公开(公告)号：EP1620077A2

公开(公告)日：2006-02-01

申请号：EP04750850.2

申请日：2004-04-28

申请人： Shear/Kershman Laboratories, Inc.

发明人： KERSHMAN, Alvin ,  SHEAR, Jeff, L.

IPC分类号： A61K9/22

CPC分类号： A61K9/5047 ,  A61K9/1652 ,  A61K9/2013 ,  A61K9/2095 ,  A61K47/24

摘要： A solid oral delivery system having improved sustained release properties made of at least one lipid, dry particles including at least one pharmaceutical, and at least one filler, wherein the dry particles are continuously coated by the lipid and form a homogeneous suspension with the lipid, wherein the suspension, when melted, exhibits thixotropic and/or pseudoplastic properties, wherein the suspension is formed into the desired dose by molding or pouring the suspension when in a liquid or semi-liquid state. The process for preparing the present delivery system by melting the lipid, blending the dry particles which include the pharmaceutical, at least one filler and, optionally, flavorings with the melted lipid, and pouring or molding the suspension to provide the solid dose, wherein the suspension, when melted, exhibits thixotropic and pseudoplastic flow properties.

公开(公告)号：EP1613721A1

公开(公告)日：2006-01-11

申请号：EP04709770.4

申请日：2004-02-10

申请人： Jeongseon County

发明人： CHOI, Dae-Sung

IPC分类号： C12G3/02

CPC分类号： C12G3/02

摘要： The present invention relates to fermented wines made from fruits of deciduous shrubs or latifoliate shrubs in the family of Aralia elata, especially, fruits of Acanthopanax sessiliflorus or Acanthopanax senticosus as main materials and, a producing method thereof. The present invention makes it possible to produce fermented wines that are much milder than traditional liquors made from roots or stems of Acanthopanax, and have similar characteristics to wines'. Furthermore, the present invention makes the most of pharmacological characteristics of Acanthopanax sufficiently. Accordingly, offering a new method of utilizing fruits of Acanthopanax that have been discarded so far, the present invention results in economic effects by helping increase benefits of farmhouses.

公开(公告)号：EP1597504A1

公开(公告)日：2005-11-23

申请号：EP04709552.6

申请日：2004-02-10

申请人： Truss Holdings Pty. Ltd.

发明人： TRUSS, James, Walter, George

IPC分类号： F16L5/04 ,  F16L57/04

CPC分类号： F16L55/1026 ,  A62C2/065 ,  F16L5/04 ,  Y10T137/1819

摘要： A fire collar (10), for location in a concrete slab (46) around a deformable conduit (14), has a housing with a passageway (16) through which the conduit (14) passes. The collar (10) has a housing (12) in which are located two compression springs (18, 20) with arms (30, 32) which are held against the force of the springs (18, 20) by fusible Iinks (34, 36). When the heat of a fire on one side of the slab (46) causes the fusible links (34, 36) to soften or meit, the force of the springs (18, 20) causes the spring arms (30, 32) to rotate towards the conduit (14), engaging the conduit (14) and collapsing it. An intumescent layer (42) may be provided around the conduit (14) to assist in collapsing it.

摘要翻译： 用于定位在可变形导管（14）周围的混凝土板（46）中的炉箍（10）具有带有通道（16）的壳体，导管（14）穿过该通道。 轴环（10）具有壳体（12），两个压缩弹簧（18,20）位于壳体（12）中，臂（30,32）通过可熔连接件（34,36）抵抗弹簧（18,20） 36）。 当板坯46的一侧上的火焰热量引起易熔连杆34,36软化或勉勉勉强时，弹簧18,20的力导致弹簧臂30,32旋转 朝向导管（14），接合导管（14）并使其塌缩。 可在导管（14）周围设置膨胀层（42）以帮助使其塌陷。

公开(公告)号：EP0891523B1

公开(公告)日：2005-11-09

申请号：EP97922289.0

申请日：1997-04-05

申请人： Worldwide Water, Inc.

发明人： LEBLEU, Terry L. c/o Worldwide Water, Inc ,  FORSBERG, Francis C. ,  LEBLEU, Stephen M.

IPC分类号： F25D17/06

CPC分类号： C02F9/005 ,  B01D5/0072 ,  C02F1/001 ,  C02F1/008 ,  C02F1/283 ,  C02F1/32 ,  C02F1/36 ,  C02F1/78 ,  C02F9/00 ,  C02F2201/009 ,  C02F2209/008 ,  C02F2209/02 ,  C02F2209/40 ,  C02F2209/42 ,  E03B3/28 ,  Y02A20/109 ,  Y02A20/154 ,  Y02A20/211 ,  Y02A20/212 ,  Y02A20/214 ,  Y02W10/37

摘要： A portable, potable-water generator for producing high-purity liquid water by condensation of dew from ambient air. The generator employs filtration subsystems to remove particulates and aerosols from the incoming air. An enclosed heat absorber cools the filtered air to its dew point and collects droplets of condensate into a closed system. The collected dew is further continually treated in a bacteriostat loop to destroy adventitious living organisms and to filter out undesirable and dangerous contaminants. All the subsystems are failsafe-interlocked to disable the generator immediately and prevent delivery of water if any one of them stops functioning within predetermined safe limits.

公开(公告)号：EP1556396A1

公开(公告)日：2005-07-27

申请号：EP03741579.1

申请日：2003-07-15

申请人： Samchully Pharm. Co., Ltd.

发明人： KANG, Jae-Sung ,  YUN, Mi-Hong ,  LEE, Sang-Dae ,  JEON, Byoung-Chan ,  SHIN, Jeong-Ah

IPC分类号： C07H3/02

CPC分类号： C07H3/08 ,  C07H1/00 ,  C07H3/02

摘要： The present invention relates to a economic synthetic method of 2-deoxy-L-ribose from 2-deoxy-D-ribose with easy reaction, separation and purification. The present invention consists of four(4) steps including protection, activation 3-and 4-OH groups, inversion and deprotection step. In respect to the cost for equipment, reagent and operation, by the present invention, 2-deoxy-L-ribose can be produced more economically because the invention uses 2-deoxy-L-ribose which is abundant in nature and easily synthesized from D-glucose, and adopt simple and yielding process.

公开(公告)号：EP1473992A1

公开(公告)日：2004-11-10

申请号：EP03731847.4

申请日：2003-01-23

申请人： Bio Dreams Co., Ltd.

发明人： PARK, Hae-jun

IPC分类号： A01N25/08

CPC分类号： A01N25/08 ,  A01N25/26

摘要： The present invention relates to a stained release composition of a biologically active substance, and a preparation method thereof. The sustained release composition includes an absorbing carrier having 0.0005≈unit by weight of the biologically active substance adsorbed in 1000 unit by weight of a porous carrier, and a sustained release layer having a mixture of 0.05≈unit by weight of polysaccharide, 0.3≈unit by weight of inorganic alkali, and 0.25≈unit by weight of one or more release regulators made of either organic or inorganic acid selected from the group consisting of phosphorous acid, phosphoric acid, acetic acid and hydrochloric acid, the mixture coated on the surface of the adsorbing carrier.

公开(公告)号：EP1403846A1

公开(公告)日：2004-03-31

申请号：EP01934435.7

申请日：2001-05-30

申请人： Singer, Walter ,  Stransky, Lars Michael ,  Kimura, Haruo

发明人： Singer, Walter ,  Stransky, Lars Michael ,  Kimura, Haruo

IPC分类号： G10D9/04 ,  G10D7/10

CPC分类号： G10D7/10 ,  G10D9/04

摘要： Since the casing newly developed for the entire valve block of a brasswind instrument is made of resin, the dimensions of all inner movable parts can be increased without increasing substantially the weight of the entire valve block. This additional degree of freedom in design allows for planning and manufacturing of both inner sound channels and switching channels of movable inner parts so that they have a perfectly circular profile and a smooth inner surface. Therefore, by providing an ideal sound channel without increasing the overall weight of the valve block, a considerable improvement in the sound quality of an instrument can be achieved.

摘要翻译： 由于构成用于乐器的阀装置的壳体由树脂制成，与壳体由金属制成的尺寸相比，可移动构件的尺寸可以大，而不增加阀装置的重量 。 这导致形成在一对开口之间连通的可移动部件中的声通道的形状的任意性的增强，从而可以形成具有完全圆形横截面和平滑内壁的声通道 活动件 这意味着用于乐器的阀装置的重量几乎没有增加，并且由理想的声音通道显着提高了音质。

公开(公告)号：EP1000047B1

公开(公告)日：2003-12-17

申请号：EP98943815.5

申请日：1998-07-31

申请人： RECORDATI S.A. ,  RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.

发明人： LEONARDI, Amedeo ,  MOTTA, Gianni ,  RIVA, Carlo ,  TESTA, Rodolfo

IPC分类号： C07D295/12 ,  C07D307/68 ,  C07D295/22 ,  C07D333/38 ,  C07D213/81 ,  C07D213/82 ,  C07D241/24 ,  C07D209/08 ,  A61K31/495

CPC分类号： C07D213/81 ,  C07D209/08 ,  C07D213/82 ,  C07D241/24 ,  C07D295/13 ,  C07D295/24 ,  C07D307/68 ,  C07D333/38

摘要： 1-(N-phenylaminoalkyl)-piperazine derivatives of formula (I), (R = H, alkyl-CO, cycloalkyl-CO, substituted cycloalkyl-CO or monocyclic heteroaryl-CO; R1 = H or lower alkyl; R2 = halogen, alkoxy, phenoxy, NO2, CN, acyl, NH2, NH(acyl), alkyl-SO2NH, alkoxycarbonyl, NH2CO, (alkyl)NHCO, (alkyl)2NCO, (acyl)NHCO, CF3 or polyfluoroalkoxy; B = benzyl or mono- or bicyclic aryl or heteroaryl, all optionally substituted) bind to 5HT1A receptors and are useful for the treatment of neuromuscular dysfunctions of the lower urinary tract. The use of these compounds for the preparation of a medicament for this treatment is claimed, and some of the compounds (with restricted B values) are claimed per se.

公开(公告)号：EP1200445B1

公开(公告)日：2003-09-17

申请号：EP00958313.9

申请日：2000-07-28

申请人： RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. ,  RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY

发明人： LEONARDI, Amedeo ,  MOTTA, Gianni ,  RIVA, Carlo ,  TESTA, Rodolfo

IPC分类号： C07D495/04 ,  A61K31/496 ,  A61P9/00

CPC分类号： C07D495/04

摘要： Compounds (I) (R = aryl, cycloalkyl or polyhaloalkyl, R1 = alkyl, alkoxy, polyfluoroalkoxy, hydroxy or trifluoromethanesulphonyloxy, each of R2 and R3 independently = H, halogen, alkoxy or polyfluoroalkoxy, n is 0, 1 or 2) and their N-oxides or pharmaceutically acceptable salts are endowed with enhanced selectivity for the α1 adrenergic receptor and a low activity in lowering blood pressure. This activity profile makes these compounds useful in the treatment of obstructive syndromes of the lower urinary tract, including benign prostatic hyperplasia (BPH), in lowering intraocular pressure, in the treatment of cardiac arrhythmia and erectile and sexual dysfunction, and in the treatment of lower urinary tract symptoms (LUTS) and neurogenic lower urinary tract dysfunction (NLUTD). Compounds (I) per se, pharmaceutical compositions containing compounds (I) and medical uses of compounds (I) are claimed.

公开(公告)号：EP1315747A2

公开(公告)日：2003-06-04

申请号：EP01980332.9

申请日：2001-09-03

申请人： Cellpep S.A.

发明人： SABATIER, Jean-Marc ,  MABROUK, Kamel ,  ROCHAT, Hervé

IPC分类号： C07K14/435 ,  A61K38/17 ,  A01N63/02

CPC分类号： C07K14/43522 ,  A61K38/00

摘要： Derivatives of Maurotoxin (MTX) in which the native disulfide bridge pattern (Cys3-Cys24, Cys9-Cys29, Cys19, Cys31-Cys34) has been disrupted are useful for the treatment of pathologies associated with dysfunctioning and/or activation of Ca2+-activated and/or voltage-gated K+ channel subtypes, such as IKCa1 or Kv1.2. One preferred group of derivatives is that in which one or more of the Cys residues have been replaced with ?-aminobutyrate (Abu) residues, thus breaking one or more of the four disulphide bridges. Within this group, the preferred derivative is that in which the Cys residues at position 9, 19, 29 and 34 have been replaced with a ?-aminobutyrate residues. However, the derivative in which the Cys residues at positions 19 and 34 have been replaced with (Abu) residues is excluded Another preferred group of derivatives is that in which one or two of the amino acidresidues of maurotoxin have been replaced by different amino acid residues resulting in the disulfide bridge pattern being changed to Cys3-Cys24, Cys9-Cys29, Cys13-Cys31, Cys19-Cys34. Within this group, the preferred compounds are that which the Arg residue at position 14 has been replaced by a Gln residue, that in which the Lys residue at position 15 has been replaced by a Gln residue, that in which the Arg residue at position 14 and Lys residue at position 15 have both been replaced by Gln residues, those in which neither of the residues at positions 32 and 33 is a Gly or Pro residue, and that in which the Gly residue at position 33 has been replaced by an Ala residue. Pi1 and HsTx1 derivatives with disrupted native disulfide bridge patterns are similarly useful.