公开(公告)号：EP3096798B1

公开(公告)日：2020-11-25

申请号：EP15740774.3

申请日：2015-01-21

申请人： Dyax Corp.

发明人： CHYUNG, Yung ,  SEXTON, Daniel J. ,  TENHOOR, Christopher ,  KENNISTON, Jon A. ,  FAUCETTE, Ryan ,  IARROBINO, Ryan ,  BIEDENKAPP, Joseph ,  ADELMAN, Burt

IPC分类号： A61K49/00 ,  A61K39/395 ,  C07K16/00 ,  G01N33/53

公开(公告)号：EP3513197A1

公开(公告)日：2019-07-24

申请号：EP17777137.5

申请日：2017-09-15

申请人： Dyax Corp.

发明人： SEXTON, Daniel, J. ,  VISWANATHAN, Malini ,  FAUCETTE, Ryan ,  GAUR, Tripti

IPC分类号： G01N33/68

公开(公告)号：EP3240570A1

公开(公告)日：2017-11-08

申请号：EP15876336.7

申请日：2015-12-31

申请人： Dyax Corp.

发明人： COMEAU, Stephen, R. ,  NIXON, Andrew ,  KASTRAPELI, Niksa ,  KENNISTON, Jon, A. ,  CONLEY, Gregory, P. ,  MASON, Shauna ,  LINDBERG, Allison, P. ,  KOPACZ, Kristopher ,  ADELMAN, Burt

IPC分类号： A61K39/395 ,  A61P7/10 ,  C07K16/40 ,  C12N9/64

CPC分类号： C07K16/40 ,  A61K39/395 ,  A61P7/02 ,  C07K16/36 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/94 ,  C12N9/64

摘要： Described herein are bispecific antibodies that bind to plasma kallikrein (pKal) and Factor XII and methods of producing and using such bi-specific antibodies for treating diseases or disorders associated with the contact system, e.g., hereditary angioedema or thrombosis. One aspect of the present disclosure is a bispecific antibody, comprising: a first polypeptide that comprises a light chain of a first antibody, the light chain comprising a light chain variable region (VL) and a light chain constant region (CL) (e.g., a kappa light chain or a lambda light chain); and a second polypeptide that comprises a heavy chain of the first antibody, the heavy chain comprising a heavy chain variable region (VH) and a heavy chain constant region (CH).

公开(公告)号：EP3060582A4

公开(公告)日：2017-07-19

申请号：EP14856778

申请日：2014-10-17

申请人： DYAX CORP

发明人： SEXTON DANIEL J ,  FAUCETTE RYAN ,  KENNISTON JON A ,  CONLEY GREGORY P ,  NIXON ANDREW ,  TENHOOR CHRISTOPHER ,  ADELMAN BURT

IPC分类号： C12Q1/37 ,  C07K16/40 ,  C12Q1/56

CPC分类号： G01N33/6893 ,  A61K2039/505 ,  C07K16/36 ,  C07K16/40 ,  C07K2317/76 ,  C12Q1/37 ,  C12Q1/56 ,  C12Y304/21034 ,  C12Y304/21038 ,  G01N2333/4713 ,  G01N2333/96455 ,  G01N2333/96458 ,  G01N2500/02 ,  G01N2500/20 ,  G01N2800/224 ,  G01N2800/50 ,  G01N2800/52

摘要： Methods and assays for determining the activation level of the plasma kallikrein (pKal) system and the uses thereof for assessing the activity of pKal modulators on the pKal system.

摘要翻译： 用于确定血浆激肽释放酶（pKal）系统的活化水平的方法和测定法及其用于评估pKal系统上的pKal调节剂活性的用途。

公开(公告)号：EP3096798A1

公开(公告)日：2016-11-30

申请号：EP15740774.3

申请日：2015-01-21

申请人： Dyax Corp.

发明人： CHYUNG, Yung ,  SEXTON, Daniel J. ,  TENHOOR, Christopher ,  KENNISTON, Jon A. ,  FAUCETTE, Ryan ,  LARROBINO, Ryan ,  BIEDENKAPP, Joseph ,  ADELMAN, Burt

IPC分类号： A61K49/00 ,  A61K39/395 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07K16/40 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Provided herein are plasma kallikrein binding proteins such as antibodies binding to active plasma kallikrein and methods of using such proteins in treating hereditary angioedema.

摘要翻译： 本文提供血浆激肽释放酶结合蛋白，例如结合活性血浆激肽释放酶的抗体以及使用这些蛋白质治疗遗传性血管性水肿的方法。

公开(公告)号：EP1854477B1

公开(公告)日：2016-08-03

申请号：EP07005182.6

申请日：2007-03-13

申请人： Dyax Corp.

发明人： Belichard, Pierre

IPC分类号： A61K38/55 ,  A61P27/02

CPC分类号： A61K38/57

摘要： The present invention relates to compositions and methods for treating ophthalmic disorders of humans or animals. The present compositions and methods are highly suitable for intraocular administration into the interior of an eye and provide therapeutic effects to the eye as they are effective in stabilizing, enhancing and/or improving a patient's vision. More specifically, the present invention relates to compositions and methods for treating ophthalmic diseases or disorders with exudative, hemorrhagic and/or inflammatory conditions. Even more specifically, the present invention relates to compositions and methods for treating retinal diseases or disorders, and more specifically ophthalmic diseases or disorders related to impaired retinal vessel permeability and/or integrity.

公开(公告)号：EP2948479A1

公开(公告)日：2015-12-02

申请号：EP14740444.6

申请日：2014-01-17

申请人： Dyax Corp.

发明人： SEXTON, Daniel, J. ,  FAUCETTE, Ryan ,  KENNISTON, Jon, A. ,  CONLEY, Greg ,  NIXON, Andrew ,  TENHOOR, Christopher ,  ADELMAN, Burt ,  CHYUNG, Yung

IPC分类号： C07K16/40

CPC分类号： G01N33/5735 ,  C07K7/06 ,  C07K16/36 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/76 ,  G01N2333/745 ,  G01N2800/065 ,  G01N2800/102 ,  G01N2800/52 ,  G01N2800/70

摘要： The present disclosure provides methods of evaluating a subject, e.g., a subject at risk for or suffering from a pKal-mediated or bradykinin-mediated disorder, based on values (e.g., percentages) of intact and/or cleaved kininogen in a sample of the subject. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (KMA), or other diseases mediated by pKal useful in the evaluation and treatment. Such methods can involve the use of a detection agent that preferentially binds cleaved kininogen or intact kininogen.

公开(公告)号：EP2284180B1

公开(公告)日：2015-09-09

申请号：EP10185426.3

申请日：2004-03-03

申请人： Dyax Corp. ,  Bracco Suisse SA

发明人： Sato, Aaron K. ,  Dransfield, Daniel T. ,  Ladner, Robert C. ,  Nanjappan, Palaniappa

IPC分类号： C07K7/08 ,  C07K14/475 ,  A61K38/10 ,  A61K38/18 ,  G01N33/68 ,  A61K47/48 ,  A61K49/00 ,  A61K51/08

CPC分类号： C07K7/08 ,  A61K47/543 ,  A61K47/60 ,  A61K47/665 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/08 ,  B82Y5/00 ,  C07K14/00 ,  C07K14/4753

摘要： A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.

公开(公告)号：EP2301587B1

公开(公告)日：2014-06-25

申请号：EP10185498.2

申请日：2003-03-03

申请人： Dyax Corp. ,  Bracco Suisse SA

发明人： Sato, Aaron K. ,  Sexton, Daniel J. ,  Dransfield, Daniel T. ,  Ladner, Robert C. ,  Arbogast, Christophe ,  Bussat, Philippe ,  Fan, Hong ,  Linder, Karen E. ,  Marinelli, Edmund R. ,  Nanjappan, Palaniappa ,  Nunn, Adrian D. ,  Pillai, Radhakrishna K. ,  Pochon, Sibylle ,  Ramalingam, Kondareddiar ,  Shrivastava, Ajay ,  Song, Bo ,  Swenson, Rolf E. ,  Von Wronski, Mathew A. ,  Yan, Feng

IPC分类号： A61K49/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/52 ,  C07K14/71

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K49/223 ,  A61K51/088 ,  C07K14/001 ,  C07K14/52 ,  C07K14/71 ,  C07K2319/00 ,  Y02A50/411 ,  Y02A50/58

摘要： The present invention provides binding polypeptides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity ( e . g ., having a K D

公开(公告)号：EP2741770A1

公开(公告)日：2014-06-18

申请号：EP12821512.6

申请日：2012-08-08

申请人： Athera Biotechnologies AB ,  Dyax Corp.

发明人： PETTERSSON, Knut ,  CAMBER, Ola ,  SEXTON, Dan ,  NIXON, Andrew, E.

IPC分类号： A61K39/00 ,  A61K39/395

CPC分类号： C07K16/44 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/92

摘要： The present disclosure relates to an antibody or antibody fragment capable of binding to phosphorylcholine and/or a phosphorylcholine conjugate, wherein the antibody or antibody fragment comprises a variable heavy chain (VH) domain and/or a variable light chain (VL) domain, and wherein (a) the VH domain comprises complementarity determining regions (CDRs) selected from the group consisting of: a CDR1 sequence having identity to the sequence of SEQ ID NO: 7; a CDR2 sequence having identity to the sequence of SEQID NO: 8; and a CDR3 sequence having identity to the sequence of SEQ ID NO: 9 or 10; and/or (b) the VL domain comprises CDRs selected from the group consisting of: a CDR4 sequence having identity to the sequence of SEQ ID NO: 11; a CDR5 sequence having identity to the sequence of SEQ ID NO: 12; a CDR6 sequence having identity to the sequence of SEQ ID NO: 13.