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81.发明公开RADIOACTIVE METAL-LABELED ANTI-CADHERIN ANTIBODY 有权MIT EINEM RADIOAKTIVEN金属GEKENNZEICHNETERANTIKÖRPERGEGEN CADHERIN
公开(公告)号：EP2535358A4
公开(公告)日：2013-07-10
申请号：EP11742267
申请日：2011-02-09
发明人： HINO AKIHIRO , NAGANO AKIO , WATANABE MASAHIKO , MATSUURA TADASI , SATOH HIROKAZU , NOMURA FUMIKO , MITOMO KATSUYUKI
CPC分类号： A61K51/1027 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/46 , C07K2317/24 , C12N15/02 , C12N15/85
摘要： An object of the present invention is to provide a radioactive metal anti-cadherin antibody which is highly accumulated specifically in cancer tissue. Another object is to provide a cancer therapeutic agent having high anti-cancer effect and safety and a cancer diagnostic agent. The radioactive metal-labeled anti-cadherin antibody which is obtained by binding a radioactive metallic element to an anti-cadherin antibody via a metal-chelating reagent.
摘要翻译： 本发明的目的是提供一种在癌组织中高度积聚的放射性金属抗钙粘蛋白抗体。 另一个目的是提供具有高抗癌作用和安全性的癌症治疗剂和癌症诊断剂。 放射性金属标记的抗钙粘蛋白抗体，其通过金属螯合剂将放射性金属元素与抗钙粘蛋白抗体结合而获得。
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82.发明公开Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents 审中-公开Radioaktiv markierte Dihydrotetrabenazinderivate und deren Verwendung als Bildgebungsmittel
公开(公告)号：EP2604290A2
公开(公告)日：2013-06-19
申请号：EP13152239.3
申请日：2007-05-01
IPC分类号： A61K51/00 , A61P43/00 , C07D455/06 , A61K51/04
CPC分类号： A61K51/0455
摘要： This invention relates to a method of imaging vesicular monoamine transporters and to labeled compounds and pharmaceutical compositions thereof, and methods of making labeled compounds useful in imaging vesicular monoamine transporters. This invention also relates to compounds, and methods of monitoring progression of a disease related to vesicular monoamine transporters.
摘要翻译： 本发明涉及一种影像囊状单胺转运蛋白和标记化合物及其药物组合物的方法，以及制备用于成像囊泡单胺转运蛋白的标记化合物的方法。 本发明还涉及化合物和监测与囊泡单胺转运蛋白相关疾病进展的方法。
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83.发明公开METHOD FOR HIGH-SPEED FLUOROMETHYLATION AND PROCESS FOR PREPARATION OF PET TRACER USING SAME 有权METHOD FOR HIGH-SPEED FLUOR-甲基化和SO生产PET示踪方法
公开(公告)号：EP2508505A4
公开(公告)日：2013-05-29
申请号：EP10834631
申请日：2010-12-03
申请人： RIKEN
发明人： SUZUKI MASAAKI , DOI HISASHI , GOTO MIKI
IPC分类号： C07C67/343 , A61K51/00 , C07B59/00 , C07B61/00 , C07C69/76 , C07D311/30 , G01T1/161
CPC分类号： C07D311/30 , A61K51/04 , A61K51/0421 , C07B59/001 , C07B2200/05 , C07C67/343 , C07C69/76
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公开(公告)号：EP2119458B1
公开(公告)日：2013-05-15
申请号：EP08711095.3
申请日：2008-02-12
CPC分类号： C07C229/48 , A61K9/0019 , A61K47/26 , A61K51/0402 , A61K51/0406 , C07B59/001 , C07B63/04 , C07B2200/05 , C07C2601/04
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公开(公告)号：EP2588146A1
公开(公告)日：2013-05-08
申请号：EP11801314.3
申请日：2011-06-09
申请人： Quillin, Robert L.
发明人： Quillin, Robert L.
CPC分类号： A61K31/519
摘要： Provided herein are methods of treating neuropsychiatric disorders or improving the symptoms associated therewith administering a medical food, such as L-methylfolate, to a subject having the disorder. The neuropsychiatric disorder may be an autism spectrum disorder or attention deficit disorder with or without hyperactivity (ADD/ADHD). The L-methylfolate may be administered as an adjunct to other therapeutic agents effective to treat the disorder. The subject preferably may be a child and also may have a single nucleotide polymorphism in the
MTHFR gene associated with reduced expression of MTHFR enzyme. Also provided is a method of increasing the de novo synthesis of neurotransmitters in vivo by transporting a methyl-donating compound across the blood-brain barrier in a subject.-
86.发明公开FLUORESCENT PHOSPHOLIPID ETHER COMPOUNDS, COMPOSITIONS, AND METHODS OF USE 有权荧光PHOSPHOLIPIDETHERVERBINDUNGEN和组合物，及其使用方法
公开(公告)号：EP2429591A4
公开(公告)日：2013-02-20
申请号：EP10775385
申请日：2010-05-11
申请人： CELLECTAR INC
IPC分类号： A61K51/00 , A61K49/00 , A61M36/14 , C07F9/572 , C07F9/6558 , C07F9/6561
CPC分类号： A61K49/0021 , A61K49/0017 , A61K49/0032 , A61K49/0052 , C07F9/5728 , C07F9/65583 , C07F9/6561
摘要： The invention generally relates to novel fluorescent phospholipid compounds, compositions comprising these compounds, and diagnostic methods utilizing these compounds. A preferred compound of the present invention has the following structural formula:
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公开(公告)号：EP2342197B1
公开(公告)日：2013-01-16
申请号：EP09737459.9
申请日：2009-10-26
发明人： ALBERATI, Daniela , BORRONI, Edilio Maurizio , HARTUNG, Thomas , NORCROSS, Roger , PINARD, Emmanuel
IPC分类号： C07D405/10 , A61K51/00
CPC分类号： C07D405/10
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公开(公告)号：EP1898962A4
公开(公告)日：2013-01-09
申请号：EP06785507
申请日：2006-06-23
申请人： BRACCO IMAGING SPA
发明人： CAPPELLETTI ENRICO , LATTUADA LUCIANO , LINDER KAREN E , MARINELLI EDMUND R , NANJAPPAN PALANIAPPA , RAJU NATARAJAN , RAMALINGAM KONDAREDDIAR , SWENSON ROLF E , TWEEDLE MICHAEL F
CPC分类号： A61K51/088 , A61K49/0002 , C07C269/04 , C07D257/00 , C07J41/0005 , C07J41/0011 , C07J43/003 , C07K14/57572 , C07C271/22
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89.发明授权Dispositif stérile à usage unique de préparation d'un médicament radiopharmaceutique, système et procédé mettant en oeuvre ce dispositif 有权用于制备放射性药物，系统和方法，该装置的应用的无菌一次性装置
公开(公告)号：EP2179926B1
公开(公告)日：2012-12-19
申请号：EP09173372.5
申请日：2009-10-19
发明人： Vuillemard, Catherine , Douysset, Guilhem , Corpace, Olivier , Lotrus, Paul , Duboue, Bruno , Coulon, Christine
CPC分类号： B65B3/003 , A61M5/007 , A61M2039/0009 , A61M2209/045 , B65B2210/06 , G21F5/015
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公开(公告)号：EP2212319A4
公开(公告)日：2012-12-12
申请号：EP08845214
申请日：2008-10-31
发明人： STERZINGER CHRIS , FERREIRA CARA , LEYH DAVID
IPC分类号： C07D451/02 , A61K51/00 , G01N33/60
CPC分类号： A61K51/0455 , A61K51/0448 , C07D451/02 , G21H5/02
摘要： A diagnostic formulation is provided comprising a tropane having a radioactive concentration of at least 1.6 mCi/mL at least about 51 hours post creation. The diagnostic formulation optionally comprises a radiolabeled dopamine transporter (DAT) ligand useful in the diagnosis of Parkinson's disease (PS). One example of a radiolabeled dopamine transporter (DAT) ligand example is [123I]-2beta-carbomethoxy-3beta-(4-flurophenyl)-N-(3-iodo-E-allyl) nortropane.
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