公开(公告)号：EP0668878A4

公开(公告)日：1996-06-26

申请号：EP93923246

申请日：1993-10-05

申请人： MCKENZIE MAUREEN A

发明人： MCKENZIE MAUREEN A

IPC分类号： C07K14/39 ,  C07K14/72 ,  C07K15/04 ,  A61K38/16 ,  C12N9/12 ,  C07K15/14

CPC分类号： C07K14/72 ,  C07K14/39 ,  G01N2333/62 ,  G01N2333/72 ,  G01N2333/9121 ,  Y10S530/824

摘要： An insulin-like polypeptide isolated from yeast cultures is described. The protein elicits in yeast upon binding to a specific receptor many of the physiologic responses characteristic of those observed in mammalian cells upon binding of insulin to the mammalian insulin receptor.

摘要翻译： 从酵母膜纯化胰岛素样多肽的受体。 这种“胰岛素受体样蛋白”具有类似于哺乳动物胰岛素受体的结构。 酿酒酵母的胰岛素受体样蛋白是异四聚体糖蛋白。 该蛋白质具有两种多肽类型，其是结合胰岛素并具有135,000至145,000道尔顿的表观分子量的第一多肽，以及表观分子量为90,000至95,000道尔顿的第二多肽，并且响应于胰岛素的结合在酪氨酸上磷酸化 通过所述第一多肽。 第一和第二多肽通过二硫键连接。 该蛋白质需要二价金属离子作为胰岛素结合的酪氨酸自磷酸化反应。 酵母胰岛素受体样蛋白以Kd = 8×10 -10 M的解离常数结合人胰岛素，并以Kd = 4×10 -10 M结合人类胰岛素样生长因子1。

公开(公告)号：EP0689052A3

公开(公告)日：1996-04-24

申请号：EP95610040.8

申请日：1995-06-23

申请人： TOA MEDICAL ELECTRONICS CO., LTD.

发明人： Fukuda, Shigehiro, c/o Toa Medical Elec. Co., Ltd.

IPC分类号： G01N33/96 ,  G01N33/74

CPC分类号： G01N33/74 ,  G01N33/96 ,  G01N2333/62

摘要： An insulin standard solution including an amide derivative of bile acid as a stabilizer having the formula (I):

wherein A is a hydrogen atom or hydroxyl group, B has the formula :

or

and C is a hydrogen atom or a group having the formula :

公开(公告)号：EP0567567A4

公开(公告)日：1994-05-11

申请号：EP92904444

申请日：1992-01-17

申请人： UNIV NEW YORK

发明人： SCHLESSINGER JOSEPH ,  SKOLNIK EDWARD Y ,  MARGOLIS BENJAMIN L

IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K1/22 ,  C07K14/47 ,  C07K14/475 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/01 ,  G01N33/53

CPC分类号： C07K14/4705 ,  A61K38/00 ,  C07K14/475 ,  C07K14/705 ,  C07K14/71 ,  C07K16/2863 ,  C07K2317/34 ,  C07K2319/00 ,  G01N2333/62 ,  G01N2333/72 ,  G01N2333/9121

公开(公告)号：EP0227351A2

公开(公告)日：1987-07-01

申请号：EP86309432.2

申请日：1986-12-03

申请人： SHIONOGI & CO., LTD.

发明人： Tetsuo, Tsuji ,  Masao, Kono ,  Ken, Inouye

IPC分类号： G01N33/68 ,  G01N33/543

CPC分类号： G01N33/54353 ,  G01N33/68 ,  G01N33/74 ,  G01N2333/62

摘要： An antibody immobilized on a water-insoluble solid support by a heterobifunctional cross-linking reagent, wherein said antibody is a partially reduced form of immunoglobulin specific to human proinsulin C-peptide and usually having thiol groups, is disclosed. The solid support may have amino groups and the cross-­linking reagent is generally capable of forming two bonds, one with one of the thiol groups and the other with one of the amino groups. The antibody is useful in conducting immunoassays for proinsulin C-peptide in body fluids.

摘要翻译： 公开了通过异双功能交联剂固定在水不溶性固体支持物上的抗体，其中所述抗体是人胰岛素原C-肽特异性并且通常具有硫醇基的部分还原形式的免疫球蛋白。 固体支持物可以具有氨基，并且交联试剂通常能够形成两个键，一个与一个硫醇基团，另一个与一个氨基基团形成。 该抗体可用于对体液中的胰岛素原C肽进行免疫测定。

公开(公告)号：EP2790721B1

公开(公告)日：2018-10-17

申请号：EP12829142.4

申请日：2012-12-14

申请人： Alizé Pharma SAS

发明人： VAN DER LELY, Aart Jan ,  ABRIBAT, Thierry

IPC分类号： A61K38/08 ,  A61K38/12 ,  A61K38/25 ,  G01N33/74 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07K14/575 ,  A61K38/08 ,  A61K38/12 ,  A61K38/2264 ,  A61K38/25 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  G01N33/74 ,  G01N2333/62 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/52

摘要： A method and a composition for decreasing ghrelin levels and/or decreasing ghrelin/unacylated ghrelin ratio in a subject, the method comprising administering an effective amount of unacylated ghrelin, a fragment thereof, an analog thereof and/or pharmaceutically acceptable salts thereof to the subject wherein a reduction in ghrelin levels and/or a reduction in ghrelin/unacylated ghrelin ratio is beneficial to the subject. Also, use of ghrelin level and/or ghrelin/unacylated ghrelin ratio as biomarkers for determining a subject's likelihood of responding to and/or benefiting from administration of unacylated ghrelin.

公开(公告)号：EP3362793A1

公开(公告)日：2018-08-22

申请号：EP16855047.3

申请日：2016-10-15

申请人： Biocon Limited

发明人： KULSHRESTHA, Abhishek ,  MAURYA, Ravi, Shankar ,  SABDE, Sudeep ,  HAJELA, Pallavi ,  KALANI, Pawan ,  MELARKODE, Ramakrishnan ,  CHIRMULE, Narendra

IPC分类号： G01N33/50

CPC分类号： G01N33/74 ,  G01N33/50 ,  G01N33/5005 ,  G01N2333/62 ,  G01N2333/72 ,  G01N2500/10

摘要： The present invention provides an in vitro method for detecting the presence of neutralizing antibodies against recombinant human insulin (rHI) in human serum. It also provides a kit for an in vitro method of detection of the presence of recombinant human insulin (rHI) neutralizing antibodies.

公开(公告)号：EP2265641B1

公开(公告)日：2018-01-24

申请号：EP09719459.1

申请日：2009-03-12

申请人： Otago Innovation Limited

发明人： PEMBERTON, Christopher Joseph ,  RICHARDS, Arthur Mark ,  NICHOLLS, Michael Gary ,  YANDLE, Timothy Grant

IPC分类号： C07H21/04 ,  C07K14/16 ,  C07K16/18 ,  G01N33/74

CPC分类号： C07H21/04 ,  C07K14/62 ,  C07K16/18 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/62 ,  G01N2800/042 ,  G01N2800/324 ,  G01N2800/50

摘要： The invention provides binding agents and assays tor insulin signal peptide. The agents and assays are useful in methods tor predicting, diagnosing, assessing or monitoring acute cardiac disorders, glucose handling disorders and diabetes in a subject. Also provided are nucleotides, polypeptides, and kits useful in the methods of the invention.

公开(公告)号：EP2909311A4

公开(公告)日：2016-05-25

申请号：EP13846713

申请日：2013-10-11

申请人： UNIV KANSAS

发明人： STEHNO-BITTEL LISA ,  RAMACHANDRAN KARTHIK ,  RAWAL SONIA

IPC分类号： C12N5/00 ,  A01N1/02 ,  A61K35/28 ,  A61K35/39 ,  A61K48/00 ,  A61P37/06 ,  C12N5/071 ,  C12Q1/00 ,  G01N33/50 ,  G01N33/543 ,  G01N33/74

CPC分类号： C12N5/0677 ,  A01N1/0221 ,  A01N1/0284 ,  A61K35/28 ,  A61K35/39 ,  A61K2035/124 ,  C12N2502/1358 ,  C12N2502/22 ,  C12N2533/12 ,  C12N2535/00 ,  G01N33/5044 ,  G01N33/54393 ,  G01N33/74 ,  G01N2333/62

摘要： Described herein are 3-dimensional clusters of reaggregated cells comprising cells reaggregated from at least two different cell sources, such as different cell types, different donors, and combinations thereof. Methods of making, using, and cryopreserving these 3-dimensional clusters of reaggregated cells are also described herein.

公开(公告)号：EP2980586A1

公开(公告)日：2016-02-03

申请号：EP14775665.4

申请日：2014-03-31

申请人： Sekisui Medical Co., Ltd.

发明人： KONDOU, Junichi ,  NIIYAMA, Kanami ,  YAMAMOTO, Mitsuaki

IPC分类号： G01N33/53 ,  G01N33/531 ,  G01N33/543

CPC分类号： G01N33/5306 ,  G01N33/54393 ,  G01N33/74 ,  G01N2333/62

摘要： Provided herein is a human insulin latex agglutination immunoassay and assay reagents with which nonspecific reaction in a blood sample assay can be suppressed. The assay performs an immunoreaction with anti-insulin antibody-immobilized particles in a buffer containing two or more amine compounds having a pH buffering effect.

摘要翻译： 本文提供了可以抑制血液样品测定中的非特异性反应的人胰岛素胶乳凝集免疫测定和测定试剂。 该试验在含有两种或更多种具有pH缓冲作用的胺化合物的缓冲液中与抗胰岛素抗体固定颗粒进行免疫反应。

公开(公告)号：EP2545185A4

公开(公告)日：2015-09-09

申请号：EP11754192

申请日：2011-03-11

申请人： UNIV VIRGINIA PATENT FOUND

发明人： BRETON MARC D ,  PATEK STEPHEN D ,  KOVATCHEV BORIS P ,  HUGHES COLLEEN S

IPC分类号： G06F19/00 ,  C12Q1/54 ,  G01N33/50

CPC分类号： A61M5/1684 ,  A61M5/16836 ,  G01N33/74 ,  G01N2333/62 ,  G01N2800/042 ,  G06F19/3468

摘要： An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.