公开(公告)号：EP1185645A1

公开(公告)日：2002-03-13

申请号：EP00936252.6

申请日：2000-05-23

申请人： ZymoGenetics, Inc.

发明人： PIDDINGTON, Christopher, S. ,  SHEPPARD, Paul, O.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12N15/62 ,  C12N5/10 ,  A61K38/17 ,  G01N33/68 ,  C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention relates to polynucleotide and polypeptide molecules for zacrp7, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. The polypeptides and polynucleotides encoding them, are involved in homo and heterotrimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp7 polypeptides.

公开(公告)号：EP1141296A2

公开(公告)日：2001-10-10

申请号：EP99969444.1

申请日：1999-09-16

申请人： ZymoGenetics, Inc.

发明人： CONKLIN, Darrell, C. ,  GRANT, Francis, J. ,  RIXON, Mark ,  KINDSVOGEL, Wayne

IPC分类号： C12N15/20 ,  C07K14/555 ,  C12N15/62 ,  C07K16/24 ,  A61K38/21 ,  C12Q1/68 ,  C12N7/01 ,  A61K31/70 ,  C12N5/10 ,  A61K48/00

CPC分类号： C07K14/555 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/021

摘要： Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. To date, four types of interferons have been found in humans: interferon-α, interferon-β, interferon-η, and interferon-φ. The present invention provides new forms of human and murine interferon, 'interferon-ε', which have applications in diagnosis and therapy.

公开(公告)号：EP1117793A2

公开(公告)日：2001-07-25

申请号：EP99953037.1

申请日：1999-10-01

申请人： ZymoGenetics, Inc.

发明人： LOK, Si ,  SHEPPARD, Paul, O.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  A61K38/17

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00

摘要： Secretory Protein - 48 (Zsig48), polypeptides, polynucleotides encoding said polypeptides, antibodies which specifically bind to Zsig48 and anti-idiotypic antibodies. Zsig48 polypeptides cause leukocytes to proliferate and thus can be used to elevate leukocytes in cancer treatments and in immunosuppressed patients.

公开(公告)号：EP0577605B1

公开(公告)日：2001-07-25

申请号：EP92902633.4

申请日：1991-12-12

申请人： ZYMOGENETICS, INC. ,  BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGTON

发明人： MULVIHILL, Eileen, Ranae ,  HAGEN, Frederick, Stamner ,  HOUAMED, Khaled, M. ,  ALMERS, Wolfhard

IPC分类号： C12N15/12 ,  C07K14/00 ,  C12P21/08 ,  A61K33/14 ,  G01N33/68

CPC分类号： C07K16/286 ,  C07K14/70571

公开(公告)号：EP1088068A1

公开(公告)日：2001-04-04

申请号：EP99925747.0

申请日：1999-05-20

申请人： ZymoGenetics, Inc.

发明人： SHEPPARD, Paul, O.

IPC分类号： C12N15/12 ,  C12N15/62 ,  C12N5/10 ,  C12N1/19 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/70503 ,  A01K2217/05 ,  C07K2319/00 ,  C12N2799/022 ,  C12N2799/026

摘要： The present invention relates to polynucleotide and polypeptide molecules for zsig57, a novel member of the immunoglobulin superfamily of proteins. The polynucleotides encoding zsig57, are located on chromosome 6, and may, for example, be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 本发明涉及用于zsig57的多核苷酸和多肽分子，其是蛋白质的免疫球蛋白超家族的新成员。 编码zsig57的多核苷酸位于染色体6上，并且可以例如用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：EP1032665A1

公开(公告)日：2000-09-06

申请号：EP98956578.3

申请日：1998-11-04

申请人： ZymoGenetics, Inc.

发明人： CONKLIN, Darrell, C. ,  BLUMBERG, Hal ,  DEISHER, Theresa, A.

IPC分类号： C12N15/12 ,  C12N15/62 ,  C07K14/47 ,  C12N5/10 ,  C07K16/18 ,  C12Q1/68

CPC分类号： C07K14/47 ,  C07K2319/02

摘要： The present invention relates to polynucleotide and polypeptide molecules for z219c, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting various human disease states and chromosomal abnormalities. The present invention also includes antibodies to the z219c polypeptides.

公开(公告)号：EP0973513A1

公开(公告)日：2000-01-26

申请号：EP97912787.5

申请日：1997-10-23

申请人： zymogenetics, Inc. ,  Osteoscreen, Inc. ,  University of Texas Austin

发明人： ORME, Mark, W. ,  BAINDUR, Nand ,  ROBBINS, Kirk, G. ,  HARRIS, Scott, M. ,  KONTOYIANNI, Maria ,  HURLEY, Laurence, H. ,  KERWIN, Sean, M. ,  MUNDY, Gregory, R. ,  PETRIE, Charles

IPC分类号： A61K31/165 ,  A61K31/215 ,  A61K31/33 ,  A61K31/405 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/53

CPC分类号： A61K31/655 ,  A61K31/196 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/53

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：EP0968288A1

公开(公告)日：2000-01-05

申请号：EP98953283.3

申请日：1998-10-06

申请人： ZymoGenetics, Inc.

发明人： CONKLIN, Darrell, C. ,  BLUMBERG, Hal

IPC分类号： C12N15/12 ,  C12N15/62 ,  C12N5/10 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  A01K67/027

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  C07K14/47 ,  C07K2319/02 ,  C12N2799/022 ,  C12N2799/026

摘要： The present invention relates to polynucleotide and polypeptide molecules for z219a, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities. The present invention also includes antibodies to the z219a polypeptides.

公开(公告)号：EP0968200A1

公开(公告)日：2000-01-05

申请号：EP98906624.6

申请日：1998-02-23

申请人： ZymoGenetics, Inc.

发明人： BAINDUR, Nand ,  LABROO, Virender ,  STROOP, Steven ,  BEIGEL, Stephanie ,  MARTINEZ, Theresa ,  PETRIE, Charles ,  ORME, Mark, W. ,  MCKERNAN, Patricia, A. ,  MOORE, Emma, E.

IPC分类号： C07D295/08 ,  C07D295/18 ,  A61K31/495

CPC分类号： C07D295/096 ,  A61K31/495 ,  C07D295/215

摘要： Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.

公开(公告)号：EP0931148A1

公开(公告)日：1999-07-28

申请号：EP97910128.0

申请日：1997-10-16

申请人： ZymoGenetics, Inc.

发明人： DEISHER, Theresa, A. ,  CONKLIN, Darrell, C. ,  RAYMOND, Fenella, C. ,  BUKOWSKI, Thomas, R. ,  HOLDERMAN, Susan, D. ,  HANSEN, Brigit ,  SHEPPARD, Paul, O.

IPC分类号： C12N15 ,  A61K38 ,  A61P9 ,  A61P19 ,  A61P21 ,  C07K14 ,  C07K16 ,  C07K19 ,  C12N1 ,  C12N5 ,  C12P21

CPC分类号： C12N5/0657 ,  A61K38/00 ,  A61K47/62 ,  A61K47/6835 ,  C07K14/50 ,  C07K16/22 ,  C07K2319/00 ,  C12N2501/119

摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5, a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.