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公开(公告)号：EP2111262A2
公开(公告)日：2009-10-28
申请号：EP08705171.0
申请日：2008-01-10
IPC分类号： A61P9/04 , A61P9/06 , A61P9/10 , A61P25/06 , A61P25/22 , A61K31/4164 , A61K31/4178 , A61K45/06
CPC分类号： A61K31/4178 , A61K31/4164 , A61K45/06
摘要： Use of a compound of formula I, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl or alkylaryl group; X signifies CH2, oxygen atom or sulphur atom; n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2; and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof; wherein the term alkyl means hydrocarbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term aryl means a phenyl or naphthyl group, optionally substituted by alkyloxy, halogen or nitro group; the term halogen means fluorine, chlorine, bromine or iodine, in the manufacture of a medicament for the treatment of one or more of the following indications congestive heart failure, angina, arrhythmias, circulatory disorders such as Raynaud's Phenomenon, migraine, and anxiety disorders.
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72.发明公开USE OF 5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE DERIVATIVES IN THE TREATMENT OF NEUROPATHIC PAIN AND NEUROLOGICAL DISORDERS 审中-公开USE -5H-二苯并/ B，IN疼痛和神经疾病神经病理性于治疗F /氮杂-5-甲酰胺衍生物的
公开(公告)号：EP2004195A1
公开(公告)日：2008-12-24
申请号：EP07709273.2
申请日：2007-02-14
摘要： This invention relates to the use of 5H-dibenz/b,f/azepine-5-carboxamide derivatives in the manufacture of various medicaments for treating neuropathic pain and for treating neurological disorders which involve both motor impairment and neuropathic pain.
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73.发明公开
公开(公告)号：EP3604299A1
公开(公告)日：2020-02-05
申请号：EP19194756.3
申请日：2012-12-12
发明人： RUSSO, Domenico , KISS, Laszlo Erno , WAHNON, Jorge Bruno Reis , LEARMONTH, David Alexander , ESZENYI, Tibor , ZIMMERMANN, Axel , SCHLUMMER, Bjoern , KREIS, Michael , RIETER, Klaus
IPC分类号： C07D413/04
摘要： There is disclosed a methylated intermediate of formula (I) which may be demethylated to provide an inhibitor of catechol-O-methyltransferase useful in the treatment of Parkinson's disease. Also disclosed are methods of making and using said intermediate.
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公开(公告)号：EP2919780B1
公开(公告)日：2018-08-01
申请号：EP13803292.5
申请日：2013-11-14
IPC分类号： A61K31/417 , A61K31/4178 , A61K45/06 , A61P9/10 , A61P11/00
CPC分类号： C07D405/04 , A61K31/417 , A61K31/4178
摘要： The present invention relates to compounds of formula I: for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl, -alkylaryl or -alkylheteroaryl; X signifies CH2, oxygen atom or sulphur atom; n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2; and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof.
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公开(公告)号：EP2606035B1
公开(公告)日：2017-09-06
申请号：EP11749010.2
申请日：2011-07-28
IPC分类号： C07D233/90 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/12 , C07D405/14
CPC分类号： C07D233/90 , C07D233/60 , C07D233/61 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12
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公开(公告)号：EP1907382B1
公开(公告)日：2015-05-27
申请号：EP06769520.5
申请日：2006-07-26
发明人： LEARMONTH, David Alexander , KISS, Laszlo Erno , LEAL PALMA, Pedro Nuno , DOS SANTOS FERREIRA, Humberto , ARAÚJO SOARES DA SILVA, Patrício Manuel Vieira
IPC分类号： C07D413/04 , C07D413/14 , A61K31/421 , A61K31/4425 , A61K31/4439 , A61K31/506 , A61P25/00 , C07D417/14 , C07D413/06 , C07D401/04 , C07D213/89 , C07D407/04 , C07D271/06 , C07D271/10
CPC分类号： C07D413/14 , A61K31/4412 , C07D213/89 , C07D215/60 , C07D271/06 , C07D271/107 , C07D401/04 , C07D405/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04
摘要： New compounds of formula I are described: The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
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公开(公告)号：EP2726454A2
公开(公告)日：2014-05-07
申请号：EP12738246.3
申请日：2012-06-29
发明人： BELIAEV, Alexander , WAHNON, Jorge Bruno Reis , LEARMONTH, David Alexander , MADEC, Jonathan , SCHNEIDER, Jean-Marie , MATON, William
IPC分类号： C07C311/19 , C07D403/04
CPC分类号： C07D405/04 , C07C235/80 , C07C311/16 , C07C311/17
摘要： The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se.
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公开(公告)号：EP2297042B1
公开(公告)日：2013-07-10
申请号：EP09721339.1
申请日：2009-03-17
IPC分类号： C01G55/00 , C07D233/84 , C07D311/74 , C07D335/06 , C07D407/04 , C07D409/04
CPC分类号： C07D311/04 , C07D405/04 , C07F15/0053 , C07F15/008
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公开(公告)号：EP2475357A1
公开(公告)日：2012-07-18
申请号：EP10757859.3
申请日：2010-09-10
发明人： VASCONCELOS, Teófilo Cardoso de , SANTOS LIMA, Ricardo Jorge dos , CAMPOS COSTA, Rui Cerdeira de , COSTA BARROCAS, Pedro Miguel da , CASTRO PEREIRA, Lígia Sofia de
摘要： An oral suspension formulation comprising eslicarbazepine acetate and a pharmaceutically acceptable liquid vehicle.
摘要翻译： 一种口服悬浮液制剂，其包含乙酸西酞西泮和药学上可接受的液体载体。
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