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公开(公告)号：EP3613842A1
公开(公告)日：2020-02-26
申请号：EP18768702.5
申请日：2018-03-13
发明人： HUANG, Jun , LI, Na , LIN, Jiatan , LI, Meihong , ZHOU, Jun , CHANG, Zongming
IPC分类号： C12N1/20 , C12P19/62 , A61K31/7048 , A61P33/14 , C12R1/465
摘要： Provided are a Streptomyces avermitilis strain C63-51 with a high yield of ivermectin B1b and a method for producing ivermectin B1b by using this strain. By using the above-mentioned strain and method, efficient production of single ivermectin B1b can be achieved.
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公开(公告)号：EP4361144A1
公开(公告)日：2024-05-01
申请号：EP22827556.6
申请日：2022-06-21
发明人： ZHAO, Meiyu , CHEN, Lianwei , LI, Na , SHI, Zhenjuan , ZHENG, Jianfeng , SU, Di
IPC分类号： C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00
CPC分类号： C07D403/12 , C07D471/10 , C07D487/10 , A61P35/00 , A61K31/506
摘要： The present invention relates to the field of chemical pharmacy, relates to a crystal form of a pyrimidine derivative and a preparation method therefor, and specifically relates to crystal forms A, B, C, D, and E of a compound of formula (I), a preparation method therefor, and a pharmaceutical composition and use thereof. The present invention solves the problems of small granularity, poor fluidity, poor stability and the like of the compound of formula (I) present in an amorphous form. The crystal form prepared by the present invention and the pharmaceutical composition thereof can be used for preparing a drug for treating a cancer disease.
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3.发明公开RECOMBINANT MICROORGANISM EXPRESSING AVERMECTIN ANALOGUE AND USE THEREOF 有权AVEMECTIN-ANALOGON EXPRIMIERENDER REKOMBINANTER MIKROORGANISMUS UND DAVON VERWENDUNG
公开(公告)号：EP3118305A1
公开(公告)日：2017-01-18
申请号：EP14885605.7
申请日：2014-04-28
发明人： HUANG, Jun , WANG, Jidong , CHEN, Anliang , DENG, Aiwen , LIN, Jiatan , YU, Zhen , LI, Meihong , LI, Na , WANG, Haibin , ZHENG, Linghui , BAI, Hua
CPC分类号： A01N43/90 , C12N15/76 , C12P19/623 , C12R1/465
摘要： The present invention relates to a recombinant microorganism expressing avermectin or analogues thereof and construction method thereof, and also relates to a method of producing avermectin or analogues thereof using the recombinant microorganism, and avermectin or analogues thereof obtained using the method. In addition, the present invention further relates to uses of the avermectin or analogues thereof as insecticides. Using the recombinant microorganism of the present invention to produce avermectin or analogues thereof has numerous advantages, for example comprising at least one of the following: good stability, high yield, simple process, environmentally friendly, and greatly saving of production costs.
摘要翻译： 本发明涉及表达除虫菌素或其类似物的重组微生物及其构建方法，还涉及使用该方法得到的重组微生物和除虫菌素或其类似物来生产除虫菌素或其类似物的方法。 此外，本发明还涉及除虫菌素或其类似物作为杀虫剂的用途。 使用本发明的重组微生物来生产除虫菌素或其类似物具有许多优点，例如包括以下至少一种：良好的稳定性，高产率，简单的工艺，环保且大大节省生产成本。
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公开(公告)号：EP3118206B1
公开(公告)日：2020-05-27
申请号：EP15762274.7
申请日：2015-03-10
发明人： HUANG, Jun , WANG, Jidong , ZHANG, Hui , WANG, Lingping , LI, Na , LI, Meihong , BAI, Hua , JIN, Minqi
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公开(公告)号：EP3118305B1
公开(公告)日：2019-08-14
申请号：EP14885605.7
申请日：2014-04-28
发明人： HUANG, Jun , WANG, Jidong , CHEN, Anliang , DENG, Aiwen , LIN, Jiatan , YU, Zhen , LI, Meihong , LI, Na , WANG, Haibin , ZHENG, Linghui , BAI, Hua
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6.发明公开SPINOSAD HETEROLOGOUS EXPRESSION STRAIN AND CONSTRUCTION METHOD THEREOF AND USE 审中-公开SPINOSAD异源表达菌株及其构建方法和应用
公开(公告)号：EP3219788A1
公开(公告)日：2017-09-20
申请号：EP14905979.2
申请日：2014-11-14
发明人： HUANG, Jun , YU, Zhen , LI, Meihong , ZHENG, Linghui , LI, Na , WANG, Haibin , BAI, Hua
摘要： The invention provides a construction method of spinosad heterologous expression strain, a spinosad heterologous expression strain obtained by the method and use thereof in preparing spinosad. The method utilizes a plurality of homologous recombination to replace the erythromycin synthetic gene cluster of Saccharopolyspora erythraea with the spinosad synthetic gene cluster and the rhamnose synthetic gene cluster, such that the Saccharopolyspora erythraea produces spinosad.
摘要翻译： 本发明提供了多杀菌素异源表达菌株的构建方法，由该方法获得的多杀菌素异源表达菌株及其在制备多杀菌素中的应用。 该方法利用多杀菌素同源重组，用多杀菌素合成基因簇和鼠李糖合成基因簇代替红色糖多孢菌红霉素合成基因簇，以使糖多孢菌红霉菌产生多杀菌素。
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7.发明公开SIXTEEN-MEMBERED MACROLIDE COMPOUND AND APPLICATIONS THEREOF 审中-公开MAKROLIDVERBINDUNG MIT 16-ELEMENTEN UND ANWENDUNGEN DAVON
公开(公告)号：EP3118206A1
公开(公告)日：2017-01-18
申请号：EP15762274.7
申请日：2015-03-10
发明人： HUANG, Jun , WANG, Jidong , ZHANG, Hui , WANG, Lingping , LI, Na , LI, Meihong , BAI, Hua , JIN, Minqi
摘要： A sixteen-membered macrolide compound and use thereof, the compound structure being represented in formula (I), wherein R is CH 3 or C 2 H 5 . The present compound has a wide range of application in the preparation of chemicals for preventing and controlling insect pests and mites of agriculture and forestry.
摘要翻译： 十六元大环内酯化合物及其用途，化合物结构如式（I）所示，其中R为CH 3或C 2 H 5。 本发明化合物在制备用于预防和控制农林害虫和螨虫的化学品中具有广泛的应用。
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