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89 条记录 (耗时 0.017 秒)

    Esculetin derivatives and method for manufacture thereof, use thereof, and pharmaceutical composition
    84.
    发明公开
    Esculetin derivatives and method for manufacture thereof, use thereof, and pharmaceutical composition 失效
    七叶亭衍生物及其制造方法，其用途和药物组合物

    公开(公告)号：EP0654479A3

    公开(公告)日：1995-09-13

    申请号：EP94118020.0

    申请日：1994-11-15

    申请人： KUREHA CHEMICAL INDUSTRY CO., LTD.

    发明人： Watanabe, Koju ,  Niimura, Koichi ,  Miyagawa, Junko

    IPC分类号： C07H17/075 ,  A61K31/70

    CPC分类号： C07H17/075 ,  Y02P20/55

    摘要： A compound of the formula (I):

    wherein R¹ and R² are, independently, a hydrogen atom, a monosaccharide residue, a protected monosaccharide residue, or a protecting group for hydroxyl group, but at least one of R¹ and R² is a monosaccharide residue or a protected monosaccharide residue, and R³ is a hydrogen atom, a hydroxyl group, an alkyl group, an aryl group, or an aralkyl group, with the proviso that (1) when R¹ and R² are glucose residues at the same time, R³ is not a hydrogen atom, (2) when R¹ is a hydrogen atom, an acetyl group or a benzyl group and R² is a glucose residue, an acetylated glucose residue, or acetalized glucose residue, R³ is not a hydrogen atom, or (3) when R¹ is a glucose residue and R² is a hydrogen atom, R³ is not a hydrogen atom or a salt thereof is disclosed.

    摘要翻译： 式（Ⅰ）化合物：其中R 1和R 2分别是氢原子，单糖残基，被保护的单糖残基或羟基保护基，但至少R 1和R 2之一是单糖残基 或被保护的单糖残基，R 3是氢原子，羟基，烷基，芳基或芳烷基，条件是（1）当R 1和R 2同时为葡萄糖残基时，R 3 （2）当R 1是氢原子，乙酰基或苄基，R 2是葡萄糖残基，乙酰化葡萄糖残基或缩醛葡萄糖残基时，R 3不是氢原子，或（3） ）当R 1是葡萄糖残基且R 2是氢原子时，R 3不是氢原子或其盐。

    Preparation of oligosaccharide derivatives
    86.
    发明公开
    Preparation of oligosaccharide derivatives 失效
    Herstellung von Oligosaccharidderivaten。

    公开(公告)号：EP0519683A1

    公开(公告)日：1992-12-23

    申请号：EP92305508.1

    申请日：1992-06-16

    申请人： GENZYME LIMITED (formerly known as Genzyme (UK) Ltd)

    发明人： Jackson, Christopher B. ,  Siddique, Farhat K. ,  Stevens, David R. ,  Moore, Stephen P.

    IPC分类号： C07H23/00 ,  C12Q1/40 ,  C07H15/203 ,  C07H3/06

    CPC分类号： C07H15/203 ,  C07H17/075 ,  C07H23/00 ,  C12Q1/40 ,  C12Q2334/10

    摘要： A process for the direct silylation of the terminal, non-reducing glucose unit of an oligosaccharide containing at least three repeating glucose units and having an aglycone unit at the reducing end thereof, the aglycone being selected from nitrophenyl, 2-chloro-4-nitrophenyl, 4-methylumbeliferone, luciferin and chromogenic phenols, which comprises:

    (a) forming a solution of the oligosaccharide in a solvent:
    (b) reacting the oligosaccharide with a silylating protective agent in the presence of a base; and
    (c) recovering a monosilylated oligosaccharide derivative from the reaction mixture is disclosed.

    摘要翻译： 一种用于直接甲硅烷基化终端的方法，含有至少三个重复葡萄糖单元的寡糖的非还原性葡萄糖单元，还原末端具有糖苷配基单元，所述糖苷配基选自硝基苯基，2-氯-4-硝基苯基 包括：（a）在溶剂中形成寡糖的溶液：（b）在碱的存在下使寡糖与甲硅烷基化保护剂反应; 并且（c）从反应混合物中回收单甲硅烷基化的寡糖衍生物。 升