonin and unit dosage forms prepared therefrom 失效
    降钙素的直肠内给药和衍生的单位剂量形式的药物制剂。

    公开(公告)号：EP0308725A2

    公开(公告)日：1989-03-29

    申请号：EP88114598.1

    申请日：1988-09-07

    申请人： SCLAVO S.p.A.

    发明人： Lattanzi, Filippo ,  Vanni, Riccardo

    IPC分类号： A61K47/00 ,  A61K9/02 ,  A61K37/30

    CPC分类号： A61K38/23 ,  A61K9/0031 ,  A61K9/4841

    摘要： New compositions containing a calcitonin as the active ingredient are described which are suitable for the intrarectal administration as soft gelatin capsules or microenemas, wherein the active principle, optionally admixed with a stabilizer, is dissolved in a liquid vehicle consisting of : a) at least 70 % by weight of a polyethylene or a polypropylene glycol or a mixture of polyethylene or polypropylene glycols with different molecular weights, having the consistency of a homogeneous fluid at room temperature, and b) less than 15 % by weight of a buffer in a pH range of from 4.5 to 6.5, and optionally c) less than 15 % by weight of an alcohol of 2 to 6 carbon atoms containing two or more hydroxy groups.
    The new compositions, which do not contain any absorption aid, give calcitonin plasma levels comparable to a conventional intramuscular administration.

    摘要翻译： 含降钙素作为活性成分的新的组合物，描述了适合于直肠内给药的软明胶胶囊或microenemas，worin活性成分，与稳定剂OPTIONALLY混合，在液体载体中由...组成的溶解：a）至少70 ％（重量）的聚乙烯或聚丙二醇或聚乙烯或具有不同分子量的聚丙二醇的混合物，在室温下具有均匀的流体的连贯性，以及b）小于15％（重量）的缓冲液的pH范围内 的4.5至6.5，和任选的c）按重量计含两个或多个羟基基团的2-6个碳原子的醇的小于15％。 新组合物，其不包含任何吸收援助，给予相当于传统肌肉注射降钙素血浆水平。

    A synthetic nonapeptide of use as an adjuvant
    78.
    发明公开
    A synthetic nonapeptide of use as an adjuvant 失效
    Ein synthetisches Nonapeptid zur Verwendung als佐剂。

    公开(公告)号：EP0293333A2

    公开(公告)日：1988-11-30

    申请号：EP88830056.3

    申请日：1988-02-16

    申请人： SCLAVO S.p.A.

    发明人： Nencioni, Luciano ,  Antoni, Guido ,  Boraschi, Diana ,  Tagliabue, Aldo

    IPC分类号： A61K37/02

    CPC分类号： C07K14/545 ,  A61K39/39 ,  A61K2039/55516

    摘要： The specification relates to a synthetic peptide converted into a salt comprising one or more amine groups and capable of potentiating in vivo the primary and secondary antibody response to thymo-­dependent and thymo-independent antigens having low immunogenicity.
    Injectable preparations comprising a solution of the peptide in a pharmacologically acceptable solvent are particularly useful as adjuvants in therapy.

    摘要翻译： 该说明书涉及转化成包含一个或多个胺基并且能够增强体内抗细胞免疫原性低的胸腺依赖性和不依赖于胸腺的抗原的一级和二级抗体的合成肽。 包含肽在药理学上可接受的溶剂中的溶液的可注射制剂特别可用作治疗中的佐剂。