COMPOSITIONS AND METHODS TO PROMOTE BONE FORMATION
    5.
    发明公开
    COMPOSITIONS AND METHODS TO PROMOTE BONE FORMATION 审中-公开
    ZUSAMMENSETZUNGEN UND VERFAHREN ZURFÖRDERUNGDER KNOCHENBILDUNG

    公开(公告)号:EP3148517A4

    公开(公告)日:2017-05-17

    申请号:EP15799544

    申请日:2015-05-28

    摘要: This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSC) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteoradionecrosis.

    摘要翻译: 本公开涉及用于促进骨形成或减少骨质破坏的方法。 本公开还涉及用于促进骨髓间充质干细胞(MSC)募集到局部损伤部位或外科手术干预以促进愈合的方法。 另外,本公开涉及用于减少或预防矿物质形成或骨生长或减少骨质量的方法。 本文公开的方法可用于治疗诸如放射性骨坏死的病症。

    CROOS-LINKED PEPTIDES AND PROTEINS, METHODS OF MAKING SAME, AND USES THEREOF
    10.
    发明公开
    CROOS-LINKED PEPTIDES AND PROTEINS, METHODS OF MAKING SAME, AND USES THEREOF 有权
    VERNETZTE PEPTIDE UND PROTEINE,VERFAHREN ZU IHRER HERSTELLUNG UND VERWENDUNGEN DAVON

    公开(公告)号:EP2651964A4

    公开(公告)日:2014-10-15

    申请号:EP11848378

    申请日:2011-12-15

    摘要: Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.

    摘要翻译: 交联蛋白质和肽,以及制备和使用这种交联蛋白质和肽的方法。 交联的蛋白质和肽具有刚性的距离匹配双亚甲基芳基交联部分。 包含交联蛋白质和肽的组合物可用作药物递送制剂。 与亲本蛋白质或肽相比,交联的蛋白质和肽可以具有改善的性质,例如细胞渗透性。