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    Verfahren zur Herstellung von L-Carnitin aus D,L-Carnitinnitrilsalzen
    72.
    发明公开
    Verfahren zur Herstellung von L-Carnitin aus D,L-Carnitinnitrilsalzen 失效
    从D，L-三烯酸钠盐制备L-卡尼汀的方法

    公开(公告)号：EP0508133A3

    公开(公告)日：1993-03-03

    申请号：EP92104160.4

    申请日：1992-03-11

    申请人： DEGUSSA AG

    发明人： Jakob, Harald, Dr. ,  Huthmacher, Klaus, Dr. ,  Klenk, Herbert, Dr.

    IPC分类号： C07C227/34 ,  C07C229/12

    CPC分类号： C07C227/34

    摘要： Die Herstellung von L-Carnitin durch Racematspaltung von D,L-Carnitinnitrilsalzen, insbesondere des D,L-Carnitnnitrilchlorids, unter Verwendung von optisch aktiven Spaltreagenzien, Trennung der Diastereomeren, Überführung des L-Carnitinnitril enthaltenden Diastereomeren in ein Salz einer optisch nicht aktiven Säure und Verseifung des L-Carnitinnitrilsalzes gelingt in hoher Ausbeute und mit hoher Enantiomerenreinheit, wenn N-Acetyl-L-prolin als Spaltreagens verwendet wird. Hierbei wird das (LL)-Diastereomere in kristalliner Form aus dem Diastereomerengemisch abgetrennt, und eine bisher übliche zweite fraktionierende Kristallisationsstufe wird vermieden.

    Fluorine-containing compounds
    74.
    发明公开
    Fluorine-containing compounds 失效
    荧光黄酮

    公开(公告)号：EP0473871A2

    公开(公告)日：1992-03-11

    申请号：EP91105058.1

    申请日：1991-03-28

    申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.

    发明人： Kai, Yoshiaki ,  Suzuki, Takashi

    IPC分类号： C07C69/34 ,  C07C69/593 ,  C07C69/708 ,  C07C235/12 ,  C07C229/12 ,  C07C69/76 ,  C07C323/22 ,  C07C235/08 ,  C08G65/32 ,  G11B5/72 ,  C07C323/52 ,  C08G65/00

    CPC分类号： G11B5/725 ,  C07C69/63 ,  C07C69/65 ,  C07C69/76 ,  C07C229/12 ,  C07C235/08 ,  C07C323/52 ,  C08G65/329

    摘要： A fluorine-containing compound represented by the general formula [I]:
    wherein R f is a fluoroalkyl ether end group having 5 to 50 carbon atoms, R 1 is an aliphatic alkyl end group or an aliphatic alkenyl end group, R 2 is an aliphatic alkylene group or an aliphatic polyalkylene oxide group which have no or one or more carbon atoms, each of R 3 and R 4 is an aliphatic alkylene group having no or one or more carbon atoms, X is a connecting group selected from the group consisting of
    (wherein R 5 is an aliphatic alkylene group having no or one or more carbon atoms, and R 6 is a hydrogen atom or an aliphatic alkyl group having 1 to 12 carbon atoms), each of W and Y is connecting group selected from the group consisting of
    (wherein R 7 is a hydrogen atom or a methyl group), Z is a connecting group selected from the group consisting of
    and each of 1, m and n is zero or 1. There are disclosed a fluorine-containing compound of a specific structure which has in the molecule a fluoroalkyl ether end group, an aliphatic hydrocarbon end group and a carboxyl end group, and has a molecular weight of hundreds to about 3,000; and a process for producing the fluorine-containing compound. This fluorine-containing compound can be utilized in magnetic recording media in the form of a lubricant composition.

    摘要翻译： 由通式[I]表示的含氟化合物：其中，Rf是碳原子数5〜50的氟烷基醚端基，R1是脂肪族烷基端基或脂肪族烯基端基，R2是脂肪族 亚烷基或不具有一个或多个碳原子的脂族聚氧化烯基，R 3和R 4各自是不具有或一个或多个碳原子的脂族亚烷基，X是选自-COOR 5的连接基团 - 和-CON（R 6） - （其中R 5是没有或一个或多个碳原子的脂族亚烷基，R 6是氢原子或具有1至12个碳原子的脂肪族烷基），W和Y各自为 选自-S-，-COO-和-SCH2CH（R7）COO-（其中R7为氢原子或甲基）的连接基团，Z为选自下列的连接基团：CHEM> l，m和n分别为0或1.公开了一种特定的含氟化合物 在分子中具有氟烷基醚端基，脂族烃端基和羧基端基的分子结构，分子量为数百至约3,000; 和含氟化合物的制造方法。 该含氟化合物可用于润滑剂组合物形式的磁记录介质中。

    Process for the preparation of L-carnitine
    79.
    发明公开
    Process for the preparation of L-carnitine 失效
    一种用于生产L-肉碱过程。

    公开(公告)号：EP0210672A2

    公开(公告)日：1987-02-04

    申请号：EP86200864.6

    申请日：1986-05-20

    申请人： SCLAVO S.p.A.

    发明人： Casati, Paolo ,  Fuganti, Claudio

    IPC分类号： C07C209/12 ,  C07C209/08 ,  C07C229/12 ,  C07C227/22 ,  C07C229/22

    CPC分类号： C07C229/22

    摘要： A process is disclosed for the preparation of β-hydroxy-γ-trimethylamino-butyric acid (L-carnitine)
    wherein

    a) the compound diketene having formula:
    is reacted with chlorine, and the chlorination product thus obtained is submitted to amidation by the methylester of an optically-active aminoacid, having formula:
    wherein R = CH 2 A r or A r is a substitued or not- substituted aromatic group, to yield the compound 4-chloro-3-ketobutyrylamide of the methylester of the optically-active aminoacid:
    wherein R has the above reported meaning, b) the compound (IV) is reduced in the presence of a reducing agent to yield the compound
    wherein R has the above reported meaning, in the form of a mixture of (3R)-4-chloro-3-hydrox- ybutyrylamide of the methylester of an optically-active acid (VI), and (3S)-4-chloro-3-hydrox- ybutyrylamide of the methylester of an optically active aminoacid (VII),
    c) the compound (3R)-4-chloro-3-hydrox- ybutyrylamide of the methylester of an optically-active aminoacid (VI) is separated and recovered from the reduction reaction product,
    d) the compound (VI) is submitted to methanolysis by hydrogen chloride gas in methanol,
    e) the methylester of the optically-active aminoacid (III) is precipitated and recovered from the methanolysis reaction product,
    f) from the mother liquors the compound methylester of (3R)-4-chloro-3-hydroxybutyric acid having formula
    is recovered,
    g) the compound (VIII) thus obtained is treated with trimethylamine in ethanol, is hydrolyzed with hydro chloric acid and the compound L-carnitine (I) is separated and recovered.