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公开(公告)号：EP3118305B1
公开(公告)日：2019-08-14
申请号：EP14885605.7
申请日：2014-04-28
发明人： HUANG, Jun , WANG, Jidong , CHEN, Anliang , DENG, Aiwen , LIN, Jiatan , YU, Zhen , LI, Meihong , LI, Na , WANG, Haibin , ZHENG, Linghui , BAI, Hua
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公开(公告)号：EP3459952A1
公开(公告)日：2019-03-27
申请号：EP17798784.9
申请日：2017-05-19
发明人： CHEN, Lei , GUAN, Dongliang , BAI, Hua , GOU, Jun , ZHAO, Weifeng , WANG, Zhongli , LING, Long , MA, Yutao
IPC分类号： C07D471/10 , C07D403/12 , C07D487/10 , A61K31/506 , A61P35/00
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：EP3444253A1
公开(公告)日：2019-02-20
申请号：EP17781792.1
申请日：2017-03-28
发明人： ZHONG, Jinqing , ZHAO, Xuyang , BAI, Hua , GONG, Yongxiang , ZHANG, Xinlong , ZHU, Qifeng , LIU, Weiwei , ZHOU, Ya
IPC分类号： C07D491/056 , C07D491/113
摘要： Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.
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公开(公告)号：EP2835377B1
公开(公告)日：2018-12-05
申请号：EP13772541.2
申请日：2013-04-01
发明人： REN, Guobin , DAI, Changliang , CHEN, Jinyao , CHEN, Feng , QI, Minghui , ZHU, Wenming , HONG, Minghuang , BAI, Hua
IPC分类号： C07J17/00
CPC分类号： C07J17/005 , C07B2200/13
摘要： Provided are ginsenoside C-K polymorphic forms and a method for preparing same. The ginsenoside C-K polymorphic forms are crystal form D and crystal form H.
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公开(公告)号：EP3406619A1
公开(公告)日：2018-11-28
申请号：EP16885495.8
申请日：2016-01-18
发明人： YIN, Mingxing , WU, Dongdong , WEN, Weijiang
摘要： Disclosed are a method and an intermediate for preparing a tulathromycin. The method comprises the following step: in an organic solvent, subjecting a compound represented by formula (II) and an n-propylamine to a ring-opening addition shown below to obtain a tulathromycin represented by formula (I), wherein the organic solvent is a 1,2-propandiol. Tulathromycin obtained using the method has a high purity, with an HPLC purity being 95% and above, and up to 99% and above, satisfying a required purity for preparing a tulathromycin as a pharmaceutical formulation. The method has a high yield, is simple to operate, and is more suitable for industrial production.
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公开(公告)号：EP3378861A1
公开(公告)日：2018-09-26
申请号：EP16863515.9
申请日：2016-10-11
发明人： GUAN, Dongliang , SHENG, Shouyi , BAI, Hua
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61P35/00
摘要： The present invention relates to an acrylic acid derivative as shown in general formula (I), a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, the preparation method thereof, a pharmaceutical composition containing same, and the use thereof as therapeutic agents, in particular as selective estrogen receptor degraders (SERD), wherein the substituents of general formula (I) are the same as those defined in the description.
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87.发明公开
公开(公告)号：EP3339305A1
公开(公告)日：2018-06-27
申请号：EP16836680.5
申请日：2016-08-19
发明人： CHEN, Lei , GUAN, Dongliang , BAI, Hua , YAN, Xing , MIAO, Shuai , ZHU, Songsong
IPC分类号： C07D403/14 , A61K31/4184 , A61P35/00
CPC分类号： C07D403/14 , A61K31/4184 , A61P35/00 , C07D233/06 , C07D233/28 , C07D233/46 , C07D233/48 , C07D401/14
摘要： An indole derivative as expressed by Formula (I), a preparation method thereof, a pharmaceutical salt, and use thereof as a therapeutic agent, especially as a FGFR inhibitor. Each substituent in Formula (I) has identical definition as specified in the specification.
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公开(公告)号：EP3299381A1
公开(公告)日：2018-03-28
申请号：EP16901517.9
申请日：2016-11-09
发明人： WANG, Haibo , KUANG, Hongfu , ZHANG, Wei , CAI, Zhengjiang , ZHU, Tianmin , ZHENG, Xiaohe , WU, Zhongwei , YANG, Zhiqing
IPC分类号： C07K5/037 , A61K31/436 , A61P35/00 , A61P37/06
CPC分类号： C07K5/0215 , A61P35/00
摘要： Water-soluble glutathione modified rapamycin derivatives of formula I and the preparation method thereof, wherein R 1 and R 2 are as defined in the description. The compound of formula I can be used in inducing immunosuppression and in the treatment of diseases such as transplant rejection and solid tumor, etc.
摘要翻译： 式I的水溶性谷胱甘肽修饰的雷帕霉素衍生物及其制备方法，其中R1和R2如说明书中所定义。 式I化合物可用于诱导免疫抑制和治疗诸如移植排斥和实体瘤等疾病。
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公开(公告)号：EP3275996A1
公开(公告)日：2018-01-31
申请号：EP16771323.9
申请日：2016-03-25
发明人： TENG, Yun , XU, Meidong , MO, Meiyi , HE, Zhihui , CHEN, Zhengjie , JIANG, Lianqing , BAI, Hua
CPC分类号： C12N1/20 , C12P17/181 , C12R1/55
摘要： Provided are a Streptomyces (Streptomyces hygroscopicus) HS7523 and a method for preparing milbemycin A3 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7523 is deposited in "China General Microbiological Culture Collection Center" with an accession number of CGMCC No.9672 on September 16, 2014.
摘要翻译： 提供了链霉菌（Streptomyces hygroscopicus）HS7523和通过培养链霉菌来制备米尔倍霉素A3的方法。 链霉菌（Streptomyces hygroscopicus）HS7523于2014年9月16日保藏于“中国普通微生物菌种保藏中心”，保藏号为CGMCC No.9672。
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公开(公告)号：EP3275995A1
公开(公告)日：2018-01-31
申请号：EP16771322.1
申请日：2016-03-25
发明人： TENG, Yun , XU, Meidong , MO, Meiyi , HE, Zhihui , CHEN, Zhengjie , JIANG, Lianqing , BAI, Hua
摘要： Provided are a Streptomyces (Streptomyces hygroscopicus) HS7522 and a method for preparing milbemycin A4 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7522 of the present invention is deposited in "China General Microbiological Culture Collection Center" with an accession number of CGMCC No.9671 on September 16, 2014.
摘要翻译： 提供了链霉菌（Streptomyces hygroscopicus）HS7522和通过培养链霉菌来制备米尔倍霉素A4的方法。 本发明的链霉菌（吸水链霉菌）HS7522于2014年9月16日保藏于“中国普通微生物菌种保藏中心”，保藏号为CGMCC No.9671。
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