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公开(公告)号：EP4352102A1
公开(公告)日：2024-04-17
申请号：EP22740661.8
申请日：2022-06-07
申请人： Kite Pharma, Inc.
IPC分类号： C07K16/28 , A61P35/00 , C07K16/30 , G01N33/574 , A61K39/00
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公开(公告)号：EP4435007A2
公开(公告)日：2024-09-25
申请号：EP24177635.0
申请日：2018-10-12
IPC分类号： C07K16/28
CPC分类号： A61P35/00 , A61K2039/50520130101 , C07K16/18 , C07K16/2809 , C07K16/2878 , C07K2317/2120130101 , C07K2317/2420130101 , C07K2317/3120130101 , C07K2317/5620130101 , C07K2317/56520130101 , C07K2317/56920130101 , C07K2317/62220130101 , C07K2317/73220130101 , C07K2317/7620130101 , C07K2317/9220130101 , C07K2319/3020130101 , C07K2319/3120130101
摘要： Provided herein are B cell maturation agent (BCMA) targeting trispecific proteins comprising a domain binding to CD3, a half-life extension domain, and a domain binding to BCMA. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such BCMA targeting trispecific proteins. Also disclosed are methods of using the disclosed BCMA targeting trispecific proteins in the prevention, and/or treatment diseases, conditions and disorders.
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公开(公告)号：EP4434587A2
公开(公告)日：2024-09-25
申请号：EP24179053.4
申请日：2019-02-08
发明人： CHANG, Gregory, P. , CHEUNG, Ann, F. , GRINBERG, Asya , HANEY, William , LUNDE, Bradley.M , PRINZ, Bianka
IPC分类号： A61P35/00
CPC分类号： A61P35/00 , C07K16/2851 , C07K2317/2420130101 , C07K2317/3120130101 , C07K2317/3520130101 , C07K2317/62220130101 , C07K2317/6420130101 , C07K2317/7320130101 , C07K2317/7620130101 , C07K2317/9420130101 , C07K16/2803 , C07K16/32 , C07K2317/5220130101 , C07K2317/73220130101 , A61K38/00 , C07K14/7056 , C07K2317/7020130101 , C07K2317/56520130101 , C07K2317/9220130101
摘要： Antibody heavy chain variable domains that can be paired with antibody light chain variable domains to form an antigen-binding site targeting the NKG2D receptor on natural killer cells are described. Proteins comprising an NKG2D antigen-binding site, pharmaceutical compositions and therapeutic methods thereof, including for the treatment of cancer, are also described.
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公开(公告)号：EP4430081A1
公开(公告)日：2024-09-18
申请号：EP22893797.5
申请日：2022-11-09
申请人： Wugen, Inc.
发明人： KABAKIBI, Ayman , SULLIVAN, Ryan P.
IPC分类号： C07K16/28 , G01N33/574 , C07K16/30
CPC分类号： C07K16/2827 , C07K16/2863 , C07K2317/7620130101 , C07K2317/2120130101 , C07K2317/2420130101 , C07K2317/73220130101 , A61K39/4613 , C07K16/32 , A61P35/00
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公开(公告)号：EP3913001B1
公开(公告)日：2024-09-11
申请号：EP19910759.0
申请日：2019-12-06
IPC分类号： C07K16/30 , C07K16/28 , C07K19/00 , C07K16/46 , C12N15/13 , C12N15/62 , C12N5/10 , A61K39/395 , A61K47/42 , A61K35/17 , A61P35/00
CPC分类号： A61P35/00 , C07K16/28 , C12N15/62 , C07K2317/56920130101 , C07K2317/9220130101 , C07K2317/2420130101 , C07K2317/73420130101 , C07K2317/73220130101 , A61K2039/50520130101 , C07K2317/3120130101 , C07K16/2809 , C07K14/7051 , C07K2319/0320130101 , C07K2319/3320130101 , A61K9/2004 , A61K9/0019 , A61K9/19 , C07K14/705 , A61K47/68 , C12N5/0636 , C12N2510/0020130101 , Y02A50/30 , A61K2239/3820230501 , A61K39/4611 , A61K39/464402 , A61K2239/5120230501 , A61K2239/3120230501 , A61K39/4631
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公开(公告)号：EP3612567B1
公开(公告)日：2024-09-11
申请号：EP18788508.2
申请日：2018-04-19
IPC分类号： C07K16/28 , A61K51/10 , A61K31/7068 , A61K39/395 , A61K45/06 , A61K47/68 , A61K39/00
CPC分类号： A61K31/7068 , A61K47/6849 , A61K45/06 , A61K39/3955 , C07K16/2818 , C07K16/2827 , A61K2039/50520130101 , A61K2039/50720130101 , C07K2317/2120130101 , C07K2317/2420130101 , C07K2317/3320130101 , C07K2317/7320130101 , C07K2317/73220130101 , C07K2317/7620130101 , C07K2317/9220130101 , A61K47/68031
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公开(公告)号：EP4424707A2
公开(公告)日：2024-09-04
申请号：EP24188725.6
申请日：2017-09-19
申请人： Tillotts Pharma AG
IPC分类号： C07K16/24
CPC分类号： C07K16/241 , C07K2317/4120130101 , C07K2317/7220130101 , C07K2317/7320130101 , C07K2317/73220130101 , C07K2317/73420130101 , C07K2317/7420130101 , C07K2317/7720130101 , C07K2317/9220130101
摘要： The present invention relates to antibodies which bind to TNFα and exhibit modified FcRn-binding. The antibodies of the invention have good effector functions and/or pharmacokinetic properties.
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公开(公告)号：EP3638700B8
公开(公告)日：2024-09-04
申请号：EP18818346.1
申请日：2018-06-13
IPC分类号： C07K16/46 , C07K19/00 , C12N15/13 , A61K39/395 , A61P35/00
CPC分类号： A61P35/00 , C07K14/5428 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K2319/0020130101 , C07K2319/7020130101 , C07K16/00 , C07K16/2863 , C07K16/303 , C07K16/3092 , C07K16/32 , C07K16/40 , A61K2039/50520130101 , C07K2317/2220130101 , C07K2317/52620130101 , C07K2317/56920130101 , C07K2317/62220130101 , C07K2317/6420130101 , C07K2317/73220130101 , C07K2317/9220130101 , C07K2319/3020130101
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公开(公告)号：EP4416187A1
公开(公告)日：2024-08-21
申请号：EP22880441.5
申请日：2022-10-17
发明人： YANG, Liu , SHEN, Hao , CUI, Feifei , FANG, Lei
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公开(公告)号：EP4413045A1
公开(公告)日：2024-08-14
申请号：EP22877943.5
申请日：2022-10-08
发明人： LI, Runsheng , HUANG, Wentao , LI, Yifan
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