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51 条记录 (耗时 0.047 秒)

    ALPHA, BETA-UNSATURATED AMIDE COMPOUND
    4.
    发明公开
    ALPHA, BETA-UNSATURATED AMIDE COMPOUND 审中-公开

    公开(公告)号：EP3712129A1

    公开(公告)日：2020-09-23

    申请号：EP18819602.6

    申请日：2018-06-22

    申请人： Kyowa Kirin Co., Ltd.

    发明人： DANJO Tomohiro ,  YAMADA Hiroki ,  NAKAJIMA Takahiro

    IPC分类号： C07D213/75 ,  C07D215/20 ,  A61K31/335 ,  C07D215/26

    摘要： An object of the present invention is to provide an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like. The α,β-unsaturated amide compound represented by the following formula (I) or a pharmaceutically acceptable salt or the like thereof has anticancer activity and the like:

    [wherein, "A" represents optionally substituted heterocyclic diyl,
    R 1 represents hydrogen atom or optionally substituted lower alkyl,
    R 2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group,
    X represents -O-, -S-, -SO 2 -, -NR X1 - (wherein, R X1 represents hydrogen atom or lower alkyl), -CHR X2 - (wherein, R X2 represents hydrogen atom or hydroxy), -CH=CH-, -CO- or -NH-CO-, and
    n1 and n2 are the same or different, and each represents 0 or 1].

    HYPERPHOSPHATEMIA TREATMENT AGENT, AND PARTICLES
    5.
    发明公开
    HYPERPHOSPHATEMIA TREATMENT AGENT, AND PARTICLES 审中-公开

    公开(公告)号：EP3698798A1

    公开(公告)日：2020-08-26

    申请号：EP18868309.8

    申请日：2018-10-16

    申请人： FUJIFILM Corporation ,  Kyowa Kirin Co., Ltd.

    发明人： TOKUOKA Shinsuke ,  YOSHIDA Hayato ,  KONDO Yuichiro

    IPC分类号： A61K31/785 ,  A61K9/24 ,  A61K9/32 ,  A61K47/26 ,  A61K47/38 ,  A61P3/00 ,  A61P13/12

    摘要： The object of the present invention is to provide a therapeutic agent for hyperphosphatemia capable sufficiently decreasing a serum phosphorus concentration with a small dose, and particles therefor. The present invention provides a therapeutic agent for hyperphosphatemia, which comprises, as an active ingredient, a particle containing a crosslinked polymer having a substituent containing a NR A1 R A2 structure or a salt thereof, wherein the particle has an average particle diameter of 20 to 150 µm and a swelling rate of 9 to 16 mL/g (wherein R A1 and R A2 each independently represent a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aminoalkyl group having 1 to 20 carbon atoms or a salt thereof, or the like).