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632 条记录 (耗时 0.028 秒)

    Polypeptide
    87.
    发明公开
    Polypeptide 失效
    Polypeptid。

    公开(公告)号：EP0477791A2

    公开(公告)日：1992-04-01

    申请号：EP91116017.4

    申请日：1991-09-20

    申请人： ISHIHARA SANGYO KAISHA, LTD.

    发明人： Yamada, Nobutoshi, Ishihara Sangyo Kaisha Ltd. ,  Kato, Masanari, Ishihara Sangyo Kaisha Ltd. ,  Miyata, Keizo, Ishihara Sangyo Kaisha Ltd. ,  Aoyama, Yoshiyuki, Ishihara Sangyo Kaisha Ltd. ,  Shikama, Hiroshi, Ishihara Sangyo Kaisha Ltd.

    IPC分类号： C07K14/00 ,  C12N15/28 ,  C12N1/21 ,  C12P21/02 ,  A61K38/00

    CPC分类号： C07K14/525 ,  A61K38/00

    摘要： A polypeptide which is a tumor necrosis factor polypeptide having an amino acid sequence represented by from the 1st Ser to the 155th Leu as shown by SEQ ID NO:1 in the Sequence Listing, or its mutein, wherein the amino acid sequence of the 1st Ser to the 8th Asp of the SEQ ID NO:1 or the corresponding amino acid sequence of the mutein is replaced by an amino acid sequence containing at least one amino acid sequence of Arg-Gly-Asp and from 3 to 16 amino acids. Also disclosed are a recombinant plasmid containing a DNA encoding such a polypeptide, a recombinant microbial cell transformed by such a recombinant plasmid, a process for producing the polypeptide, a pharmaceutical composition comprising the polypeptide as an active ingredient, and a DNA for the polypeptide.

    摘要翻译： 作为序列表中SEQ ID NO：1所示的具有由第1至第155位的Leu所表示的氨基酸序列的肿瘤坏死因子多肽的多肽或其突变蛋白，其中，第1序列的氨基酸序列 至SEQ ID NO：1的第8位Asp或突变蛋白的相应氨基酸序列被含有至少一个Arg-Gly-Asp氨基酸序列和3至16个氨基酸的氨基酸序列替代。 还公开了含有编码这种多肽的DNA，由这样的重组质粒转化的重组微生物细胞，产生多肽的方法，包含该多肽作为活性成分的药物组合物和该多肽的DNA的重组质粒。

    Imidazolidine derivatives, process for producing the same and pesticides containing the same
    90.
    发明公开
    Imidazolidine derivatives, process for producing the same and pesticides containing the same 失效
    咪唑啉衍生物，Verfahren zu deren Herstellung und diese enthaltendeSchädlingsbekämpfungsmittel。

    公开(公告)号：EP0437784A1

    公开(公告)日：1991-07-24

    申请号：EP90124821.1

    申请日：1990-12-19

    申请人： ISHIHARA SANGYO KAISHA, LTD.

    发明人： Haga, Takahiro, Ishihara Sangyo Kaisha Ltd. ,  Toki, Tadaaki, Ishihara Sangyo Kaisha Ltd. ,  Koyanagi, Toru, Ishihara Sangyo Kaisha Ltd. ,  Omatsu, Masato, Ishihara Sangyo Kaisha Ltd. ,  Sasaki, Hiroshi, Ishihara Sangyo Kaisha Ltd. ,  Morita, Masayuki, Ishihara Sangyo Kaisha Ltd. ,  Yoshida, Kiyomitsu, Ishihara Sangyo Kaisha Ltd.

    IPC分类号： C07D401/06 ,  A01N43/50 ,  C07D417/06 ,  C07D401/14 ,  A01N43/40 ,  A01N43/78

    CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D417/06

    摘要： An imidazolidine derivative having the formula (I) or its salt:

    wherein X is an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, a
    group (in which each of R¹, R², R³ and R⁴ is independently a hydrogen atom or an alkyl group, R⁵ is an alkyl group which may be substituted with a halogen atom, a cycloalkyl group which may be substituted or a phenyl group which may be substituted, W is an oxygen atom or a sulfur atom, and each of k, ℓ, m and n is independently 0 or 1, provided that (a) case where all of k, ℓ and m are 0 at the same time and (b) case where m and n are 0 at the same time and R⁵ is an alkyl group which may be substituted with a halogen atom, are excluded), or a
    group (in which each of R⁶ and R⁷ is independently a hydrogen atom or an alkyl group, each of R⁸ and R⁹ is independently an alkyl group, R¹⁰ is an alkyl group which may be substituted, an aryl group which may be substituted, a pyridyl group which may be substituted, an alkenyl group which may be substituted with a halogen atom or an alkynyl group which may be substituted with a halogen atom); Y is a 6-chloro-3-pyridyl group or a 2-chloro-5-thiazolyl group; Z is a hydrogen atom, an alkyl group or an acyl group; and j is an integer of from 0 to 2.

    摘要翻译： 具有式（I）的咪唑烷衍生物或其盐：其中X是可被取代的烷基，可被取代的烯基，可被取代的炔基，基团（在 其中R 1，R 2，R 3和R 4各自独立地为氢原子或烷基，R 5为可被卤素原子取代的烷基， 可以被取代的环烷基或可被取代的苯基，W是氧原子或硫原子，k，l，m和n各自独立地为0或1，条件是（a）全部 k，l和m同时为0，（b）m和n同时为0，R 5为可被卤素原子取代的烷基的情况除外），或 独立地为氢原子或烷基，R 8和R 9各自独立地为烷基，R 1为可被取代的烷基，芳基为 可以被取代，吡啶基 可被取代的取代基，可以被卤素原子取代的烯基或可被卤原子取代的炔基）; Y是6-氯-3-吡啶基或2-氯-5-噻唑基; Z是氢原子，烷基或酰基; j为0〜2的整数。