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1.发明公开TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES 审中-公开标记的HEPADNAVIRUS E抗原及其在筛选抗病毒物质中的应用
公开(公告)号：EP3157944A1
公开(公告)日：2017-04-26
申请号：EP15733379.0
申请日：2015-06-19
发明人： GUO, Haitao , CAI, Dawei , CUCONATI, Andrea , JI, Changhua
IPC分类号： C07K14/005 , G01N33/576
CPC分类号： C07K14/005 , C07K2319/40 , C07K2319/42 , C12N2730/10122 , C12N2730/10151 , C12N2830/006 , G01N33/502 , G01N2333/02
摘要： The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
摘要翻译： 本发明涉及用于筛选抗肝炎病毒物质的方法和用途，其中所述物质筛选抑制肝炎病毒如乙型肝炎病毒的共价闭合环状（ccc）DNA的能力。 该方法和用途利用了包含编码标记的肝炎病毒e抗原的核酸序列如乙型肝炎病毒e抗原（HBeAg）的细胞。 此外，本发明提供了编码标记的肝炎病毒e抗原和由其编码的蛋白质的核酸序列。 还提供了用于筛选方法的试剂盒。
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2.发明公开SULFAMOYLBENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION 审中-公开磺胺苯丙氨酸甲酯抗炎药MITTEL GEGEN HBV-INFEKTIONEN
公开(公告)号：EP3085368A1
公开(公告)日：2016-10-26
申请号：EP16174324.0
申请日：2012-06-29
发明人： GUO, Ju-Tao , BLOCK, Timothy M. , XU, Xiaodong
IPC分类号： A61K31/167 , A61K31/18 , A61K31/14 , C07D211/06 , A61P31/20
CPC分类号： C07C311/46 , A61K31/167 , A61K31/18 , A61K31/341 , A61K31/44 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/553 , A61K2300/00 , C07D211/96 , C07D213/40 , C07D223/04 , C07D281/16 , C07D295/26 , C07D307/52 , C07D307/68
摘要： Pharmaceutical compositions of the invention comprise sulfamoylbenzamide derivative useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.
摘要翻译： 本发明的药物组合物包含可用作治疗乙型肝炎病毒（HBV）感染的预基因组RNA包封抑制剂的氨磺酰基苯甲酰胺衍生物。
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公开(公告)号：EP2854832A2
公开(公告)日：2015-04-08
申请号：EP13797412.7
申请日：2013-05-31
IPC分类号： A61K38/12 , C07K5/00 , A01N47/34 , C07D245/00
CPC分类号： A61K38/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K45/06 , C07K5/123 , C07K5/126
摘要： The present invention provides small molecule inhibitors of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, which are useful as therapeutics in the management of chronic HBV. The compounds of the invention achieve epigenetic modification of the cccDNA, histone modification and histone deacetylase activity inhibition, thus modulating HBV cccDNA. The present invention further provides methods for modulating HBV cccDNA, for treating or preventing HBV in a subject, and for modulating cccDNA transcription of hepatitis B in a subject.
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公开(公告)号：EP2726459B1
公开(公告)日：2019-09-11
申请号：EP12807810.2
申请日：2012-06-29
发明人： GUO, Ju-Tao , XU, Xiaodong , BLOCK, Timothy M.
IPC分类号： C07D211/06 , A61K31/167 , A61K31/18 , A61P31/14
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5.发明公开BINHIBITORS OF HEPATITIS B VIRUS CONVALENTLY CLOSED CIRCULAR DNA FORMATION AND THEIR METHOD OF USE 审中-公开乙型肝炎病毒具有共价闭合环状DNA SHAPING抑制剂和它们的使用方法
公开(公告)号：EP2819671A2
公开(公告)日：2015-01-07
申请号：EP13755289.9
申请日：2013-02-28
申请人： Baruch S. Blumberg Institute , Philadelphia Health and Education Corporation d/b/a Drexel University College of Medicine
发明人： CUCONATI, Andrea , GUO, Haitao , BLOCK, Timothy M. , GUO, Ju-Tao , XU, Xiaodong , LU, Huagang , CAI, Dawei
IPC分类号： A61K31/4745
CPC分类号： C07D471/04 , A61K31/4409 , A61K31/445 , A61K31/4465 , A61K31/505 , C07C311/21 , C07C317/32 , C07D209/08 , C07D211/26 , C07D211/34 , C07D211/60 , C07D213/40 , C07D213/56 , C07D213/76 , C07D235/08 , C07D239/26 , C07D263/56 , C07D277/64 , C07D295/135 , C07D295/155 , C07D401/12
摘要： Pharmaceutical compositions of the invention comprise covalently closed circular DNA formation inhibitors having a disease-modifying action in the treatment of diseases associated with the formation of covalently closed circular DNA that include hepatitis B infection, and any disease involving formation of covalently closed circular DNA.
摘要翻译： 本发明的药物组合物包含共价闭合环状DNA形成抑制剂具有在具有共价闭合环状DNA的形成相关的疾病的治疗疾病缓解动作确实包括乙型肝炎病毒感染，和任何疾病涉及形成共价闭合环状DNA的。
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6.发明公开NOVEL ANTIVIRAL AGENTS AGAINST HBV INFECTION 审中-公开NEUARTIGE ANTIVIRALE WIRKSTOFFE GEGEN HBV-INFEKTION
公开(公告)号：EP2938338A2
公开(公告)日：2015-11-04
申请号：EP13868405.5
申请日：2013-12-27
发明人： BAUGH, Simon David Peter , YE, Hong , XU, Xiaodong , GUO, Ju-tao , XIAO, Tong , DU, Yanming , BLOCK, Timothy
IPC分类号： A61K31/165 , A61K31/18
CPC分类号： C07C311/16 , C07B2200/07 , C07C233/66 , C07C309/89 , C07C311/17 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/48 , C07C317/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D203/26 , C07D205/04 , C07D211/96 , C07D213/40 , C07D213/75 , C07D213/76 , C07D215/38 , C07D215/42 , C07D217/24 , C07D231/40 , C07D231/42 , C07D239/26 , C07D261/14 , C07D263/48 , C07D263/50 , C07D263/58 , C07D277/46 , C07D277/52 , C07D295/26 , C07D295/30 , C07D295/32 , C07D305/08 , C07D309/04 , C07D319/16 , C07D319/18
摘要： The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as nucleocapsid assembly inhibitors. In other embodiments, the compounds of the invention are useful as pregenomic RNA encapsidation inhibitors of Hepatitis B virus (HBV). In yet other embodiments, the compounds of the invention are useful for the treatment of viral infection, including HBV and related viral infections.
摘要翻译： 本发明提供新的式（I）化合物及其使用方法。 在某些实施方案中，本发明的化合物可用作核衣壳组装抑制剂。 在其它实施方案中，本发明的化合物可用作乙型肝炎病毒（HBV）的前基因组RNA包封抑制剂。 在其它实施方案中，本发明的化合物可用于治疗病毒感染，包括HBV和相关病毒感染。
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7.发明公开FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION 审中-公开官能化的苯甲酰胺衍生物作为针对HBV感染的抗病毒剂
公开(公告)号：EP2928459A2
公开(公告)日：2015-10-14
申请号：EP13859675.4
申请日：2013-12-05
发明人： XU, Xiaodong , BLOCK, Timothy, M. , GUO, Ju-Tao , DU, Yanming
IPC分类号： A61K31/165
CPC分类号： C07C233/66 , C07C233/75 , C07C235/64 , C07C2602/10 , C07D317/46 , C07D317/68 , C07D319/18 , C07D321/10 , C07D333/68 , C07D333/70 , C07D333/72 , C07D495/04
摘要： Pharmaceutical compositions of the invention comprise functionalized benzamide derivatives useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.
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公开(公告)号：EP3157944B1
公开(公告)日：2019-10-09
申请号：EP15733379.0
申请日：2015-06-19
发明人： GUO, Haitao , CAI, Dawei , CUCONATI, Andrea , JI, Changhua
IPC分类号： C07K14/005 , G01N33/576
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公开(公告)号：EP3521303A1
公开(公告)日：2019-08-07
申请号：EP19158753.4
申请日：2015-06-19
发明人： GUO, Haitao , CAI, Dawei , CUCONATI, Andrea , JI, Changhua
IPC分类号： C07K14/005 , G01N33/576
摘要： The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
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公开(公告)号：EP3481810A1
公开(公告)日：2019-05-15
申请号：EP17828262.0
申请日：2017-07-11
IPC分类号： C07D277/42 , C07D495/04
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