利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

86 条记录 (耗时 0.021 秒)

    DIGITAL MICROFLUIDIC DEVICES WITH INTEGRATED ELECTROCHEMICAL SENSORS
    2.
    发明公开
    DIGITAL MICROFLUIDIC DEVICES WITH INTEGRATED ELECTROCHEMICAL SENSORS 审中-公开

    公开(公告)号：EP3210010A4

    公开(公告)日：2018-03-28

    申请号：EP15852188

    申请日：2015-10-21

    申请人： GOVERNING COUNCIL UNIV TORONTO

    发明人： WHEELER AARON R ,  YU YUE ,  SHAMSI MOHTASHIM

    IPC分类号： G01N27/403 ,  B01L3/00

    CPC分类号： G01N27/44791 ,  B01L3/502792 ,  B01L2300/0645 ,  B01L2400/0427 ,  G01N27/403 ,  G01N27/44721

    摘要： Devices and systems are provided in which one or more electrochemical sensors are integrated within a digital microfluidic device. According to one example embodiment, a two-electrode electrochemical sensor is integrated into a top or bottom plate of a digital microfluidic device, where the counter electrode is provided within a defined spatial region, and where the working electrode is formed such that it is spatially distributed within the spatial region associated with the counter electrode. The working electrode may be provided as one or more elongate segments that are spatially distributed within, and/or surround a perimeter of, the counter electrode. The area of the working electrode may be selected to be smaller than that of the counter electrode in order to improve the performance of the electrochemical sensor.

    SYSTEMS AND METHODS FOR MULTIPLEXED ELECTROCHEMICAL DETECTION
    5.
    发明授权
    SYSTEMS AND METHODS FOR MULTIPLEXED ELECTROCHEMICAL DETECTION 有权
    SYSTEME UND VERFAHRENFÜRGEMULTIPLEXTEN ELEKTROCHEMISCHEN NACHWEIS

    公开(公告)号：EP2859340B1

    公开(公告)日：2017-05-03

    申请号：EP13794214

    申请日：2013-03-15

    申请人： GOVERNING COUNCIL UNIV TORONTO

    发明人： KELLEY SHANA OLWYN ,  LAM BRIAN ,  SARGENT EDWARD HARTLEY

    IPC分类号： G01N27/26

    CPC分类号： G01N27/416 ,  C12Q1/001 ,  C12Q1/6825 ,  C12Q1/6876 ,  G01N27/27 ,  G01N27/3275 ,  G01N27/403 ,  G01N33/5438 ,  C12Q2563/137 ,  C12Q2565/607

    摘要： Contemplated methods and devices comprise performing electrochemical sample analysis in a multiplexed electrochemical detector having reduced electrical cross-talk. The electrochemical detector includes electrodes that share a common lead from a plurality of leads. The sample, which may be a liquid sample, is introduced into one or more sample wells and a signal is applied to at least one of the electrodes. A response signal is measured while simultaneously applying a substantially fixed potential to each of a remainder of the plurality of leads.

    摘要翻译： 考虑的方法和装置包括在具有减少的电串扰的多路复用电化学检测器中执行电化学样本分析。 电化学检测器包括共享来自多个引线的共同引线的电极。 可以是液体样品的样品被引入到一个或多个样品孔中，并且信号被施加到至少一个电极。 测量响应信号，同时向多个引线的其余部分中的每一个施加基本上固定的电位。

    SCAFFOLDED PEPTIDIC LIBRARIES AND METHODS OF MAKING AND SCREENING THE SAME
    7.
    发明公开
    SCAFFOLDED PEPTIDIC LIBRARIES AND METHODS OF MAKING AND SCREENING THE SAME 审中-公开
    多伦多大卫·德维恩·多德维奇

    公开(公告)号：EP2971290A4

    公开(公告)日：2017-03-01

    申请号：EP14765544

    申请日：2014-03-14

    申请人： GOVERNING COUNCIL UNIV TORONTO

    发明人： UPPALAPATI MARUTI ,  SIDHU SACHDEV S ,  KERMAN AARON

    IPC分类号： C40B40/10 ,  C40B30/04 ,  C40B40/08

    CPC分类号： C12N15/1044 ,  C40B40/10

    摘要： Scaffolded peptidic libraries and methods of screening the same for specific binding to a target protein are provided. Each library includes distinct peptidic compounds that include a scaffold domain and a distinct variable domain. A variety of libraries are provided where each library is based on an underlying peptidic scaffold having a structural motif. In some embodiments, the peptidic scaffold is a small protein having a protein-protein interaction surface. Libraries of polynucleotides that encode a variety of peptidic compounds are provided. These libraries find use in a variety of applications in which specific binding to target molecules, e.g., target proteins is desired. Also provided are methods of making the libraries and methods of screening the libraries for binding to a target.

    摘要翻译： 提供了脚手架肽图谱库和筛选相同的特异性结合靶蛋白的方法。 每个文库包括不同的肽化合物，其包括支架结构域和不同可变结构域。 提供了各种文库，其中每个文库基于具有结构基序的下面的肽支架。 在一些实施方案中，肽支架是具有蛋白质 - 蛋白质相互作用表面的小蛋白质。 提供了编码多种肽化合物的多核苷酸的文库。 这些文库可用于其中需要特异性结合靶分子（例如靶蛋白）的多种应用。 还提供了制作图书馆和筛选文库以绑定到目标的方法的方法。