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1506 条记录 (耗时 0.041 秒)

    QUINOLYLBENZOFURAN DERIVATIVES AS LEUKOTRIENE ANTAGONISTS
    85.
    发明授权
    QUINOLYLBENZOFURAN DERIVATIVES AS LEUKOTRIENE ANTAGONISTS 失效
    枸橼酸胆碱

    公开(公告)号：EP0626956B1

    公开(公告)日：1997-05-07

    申请号：EP93904318.8

    申请日：1993-02-18

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： MATSUO, Masaaki ,  OKUMURA, Kazuo ,  SHIGENAGA, Shinji

    IPC分类号： C07D405/04 ,  A61K31/47 ,  C07D405/14

    CPC分类号： C07D405/04 ,  C07D405/14

    摘要： This invention relates to new quinolylbenzofuran derivatives having activities as leukotrien and Slow Reacting Substance of Anaphylaxis antagonists and inhibitors and represented by general formula (I), wherein R1 is halogen, etc., R2 is hydrogen or halogen, R3 is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy, R4 is hydrogen, acyl, cyano, nitro, substituted or unsubstituted aryl, or substituted or unsubstituted lower alkyl, R5 is hydrogen, hydroxy, lower alkyl or lower alkoxy, A is lower alkylene, lower alkenylene or a single bond, X is a single bond, O, NH, S, SO or SO¿2?, and Y is O or S, provided that when R?3¿ is hydrogen, R4 is hydrogen, R5 is hydrogen, A is a single bond and X is a single bond, then R1 is halogen, etc., and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.

    PROCESS FOR PRODUCING 2-KETO-L-GULONIC ACID
    86.
    发明公开
    PROCESS FOR PRODUCING 2-KETO-L-GULONIC ACID 失效
    VERFAHREN ZUR HERSTELLUNG VON 2-KETO-L-GULONSÄURE

    公开(公告)号：EP0758679A1

    公开(公告)日：1997-02-19

    申请号：EP95909983.9

    申请日：1995-02-24

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： NIWA, Mineo ,  SAITO, Yoshimasa ,  ISHII, Yoshinori ,  YOSHIDA, Masaru ,  HAYASHI, Hiromi

    IPC分类号： C12N9/04 ,  C12N15/53 ,  C12N1/19

    CPC分类号： C12N9/0008 ,  C12N9/0006 ,  C12P7/60 ,  Y10S435/822

    摘要： An expression vector containing both of a DNA coding for L-sorbose dehydrogenase and a DNA coding for L-sorbosone dehydrogenase; a transformant capable of producing 2-keto-L-gulonic acid (2KLGA) from D-sorbitol in a high yield and prepared by transforming with the above vector a microorganism which produces L-sorbose from D-sorbitol in a high yield and which has no or little activity of decomposing 2KLGA, or such a microorganism which has, in addition, no or little activity of producing L-idonic acid; and a process for producing 2KLGA by culturing the transformant in a medium containing D-sorbitol. The invention process enables 2KLGA useful for producing L-ascorbic acid to be produced readily in a large amount at a good efficiency by single culture.

    摘要翻译： 含有编码L-山梨糖脱氢酶的DNA和编码L-山梨糖酮脱氢酶的DNA的表达载体; 能够以高产率从D-山梨糖醇生产2-酮-L-古洛糖酸（2KLGA）的转化体，并通过用上述载体以高产率从D-山梨醇转化产生L-山梨糖的微生物制备， 没有或很少分解2KLGA的活性，或者这样的微生物，另外没有或很少生产L-吉非糖的活性; 以及通过在含有D-山梨醇的培养基中培养转化体来生产2KLGA的方法。 本发明方法使得2KLGA能够通过单一培养以高效率大量容易地生产L-抗坏血酸。