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公开(公告)号：EP2970512A4
公开(公告)日：2016-11-09
申请号：EP14779937
申请日：2014-03-10
申请人： BIOCON LTD
CPC分类号： C07K16/2863 , A61K38/00 , C07K14/705 , C07K14/71 , C07K16/2818 , C07K2317/40 , C07K2317/526 , C07K2317/90 , C07K2319/00 , C12N15/62
摘要： The present invention relates generally to the field of generating recombinant chimeric fusion proteins to be used in the cancer therapy, and more specifically, to fusion molecules of Anti-EGFR1-TGFβRII, Anti-EGFR1-PD1 and Anti-CTLA4-PD1 and methods of generating same, wherein the methods reduce production costs and increase homogeneity of the recombinant chimeric fusion proteins.
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3.发明公开
公开(公告)号：EP2475771A4
公开(公告)日：2013-04-03
申请号：EP09849148
申请日：2009-10-26
申请人： BIOCON LTD
发明人： GOVINDAPPA NAGARAJ , NATARAJ NANDINI , TIWARI SANJAY , HAZRA PARTHA , PATALE MUKESH BABUAPPA , JOTHIRAMAN GOKUL , SASTRY KEDARNATH
CPC分类号： C12N9/20 , C07K2319/00 , C12N9/6424 , C12N9/6427 , C12P21/06
摘要： The present invention relates to novel Prolipase-Bovine trypsinogen (PLBTR) fusion proteins, the genes encoding them, and the production and uses thereof. More specifically, the present invention relates to methods of producing in optimal quantities PLBTR fusion proteins which comprise a heterologous polypeptide which is normally susceptible to autocatalytic activity. More particularly, the present invention relates to fusion proteins which comprise an heterologous polypeptide, such as a serine protease, fused to a lipase signal sequence, which can be expressed by recombinant host cells in desired amounts. The present invention further relates to polynucleotides encoding such fusion proteins, to expression vectors for expression of such fusion proteins, to host cells transformed with such polynucleotides/vectors, and to methods of generating such fusion proteins.
摘要翻译： 本发明涉及新型的脂肪酶 - 牛胰蛋白酶原（PLBTR）融合蛋白，编码它们的基因及其生产和用途。 更具体地说，本发明涉及生产最佳量的PLBTR融合蛋白的方法，所述PLBTR融合蛋白包含通常对自身催化活性敏感的异源多肽。 更具体地，本发明涉及融合蛋白，其包含与脂肪酶信号序列融合的异源多肽，例如丝氨酸蛋白酶，其可以由重组宿主细胞以所需量表达。 本发明还涉及编码这种融合蛋白的多核苷酸，用于表达这种融合蛋白的表达载体，用于用这种多核苷酸/载体转化的宿主细胞，以及产生这种融合蛋白的方法。
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4.发明公开A NOVEL PROCESS FOR THE PREPARATION OF PROSTAGLANDINS AND INTERMEDIATES THEREOF 审中-公开新工艺用于生产前列腺素及其中间体
公开(公告)号：EP2496553A4
公开(公告)日：2013-03-06
申请号：EP09851063
申请日：2009-12-21
申请人： BIOCON LTD
发明人： ASWATHANARAYANAPPA CHANDRASHEKAR , SRINIVAS PULLELA VENKATA , KANGATH DIVYA , SOUNDARARAJAN THILAK GREGORY , PRASAD ANEGONDI SREENIVASA , RAGHAVENDRAN SURIYAN MASINAICKENPATTY
IPC分类号： C07C405/00 , A61K31/5575 , A61P27/06 , C07D307/935
CPC分类号： C07D307/935 , A61K31/5575 , C07C405/00 , C07C2601/08
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5.发明公开AN ORALLY ADMINISTERABLE SOLID PHARMACEUTICAL COMPOSITION AND A PROCESS THEREOF 有权ENSURE口服固体药物组合物及方法
公开(公告)号：EP2203181A4
公开(公告)日：2013-01-16
申请号：EP08840520
申请日：2008-10-16
申请人： BIOCON LTD
发明人： KHEDKAR ANAND , RANGAPPA SHARATH KUMAR MALLAPURA , SUBRAMANI RAMESH , DAVE NITESH , RADHAKRISHNAN DEVESH , SHANKAR SUNDARESH , CHIVUKULA SUDHEER , RAMAKRISHNA RANJITH , MURTHY SHANMUGAM THANDAVA , PAI HARISH VENKATRAMAN , SENGUPTA NILANJAN , MELARKODE RAMAKRISHNAN , IYER HARISH
CPC分类号： A61K9/2077 , A61K9/1617 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K38/28 , A61K47/542 , A61K47/543
摘要： The invention relates to improvised pharmaceutical compositions permitting ingestion via oral delivery of proteins/peptides or their conjugates, and/or cation-insulin conjugate complexes demonstrating desirable pharmacokinetic profiles and potency in efficacy models of diabetes in dogs and humans. A preferred formulation comprises 0.01%-20% w/w of insulin, insulin compound conjugates and/or cation insulin conjugates, 10%-60% w/w of one or more fatty acid components selected from saturated or unsaturated C4-C12 fatty acids and/or salts of such fatty acids and additionally contains optimal amounts of other pharmaceutically suitable polymer excipients which permit improved solubility, dissolution rate and effective bioavailability of poorly water soluble compositions and consistent in-vivo release profiles upon scalability during manufacture. A further aspect of the invention features the process of preparing the aforesaid formulations.
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公开(公告)号：EP2016048A4
公开(公告)日：2010-06-23
申请号：EP06766269
申请日：2006-06-15
申请人： BIOCON LTD
IPC分类号： C07D207/335 , A61K31/40 , A61P3/06
CPC分类号： C07D207/34
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7.发明公开MIXTURES OF CALCITONIN DRUG-OLIGOMER CONJUGATES AND METHODS OF USE IN PAIN TREATMENT 审中-公开药物降钙素低聚物结合物和混合物使用的疼痛治疗方法
公开(公告)号：EP1643959A4
公开(公告)日：2010-06-09
申请号：EP04753588
申请日：2004-05-27
申请人： BIOCON LTD
IPC分类号： C07K1/113 , A61K20060101 , A61K38/00 , A61K47/48 , C07K7/00 , C07K14/535
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8.发明公开A METHOD OF PRODUCING BIOLOGICALLY ACTIVE POLYPEPTIDE HAVING INSULINOTROPIC ACTIVITY 有权生产具有促胰岛素释放效应的生物学活性多肽
公开(公告)号：EP2038423A4
公开(公告)日：2009-12-09
申请号：EP07805625
申请日：2007-06-20
申请人： BIOCON LTD
发明人： MELARKODE RAMAKRISHNAN , SRIRAM AKUNDI VENKATA , SASTRY KEDARNATH NANJUND , VARADARAJALU LAKSHMI PRABHA , SURYANARAYAN SHRIKUMAR
CPC分类号： C07K14/46
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公开(公告)号：EP1773767A4
公开(公告)日：2009-10-28
申请号：EP05769456
申请日：2005-07-07
申请人： BIOCON LTD
IPC分类号： C07D207/09 , A61K31/4025 , C07D207/10
CPC分类号： C07C245/08
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10.发明公开POLYMORPHS OF [R-(R*, R*)]-2-(4-FLUOROPHENYL)- BETA,DELTA -DIHYDROXY-5-(L-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-lH-PYRROLE-l-HEPTANOIC ACID MAGNESIUM SALT (2: 1) 审中-公开2-（4-氟苯基）-β，δ-二羟基-5-（1-甲基乙基）-3-苯基-4 - - [（苯基氨基）羰基] -1H- [R-（R *，R *）]的多晶型 - 吡咯-1-庚酸，镁盐（2：1）
公开(公告)号：EP1963263A4
公开(公告)日：2009-09-02
申请号：EP05823667
申请日：2005-11-29
申请人： BIOCON LTD
IPC分类号： C07D207/335 , A61K31/40 , A61P3/06
CPC分类号： C07D207/327
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