公开(公告)号：EP2931293A4

公开(公告)日：2016-08-31

申请号：EP13862444

申请日：2013-12-11

Applicant: UNIV VIRGINIA PATENT FOUND ,  BRACIALE THOMAS J ,  KIM TAEG S

Inventor： BRACIALE THOMAS J ,  KIM TAEG S

IPC: A61K35/28 ,  A61K35/12 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P7/06 ,  C07K16/28

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/75

Abstract: The present application discloses a previously unknown function of CD24 expressed on a subset of dendritic cells. The invention encompasses regulating CD24 on these cells to regulate erythropoiesis, induce EPO production and levels, increase RBC levels, and to treat, for example, stress-mediated erythropoiesis. The compositions and methods of the invention are useful, for example, in treating anemia.

公开(公告)号：EP2651285A4

公开(公告)日：2016-05-18

申请号：EP11848242

申请日：2011-12-13

Applicant: UNIV VIRGINIA PATENT FOUND

Inventor： YATES PAUL A ,  TRAN KENNETH

IPC: A61B3/10

CPC classification number: A61B3/152 ,  A61B3/0008 ,  A61B3/0033 ,  A61B3/0075 ,  A61B3/0091 ,  A61B3/12 ,  A61B3/1208 ,  A61B3/14 ,  H04N5/23212

Abstract: Apparatus and techniques can include using one or more of a portable or fixed optical system to obtain images of a desired anatomical target, such as the fundus region of a human eye. The optical system can include one or more of a laser-based focusing target, a laser-based fixation target, or a removable or adjustable alignment assembly. Such an alignment assembly can provide or allow user alignment based on using anatomical landmarks other than the fundus being imaged. One or more of the apparatus or techniques can be implemented in an optical assembly included as a portion hand-held fundus camera, such as including or using a consumer or commercial digital camera to capture an image.

Abstract translation: 装置和技术可以包括使用便携式或固定光学系统中的一种或多种来获得期望的解剖目标的图像，例如人眼的眼底区域。 光学系统可以包括基于激光的聚焦目标，基于激光的固定目标或可移除或可调整的对准组件中的一个或多个。 这种对准组件可以基于使用除被成像的眼底之外的解剖学标记来提供或允许用户对准。 该装置或技术中的一个或多个可以在包括作为部分手持眼底照相机的光学组件中实现，例如包括或使用消费者或商业数字照相机来捕获图像。

公开(公告)号：EP2839281A4

公开(公告)日：2016-05-11

申请号：EP13777937

申请日：2013-04-22

Applicant: UNIV VIRGINIA PATENT FOUND ,  FELDER ROBIN A ,  CAREY ROBERT M ,  JONES JOHN E ,  JOSE PEDRO A ,  WILLIAMS SCOTT M

Inventor： FELDER ROBIN A ,  CAREY ROBERT M ,  JONES JOHN E ,  JOSE PEDRO A ,  WILLIAMS SCOTT M

IPC: G01N33/68 ,  A23L33/00 ,  A61K31/00 ,  C12N15/11 ,  C12Q1/68

CPC classification number: C12Q1/6883 ,  A23L33/30 ,  A23V2002/00 ,  C12Q2600/118 ,  C12Q2600/156 ,  G01N33/6893 ,  G01N33/84 ,  G01N2800/321

公开(公告)号：EP2880175A4

公开(公告)日：2016-04-06

申请号：EP13826087

申请日：2013-08-05

Applicant: UNIV VIRGINIA PATENT FOUND

Inventor： ORTIZ EDWARD A ,  PATEK STEPHEN D ,  BRETON MARC D ,  FARHI LEON S ,  KOVATCHEV BORIS P

IPC: C12Q1/54 ,  C12Q3/00 ,  G06F19/00 ,  G06G7/48

CPC classification number: G06F19/3437 ,  C12Q1/54 ,  G16H50/50

Abstract: Time-varying hyperglycemic stresses are derived from actual ICU patients and applied to non-critically ill virtual patients, using any model of normal glucose-insulin physiology that fulfills certain requirements, in order to model and simulate stress hyperglycemia. Other aspects provide: 1) a methodology to perform sensitivity analyses of the parameters of ICU insulin infusion therapy protocols and to improve the protocols; and 2) a training system for clinicians about the course and management of stress hyperglycemia in the ICU or other facility.

公开(公告)号：EP2875706A4

公开(公告)日：2016-03-23

申请号：EP13820497

申请日：2013-07-18

Applicant: UNIV VIRGINIA PATENT FOUND

Inventor： HAJ-HARIRI HOSSEIN ,  MIRALIPOUR SEYED REZA MONAZAMI

IPC: H05K7/20

CPC classification number: F28D15/04 ,  B64G1/50 ,  B64G1/58 ,  F01D5/187 ,  F05D2210/14 ,  F05D2260/207 ,  F05D2260/213 ,  F25B21/02 ,  F28D15/02 ,  F28D15/046 ,  F28F13/187 ,  H01L23/427 ,  H01L2924/0002 ,  Y02T50/676 ,  H01L2924/00

公开(公告)号：EP2583069A4

公开(公告)日：2015-10-28

申请号：EP11796503

申请日：2011-06-17

Applicant: UNIV VIRGINIA PATENT FOUND

Inventor： PATE BROOKS HART ,  LEHMANN KEVIN K

IPC: G01J3/28 ,  G01J3/10 ,  G01J3/433 ,  G01N21/3586 ,  G01N22/00 ,  H01S3/00

CPC classification number: G01N21/3586 ,  G01J3/10 ,  G01J3/4338 ,  G01J3/44 ,  G01N21/31 ,  G01N21/62 ,  G01N21/67 ,  G01N21/69 ,  G01N22/00 ,  H01S3/0057

Abstract: A pulse train comprising chirped pulses of electromagnetic energy can be used to excite a sample, such as for spectroscopic analysis. The respective chirped pulses can include a frequency sweep across a first specified bandwidth during a respective chirped pulse duration, the respective chirped pulse duration establishing a first frequency-domain comb peak separation. A width of a frequency-domain comb peak can be established at least in part by a total duration of the pulse train, and a bandwidth of the first frequency-domain comb can be determined at least in part by the first specified bandwidth of the frequency sweep of the respective chirped pulses.

Abstract translation: 可以使用包括啁啾脉冲的脉冲串来激发样品，例如用于光谱分析。 相应的啁啾脉冲可以包括频率扫描以建立第一频域梳。 频域梳状峰值的宽度可以至少部分地由脉冲序列的总持续时间建立，并且可以至少部分地由第一频域梳状信号的频率扫描的带宽确定第一频域梳状的带宽 各自的啁啾脉冲。 可以使用自由空间或封闭的样品相互作用区域。

公开(公告)号：EP2488614A4

公开(公告)日：2015-10-21

申请号：EP10824178

申请日：2010-10-15

Applicant: UNIV VIRGINIA PATENT FOUND

Inventor： CLARENS ANDRES F ,  ALLAIRE PAUL E ,  YOUNAN AMIR ,  WANG SHIBO

IPC: C10M107/00 ,  C10M169/04 ,  C10M171/00 ,  C10N50/06 ,  F16C33/66 ,  F16N7/30 ,  F16N7/32

CPC classification number: C10M169/04 ,  C10M111/04 ,  C10M171/005 ,  C10M2201/04 ,  C10M2201/0403 ,  C10M2201/16 ,  C10M2203/1006 ,  C10M2205/0285 ,  C10M2207/2835 ,  C10M2209/1033 ,  C10N2230/02 ,  C10N2230/58 ,  C10N2240/02 ,  C10N2250/06 ,  F16C17/03 ,  F16C33/6662 ,  F16N7/30 ,  F16N7/32

Abstract: Method and System of lubricating at least one moving part with a medium. The medium includes a dissolved mixture of lubricant and compressed gas. The amount of lubricant and compressed gas may be controlled in forming the dissolved mixture in response to input conditions. A user and/or external factors may be used to determine the input conditions. In response to the input conditions the amount of lubricant and compressed gas is delivered to the moving part that is housed in a pressurized chamber. The properties of the dissolved mixture can be adjusted, whereby the properties may include, but are not limited to, the following: viscosity, temperature, and thermal conductivity. This adjustment to the gas may be accomplished, for example, by releasing gas from the pressurized chamber in an amount to adjust the properties. In a further approach, lubricant may be scavenged from the pressurized chamber by returning surplus lubricant to its original source or other designated location.

公开(公告)号：EP2701607A4

公开(公告)日：2015-09-16

申请号：EP12777556

申请日：2012-04-25

Applicant: UNIV VIRGINIA PATENT FOUND

Inventor： MAULDIN F WILLIAM JR ,  HOSSACK JOHN A ,  OWEN KEVIN

IPC: A61B8/14 ,  A61B8/00 ,  A61B8/08 ,  A61B17/34 ,  A61B19/00 ,  G01S7/52 ,  G01S15/60 ,  G01S15/89

CPC classification number: A61B8/0875 ,  A61B8/0841 ,  A61B8/4245 ,  A61B8/4254 ,  A61B8/4433 ,  A61B8/4455 ,  A61B8/4466 ,  A61B8/4483 ,  A61B8/466 ,  A61B8/483 ,  A61B34/20 ,  A61B2017/3413 ,  A61B2034/2048 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/378 ,  A61B2090/3937 ,  G01S7/52073 ,  G01S7/5208 ,  G01S15/60 ,  G01S15/8915 ,  G01S15/899

Abstract: An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4λ2, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about ½λ, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.

公开(公告)号：EP2751137A4

公开(公告)日：2015-06-03

申请号：EP12830779

申请日：2012-09-07

Applicant: UNIV VIRGINIA PATENT FOUND

Inventor： JOHNSON BANKOLE A

IPC: A61K31/4178 ,  A61P25/30 ,  C12Q1/68

CPC classification number: A61K31/4178 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

公开(公告)号：EP2689231A4

公开(公告)日：2014-11-19

申请号：EP12762971

申请日：2012-03-23

Applicant: UNIV VIRGINIA PATENT FOUND

Inventor： LEHMANN KEVIN K

IPC: H01S3/105 ,  G01J3/42 ,  G01N21/03 ,  G01N21/39

CPC classification number: G01N21/0303 ,  G01J3/42 ,  G01N2021/0364 ,  G01N2021/391