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公开(公告)号:EP0269712A4
公开(公告)日:1990-06-26
申请号:EP87903968
申请日:1987-06-09
申请人: BIOGEN NV , GILBERT WALTER
IPC分类号: A61K38/00 , A61K39/00 , A61P31/12 , C07K7/08 , C07K14/00 , C07K14/155 , C07K14/16 , C07K14/705 , C07K16/10 , C07K19/00 , G01N33/569
CPC分类号: C07K14/005 , A61K38/00 , A61K39/00 , C07K16/1063 , C12N2740/16122
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2.DNA SEQUENCES CODING FOR MODIFIED FACTOR VIII:C AND MODIFIED FACTOR VIII:C-LIKE POLYPEPTIDES AND PROCESSES FOR PRODUCING THESE POLYPEPTIDES IN HIGH YIELDS. 失效
标题翻译: DNA序列替代修饰的因子VIII:C代码,所述修饰的因子VIII:C相关多肽AND METHOD FOR PRODUCING这些多肽大量。公开(公告)号:EP0275305A4
公开(公告)日:1988-11-07
申请号:EP87905356
申请日:1987-07-31
申请人: BIOGEN NV , PASEK MARK P
发明人: BIOGEN N V
IPC分类号: C12N15/09 , A61K38/00 , A61K38/46 , A61P7/02 , A61P7/04 , C07H21/04 , C07K14/00 , C07K14/745 , C07K14/755 , C12N15/00 , C12N15/85 , C12P21/02 , C12R1/19
CPC分类号: C07K14/755 , A61K38/00 , C12N15/85
摘要: DNA sequences coding on expression for modified factor VIII:C and modified factor VIII:C-like polypeptides and methods of making them in high yields in appropriate hosts transformed with those DNA sequences. DNA sequences containing internal deletions removing a major part of the sequence which codes on expression for the maturation polypeptide of factor VIII:C express modified factor VIII:C and modified factor VIII:C-like polypeptides 20 times more efficiently than DNA sequences coding for the factor VIII:C.
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3.COMBINATIONS OF GAMMA INTERFERONS AND ANTI-INFLAMMATORY OR ANTI-PYRETIC AGENTS FOR TREATING DISEASES. 无效
标题翻译: 融合对疾病治疗的伽马干扰素和抗发炎剂或解热资金。公开(公告)号:EP0311616A4
公开(公告)日:1989-05-23
申请号:EP87903945
申请日:1987-06-01
申请人: BIOGEN NV , REICH STEVEN D
发明人: REICH STEVEN D
IPC分类号: A61K31/19 , A61K31/405 , A61K31/415 , A61K31/60 , A61K38/21 , A61K45/06 , A61P29/00 , A61P35/00 , A61P37/08
CPC分类号: A61K38/217 , A61K31/60 , A61K31/57 , A61K31/415 , A61K31/405 , A61K31/19 , A61K2300/00
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公开(公告)号:EP0302925A4
公开(公告)日:1989-04-24
申请号:EP88902010
申请日:1988-01-29
申请人: BIOGEN NV , PASEK MARK P
发明人: PASEK MARK P
IPC分类号: C12N15/09 , A61K38/00 , C07K1/22 , C07K14/00 , C07K14/745 , C07K14/755 , C12N5/10 , C12P21/00 , C12R1/91
CPC分类号: C07K14/755 , A61K38/00
摘要: The method comprises the addition of vWf to the medium in which factor VIII-producing cells are grown. According to this method, increased amounts of both recombinant factor VIII and native factor VIII are purified from cells producing factor VIII.
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5.COMBINATIONS OF TUMOR NECROSIS FACTORS AND ANTI-INFLAMMATORY AGENTS FOR TREATING MALIGNANT AND NON-MALIGNANT DISEASES. 失效
标题翻译: 肿瘤坏死因子和抗炎剂在恶性和非恶性疾病治疗的组合。公开(公告)号:EP0287633A4
公开(公告)日:1989-02-23
申请号:EP87907079
申请日:1987-10-14
申请人: HARVARD COLLEGE , BIOGEN NV
CPC分类号: A61K38/191 , A61K31/60 , A61K31/19 , A61K31/415 , A61K2300/00
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公开(公告)号:EP0198015A4
公开(公告)日:1988-08-17
申请号:EP85905158
申请日:1985-10-01
申请人: MEADE HARRY M , GARWIN JEFFREY L , BIOGEN NV
发明人: MEADE HARRY M , GARWIN JEFFREY L
IPC分类号: C07H21/04 , C07K1/16 , C07K1/22 , C07K14/00 , C07K14/36 , C07K14/52 , C07K14/555 , C07K14/575 , C07K14/61 , C07K14/62 , C07K14/76 , C07K19/00 , C12N1/00 , C12N1/21 , C12N5/00 , C12N9/72 , C12N15/00 , C12N15/09 , C12N15/76 , C12P21/02 , C12R1/19 , C12R1/38 , C12R1/465 , C12R1/645
CPC分类号: C12N9/6459 , C07K14/36 , C07K2319/00 , C07K2319/22 , C12N15/76 , C12Y304/21069
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公开(公告)号:EP0227810A4
公开(公告)日:1987-12-01
申请号:EP86904563
申请日:1986-06-26
申请人: BIOGEN NV , MUCHMORE ANDREW V , DECKER JEAN M
发明人: MUCHMORE ANDREW V , DECKER JEAN M
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8.HUMAN GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR-LIKE POLYPEPTIDES AND PROCESSES FOR PRODUCING THEM IN HIGH YIELDS IN MICROBIAL CELLS. 失效
标题翻译: 人粒细胞 - 巨噬细胞集落刺激因子具有类似多肽及其以高收率在微生物细胞中生产。公开(公告)号:EP0238655A4
公开(公告)日:1989-09-11
申请号:EP86906562
申请日:1986-10-03
申请人: BIOGEN NV
发明人: DELAMARTER JOHN , ERNST JOACHIM F
IPC分类号: C12N15/09 , A61K38/00 , C07K14/00 , C07K14/52 , C07K14/53 , C07K14/535 , C12N1/14 , C12N1/20 , C12N15/70 , C12P21/02 , C12R1/19 , C12R1/865
CPC分类号: C07K14/535 , A61K38/00 , C12N15/70
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9.PRODUCTION OF A VITAMIN C PRECURSOR USING GENETICALLY MODIFIED ORGANISMS. 失效
标题翻译: 维生素-C FORERUNNER的制备转基因生物的装置。-
10.DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN-3. 失效
标题翻译: DNA序列的重组DNA分子和制备AT THE淋巴细胞功能相关抗原第三方法公开(公告)号:EP0315683A4
公开(公告)日:1990-02-05
申请号:EP88905552
申请日:1988-06-03
申请人: BIOGEN NV , DANA FARBER CANCER INST INC , WALLNER BARBARA P , SPRINGER TIMOTHY A , HESSION CATHERINE , TIZARD RICHARD , MATTALIANO ROBERT , DUSTIN MICHAEL L
发明人: WALLNER BARBARA P , SPRINGER TIMOTHY A , HESSION CATHERINE , TIZARD RICHARD , MATTALIAND ROBERT , DUSTIN MICHAEL L
IPC分类号: G01N33/53 , A61K38/00 , C07H21/04 , C07K14/00 , C07K14/435 , C07K14/705 , C12N1/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/569
CPC分类号: C07K14/70528 , A61K38/00 , G01N33/56972
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