利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

746 条记录 (耗时 0.023 秒)

    1,2-Di-substituted piperidine derivatives as hair growth promoter
    85.
    发明公开
    1,2-Di-substituted piperidine derivatives as hair growth promoter 有权
    1,2-Disubstituierte Piperidinderivative verwendbar als Haarwuchsmittel

    公开(公告)号：EP0933361A1

    公开(公告)日：1999-08-04

    申请号：EP99101601.5

    申请日：1999-02-02

    申请人： SHISEIDO COMPANY LIMITED

    发明人： Kobayashi, Koji, Shiseido Research Center ,  Fukunishi, Hirotada, Shiseido Research Center ,  Umishio, Kenichi, Shiseido Research Center ,  Ishino, Akihiro, Shiseido Research Center

    IPC分类号： C07D211/22 ,  C07D211/26 ,  C07D401/12 ,  C07D521/00 ,  A61K7/06

    CPC分类号： C07D231/12 ,  C07D211/22 ,  C07D211/26 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12

    摘要： A 1,2-di-substituted piperidine derivative or a salt thereof expressed by the following Formula (I):
    wherein one of A and B is a hydrocarbon group of C 1-30 expressed by R 1 and the other is -(CH 2 )n-NR 2 R 3 ; Y is -CO-, -CONR 5 - or -COO-; Z is -O-, -OCO-, -OCONR 6 - or -NR 6 -; R 2 and R 3 individually represent a hydrogen a lower alkyl, a phenyl or a benzyl group, or together represent a heterocycle having 3-7 members; -NR 5 -(CH 2 )n-NR 2 R 3 and -NR 6 -(CH 2 )n-NR 2 R 3 of -(Y) 1 -A and -Z-B may be the following Group W:
    wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R 2 is a hydrogen, a lower alkyl, a phenyl or a benzyl group; R 4 is a hydrogen, a halogen, a lower alkyl, a lower acyl, a nitro, a cyano, a lower alkoxycarbonyl, a carbamoyl, a lower alkylcarbamoyl, a lower alkylamino, a lower acylamino, a lower alkoxy or a lower acyloxy group; each of R 5 and R 6 is a hydrogen, a lower alkyl, a lower acyl, a lower alkylcarbamoyl group, or a part of said ring E; l is 0 or 1; m is an integer of 2-5; and n is an integer of 0-5. The 1,2-di-substituted piperidine derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

    摘要翻译： 由下式（I）表示的1,2-二取代的哌啶衍生物或其盐：其中A和B之一是由R 1表示的C1-30的烃基，另一个是 - （CH 2）N-NR <2> [R <3>; Y是-CO - ， - CONR 5 - 或-COO-; Z是-O - ， - OCO - ， - OCONR 6 - 或-NR 6 - 。 R 2和R 3各自表示氢，低级烷基，苯基或苄基，或一起表示具有3-7个成员的杂环; - （Y）1-A和-ZB的-NR 5 - （CH 2）n -NR 2 R 3和-NR 6 - （CH 2）n -NR 2 R 3 可以是下列基团W：其中环E是包含两个氮原子的6或7个成员的杂环，R 2是氢，低级烷基，苯基或苄基; R 4是氢，卤素，低级烷基，低级酰基，硝基，氰基，低级烷氧基羰基，氨基甲酰基，低级烷基氨基甲酰基，低级烷基氨基，低级酰基氨基，低级烷氧基或低级 酰氧基 R 5和R 6各自为氢，低级烷基，低级酰基，低级烷基氨基甲酰基或所述环E的一部分; l为0或1; m为2-5的整数; n为0-5的整数。 1,2-二取代的哌啶衍生物或其盐具有优异的毛发生长和再生长促进作用，其可用于哺乳动物，特别是人的护发，改善或预防脱发。

    COPOLYMER CONTAINING REACTIVE SILYL GROUPS, COMPOSITION CONTAINING THE SAME, AND METHOD OF TREATMENT WITH THE SAME
    89.
    发明公开
    COPOLYMER CONTAINING REACTIVE SILYL GROUPS, COMPOSITION CONTAINING THE SAME, AND METHOD OF TREATMENT WITH THE SAME 失效
    成分含有共聚物反应性硅基HAVING AND METHOD FOR USE

    公开(公告)号：EP0918069A1

    公开(公告)日：1999-05-26

    申请号：EP98923063.6

    申请日：1998-06-01

    申请人： SHISEIDO COMPANY LIMITED

    发明人： MIYAZAWA, Kazuyuki Shiseido Research Center (1) ,  YANAKI, Toshio ,  MATSUZAKI, Fumiaki

    IPC分类号： C08L43/04 ,  C08L83/07 ,  C08L33/06 ,  C08L33/14 ,  C08F30/08 ,  C08F20/10 ,  C08F20/34 ,  C08F290/06 ,  C08G77/20 ,  A61K7/00 ,  A61K7/48 ,  C09K3/18 ,  D06M15/643 ,  D06M13/513

    CPC分类号： A61K8/895 ,  A61Q1/10 ,  A61Q3/02 ,  A61Q5/06 ,  A61Q5/10 ,  A61Q17/00 ,  C08F230/08 ,  C08F290/046 ,  C08F290/06 ,  C08F290/068 ,  C09K3/18 ,  D06M15/263 ,  D06M15/3568 ,  D06M15/643 ,  D06M2200/10 ,  D06M2200/12 ,  D06M2200/20 ,  D06M2200/40

    摘要： A composition of the present invention comprises a copolymer having silyl groups at least one reactive functional group bonded thereto. The copolymer preferably comprises, as one of constitutive monomers, Monomer (A) shown by the following Formula (I):
    wherein R 1 is hydrogen atom or methyl; R 2 alkylene group having 1-6 carbon atoms; and R 3 , R 4 and R 5 each is a reactive functional group which can cross-link molecules of the copolymer by hydrolyzing. Further, the copolymer preferably comprises, as a constitutive monomer, an alkyl (meth)acrylate and a siloxane-containing (meth)acrylate.
    The coat-forming method of the present invention comprises hydrolyzing the composition on a material to be treated to cross-link molecules of the copolymer,thereby forming a coat of the cross-linked copolymer having excellent resistance to washing. This coat can exhibit hair nature modifying effect, make-up retention improving effect, and skin-protecting effect. Also, it can impart water-repellency, unsusceptibility to fouling, suitability for sizing and crease resistance to fibers. Further, it can improve skin-cleaning effect, applicability, strippability and coat-strength of a peeling-off type cosmetic pack.

    摘要翻译： 本发明的组合物包含具有硅烷基键合其上的至少一个反应性官能团的共聚物。 优选包含作为构成单体之一，单体（A）由下式（I）中所示的共聚物：worin R1 是氢原子或甲基; 具有1-6个碳原子R 2亚烷基; 且R3，R4和R5各自是可通过水解交联共聚物的分子的反应性官能团。 此外，该共聚物优选包含，作为构成单体，烷基（甲基）和含硅氧烷的（甲基）丙烯酸酯的丙烯酸酯。 本发明的覆膜形成方法包括水解上的材料的组合物待治疗的共聚物的交联分子，由此形成具有洗涤性优异的交联的共聚物的涂层。 这件大衣可以呈现发质矫正效果，化妆保持改善效果，保护皮肤的作用。 因此，它可以赋予防水性，不易产生结垢，对于大小和抗皱性，以纤维的适宜性。 此外，它可以改善皮肤清洁效果，适用性，可剥性和剥离型面膜化妆料中的涂层强度。

    COMPOSITION FOR EXTERNAL USE FOR PREVENTION OF ENVIRONMENTAL STRESS
    90.
    发明公开
    COMPOSITION FOR EXTERNAL USE FOR PREVENTION OF ENVIRONMENTAL STRESS 失效
    ZUSAMMENSETZUNG ZUMÄUSSERLICHENGEBRAUCH ZUR VERHINDERUNG VON UMWELTSTRESS

    公开(公告)号：EP0914815A1

    公开(公告)日：1999-05-12

    申请号：EP98911080.4

    申请日：1998-03-30

    申请人： SHISEIDO COMPANY LIMITED

    发明人： EGAWA, Mariko, Shiseido Research Center (1), ,  SAKAMOTO, Tetsuo, Shiseido Research Center (1), ,  KOHNO, Yoshiyuki, Shiseido Research Center (1),

    IPC分类号： A61K7/00 ,  A61K7/48 ,  A61K31/195 ,  A61K31/235 ,  A61K31/375

    CPC分类号： A61K8/466 ,  A61K8/46 ,  A61K8/64 ,  A61K8/678 ,  A61K8/97 ,  A61Q1/02 ,  A61Q19/00

    摘要： A composition for improving environmental stress which contains one or more types of ingredients chosen from among a group consisting of sulfur containing amino acids, metabolic intermediates of sulfur containing amino acids, tannin and vitamin C and its derivatives. Also, said composition for improving environmental stress wherein said sulfur containing amino acid is glutathione and the metabolic intermediate of the sulfur containing amino acid is thiotaurine or hypotaurine. Also, said composition for improving environmental stress wherein hydroxycarboxylic acid or its derivative is additionally added to this composition. The liniment composition for preventing environmental stress pertaining to the present invention is suitable for eliminating the stress which has adverse effects on the skin among types of stress due to floating fine particles which float in the air.

    摘要翻译： 一种用于改善环境应力的组合物，其含有选自含硫氨基酸，含硫氨基酸的代谢中间体，单宁和维生素C及其衍生物的一种或多种成分。 此外，所述用于改善环境压力的组合物，其中所述含硫氨基酸是谷胱甘肽，并且含硫氨基酸的代谢中间体是硫代牛磺酸或牛磺酸。 而且，用于改善环境应力的组合物，其中另外向该组合物中加入羟基羧酸或其衍生物。 用于防止本发明的环境应力的搽剂组合物适用于消除由于漂浮在空气中的漂浮微粒引起的应力类型对皮肤有不利影响的应力。