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公开(公告)号：EP1218408A4
公开(公告)日：2003-02-26
申请号：EP00965302
申请日：2000-09-22
发明人： NI JIAN , BAKER KEVIN P , BIRSE CHARLES E , EBNER REINHARD , FISCELLA MICHELE , KOMATSOULIS GEORGE A , LAFLEUR DAVID W , MOORE PAUL A , OLSEN HENRIK S , ROSEN CRAIG A , RUBEN STEVEN A , SOPPET DANIEL R , YOUNG PAUL E , WEI PING , FLORENCE KIMBERLY A
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/06 , A61P9/02 , A61P9/10 , A61P13/08 , A61P13/12 , A61P15/04 , A61P15/08 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/566 , C12N5/16 , C12N15/63 , C12N15/64
CPC分类号： C07K14/47
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公开(公告)号：EP1121419A4
公开(公告)日：2003-02-05
申请号：EP99952028
申请日：1999-10-19
发明人： NI JIAN , RUBEN STEVEN M
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P3/00 , A61P7/04 , A61P9/00 , A61P11/00 , A61P13/00 , A61P17/00 , A61P19/00 , A61P25/00 , A61P27/00 , A61P29/00 , A61P31/00 , A61P33/00 , A61P35/00 , A61P35/04 , A61P37/00 , A61P43/00 , C07K14/705 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/06 , C12Q1/68 , G01N33/15 , G01N33/68 , C07K14/47 , C07K14/52 , C07K14/525 , C12N15/12 , C12N15/19 , C12N15/28 , C12N15/63 , C12N15/64
CPC分类号： C07K14/70578 , A61K38/00
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公开(公告)号：EP1171579A4
公开(公告)日：2002-07-31
申请号：EP00914975
申请日：2000-03-16
发明人： NI JIAN , GENTZ REINER L , YU GUO-LIANG , FAN PING
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/16 , A61P9/10 , A61P11/04 , A61P17/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/12 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , C07K14/705 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , G01N33/15 , G01N33/53 , G01N33/564 , G01N33/566 , C07K14/47 , C07K14/71 , C07K16/24 , C12N15/63 , C12N15/64
CPC分类号： C07K14/70578 , C07K2319/00 , C07K2319/30 , C12N2799/026
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84.发明公开VEGI, AN INHIBITOR OF ANGIOGENESIS AND TUMOR GROWTH 有权VEGI，EIN INHIBITOR DER ANGIOGENESE UND DES TUMORWACHSTUMS
公开(公告)号：EP1042343A4
公开(公告)日：2001-08-16
申请号：EP98958456
申请日：1998-11-02
发明人： LI LU-YUAN , ZHAI YIFAN , YU GUO-LIANG , NI JIAN , LIPPMAN MARC E , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K48/00 , A61P9/10 , A61P17/02 , A61P17/06 , A61P27/02 , A61P27/06 , A61P35/00 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/705 , C12Q1/68 , C07H21/00 , A01N43/04 , A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026
摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
摘要翻译： 本发明涉及能够抑制动物模型中细胞模型中的血管生成和肿瘤发生的血管内皮细胞抑制剂VEGI及其使用方法。
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公开(公告)号：EP0828752A4
公开(公告)日：2000-07-26
申请号：EP97917674
申请日：1997-03-21
CPC分类号： C12Y302/01014 , C12N9/2442
摘要： Nucleic acid sequences for chitotriosidase are provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.
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公开(公告)号：EP1157110A4
公开(公告)日：2006-05-10
申请号：EP00908739
申请日：2000-02-22
发明人： ROSEN CRAIG A , NI JIAN , EBNER REINHARD , YU GUO-LIANG
IPC分类号： C12N15/09 , A61K38/00 , A61K38/19 , A61P31/00 , A61P35/04 , A61P37/02 , A61P37/04 , A61P37/06 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/19 , C12P21/02
CPC分类号： C07K14/715 , A61K38/00 , C07K14/52 , C07K16/24 , C07K2317/34
摘要： The present invention relates to a novel cytokine which has been designated Neutrokine-alpha ("Neutrokine-alpha"). In addition, an apparent splicing variant of Neutrokine-alpha has been identified and designated Neutrokine-alphaSV. In specific embodiments, the present invention provides nucleic acid molecules encoding Neutrokine-alpha and Neutrokine-alphaSV polypeptides. In additional embodiments, Neutrokine-alpha and Neutrokine-alphaSV polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译： 本发明涉及一种已被指定为中枢神经素α（“Neutrokine-α”）的新型细胞因子。 此外，已经鉴定了Neutrokine-α的明显剪接变体，并被指定为Neutrokine-αSV。 在具体实施方案中，本发明提供了编码中枢神经素α和中枢神经素αSV多肽的核酸分子。 在另外的实施方案中，还提供了中和性α和中枢神经素-αSV多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。
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公开(公告)号：EP1124850A4
公开(公告)日：2005-10-19
申请号：EP99972222
申请日：1999-10-27
发明人： NI JIAN , RUBEN STEVEN M , OLSEN HENRIK S , YOUNG PAUL E , KENNY JOSEPH J , MOORE PAUL A , WEI YING-FEI , GREENE JOHN M
IPC分类号： G01N33/53 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/395 , A61K48/00 , A61P3/10 , A61P7/00 , A61P7/06 , A61P9/10 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/18 , A61P33/02 , A61P33/04 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/19 , G01N33/566 , C07K14/435
CPC分类号： C12N9/6424 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546
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公开(公告)号：EP1317472A4
公开(公告)日：2005-04-27
申请号：EP01984565
申请日：2001-01-17
发明人： ROSEN CRAIG A , KOMATSOULIS GEORGE A , BAKER KEVIN P , BIRSE CHARLES E , SOPPET DANIEL R , OLSEN HENRIK S , MOORE PAUL A , WEI PING , EBNER REINHARD , DUAN ROXANNE D , SHI YANGGU , CHOI GIL H , FISCELLA MICHELE , NI JIAN
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N1/21 , C07H21/04 , C07H5/00 , C07H21/02 , C07K14/00 , C12N15/63 , C12N15/85 , C12N15/86 , C12Q1/68
CPC分类号： C07K14/70571 , A61K38/00 , C07K14/47 , C07K14/4713
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公开(公告)号：EP1317469A4
公开(公告)日：2005-01-12
申请号：EP01908620
申请日：2001-01-17
发明人： ROSEN CRAIG A , KOMATSOULIS GEORGE A , BAKER KEVIN P , BIRSE CHARLES E , SOPPET DANIEL R , OLSEN HENRIK S , MOORE PAUL A , WEI PING , EBNER REINHARD , DUAN D ROXANNE , SHI YANGGU , CHOI GIL H , FISCELLA MICHELE , NI JIAN
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N1/21 , C12Q1/68 , C07H21/04 , C07H21/02 , C07K5/00 , C07K14/00 , C07K14/435 , C12N15/36 , C12N15/85 , C12N15/86
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C12Q1/6886 , C12Q2600/136
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公开(公告)号：EP1237901A4
公开(公告)日：2005-01-12
申请号：EP00976756
申请日：2000-11-01
发明人： RUBEN STEVEN M , KOMATSOULIS GEORGE A , MOORE PAUL A , BIRSE CHARLES E , NI JIAN
IPC分类号： C12N15/09 , A61K31/7084 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , A61K31/713 , A61K38/17 , A61K39/395 , C12N15/12 , C12Q1/68 , G01N33/68
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