公开(公告)号：EP0864570A1

公开(公告)日：1998-09-16

申请号：EP98104063.7

申请日：1998-03-06

申请人： PLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo

发明人： Tomic, Mirjana M.Sc. ,  Kovacevic, Mice D.Sc.

IPC分类号： C07D405/04

CPC分类号： C07D405/04

摘要： The present invention relates to new epoxy-azetidinones of the general formula I, which are prepared by epoxidizing azetidinones of the general formula II.

These compounds are useful intermediates for the prepararion of new potential inhibitors of β-lactamases.

摘要翻译： 本发明涉及通式I的新的环氧 - 氮杂环丁酮，其通过环氧化通式II的氮杂环丁酮制备。 这些化合物是制备β-内酰胺酶新的潜在抑制剂的有用中间体。

公开(公告)号：EP0857172A1

公开(公告)日：1998-08-12

申请号：EP96925156.0

申请日：1996-05-20

申请人： Vitik, Andrej Zinovyevich

发明人： VITIK, Andrej Zinovyevich ,  GAZALIEV, Arstan Maulenovich ,  GULYAEV, Alexander Evgenyevich

IPC分类号： A61K31 ,  C07F9

CPC分类号： C07F9/6561

摘要： Synthesized recently phosphorus containing cethysine derivatives in general formula (I) have been stated, where n=0, 1; at n=0 X=S; R=CH3; C2H5; C3H7; 1=C3H7; C4H9 at n=1 X=0, R=CH3, R1=1-C3H7; C6H5; n-CH3O-. It has been shown that some of the synthesized compounds display high hepatoprotective and antienzyme activity.

公开(公告)号：EP0614915B1

公开(公告)日：1998-06-24

申请号：EP94103808.5

申请日：1994-03-11

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Shimizu, Toshihide ,  Watanabe, Mikio

IPC分类号： C08F2/00 ,  B01J19/00

CPC分类号： B01J19/002 ,  B01J2219/00252 ,  C08F2/004

公开(公告)号：EP0843712A1

公开(公告)日：1998-05-27

申请号：EP96928328.0

申请日：1996-07-25

申请人： Kief, Horst, Dr. med.

发明人： Kief, Horst, Dr. med.

IPC分类号： B01J31 ,  C10G27 ,  C10L1 ,  C10L10

CPC分类号： C10L1/1857 ,  C10G27/14 ,  C10L1/10 ,  C10L1/1208 ,  C10L1/1233 ,  C10L1/1275 ,  C10L1/1283 ,  C10L1/1608 ,  C10L1/18 ,  C10L1/1805 ,  C10L10/02

摘要： The proposed method of producing a homogeneous catalyst for fuels involves adding acetone or homologues of acetone to the fuel and enriching the fuel with carbonyl compounds, in particular glyoxal or polyglyoxal, by oxidation with O3 or O2/O3 mixtures. Enrichment takes place preferably in the presence of heterogeneous catalysts with oxidising properties. The heterogeneous catalysts which can be used are the metals iron, manganese, copper, cerium, molybdenum, tungsten, vanadium, bismuth, titanium, rhodium, platinum and palladium, or their oxides, sulphides, phosphates or mixtures. The application also concerns a fuel containing a homogeneous catalyst produced by this method.

公开(公告)号：EP0749943A3

公开(公告)日：1998-04-29

申请号：EP96109703.7

申请日：1996-06-17

申请人： Von Nordenskjöld, Reinhart, Dr.-Ing.

发明人： Von Nordenskjöld, Reinhart, Dr.-Ing.

IPC分类号： C02F3/30 ,  C02F3/12

CPC分类号： C02F3/308 ,  Y02W10/33 ,  Y10S210/903 ,  Y10S210/906

摘要： Gegenstand der Erfindung ist ein Verfahren und eine Anlage zum Reinigen von Abwasser in mehreren aufeinanderfolgenden Phasen, wobei in der ersten Phase (A) das Abwasser belüftet und in einer zweiten Phase (B), die auch eine Schlammrückführung aufweist, zwischengeklärt wird und wobei dann gegebenenfalls in einer dritten Phase (C) eine Nachbelüftung und in einer vierten Phase (D) eine Nachsedimentation erfolgt, wobei man die Reaktionsprozesse in einer vorgeschalteten anaeroben Phase beeinflußt, indem man die Verweilzeit durch Volumenanpassung verändert.

公开(公告)号：EP0829695A1

公开(公告)日：1998-03-18

申请号：EP96927961.1

申请日：1996-08-06

申请人： Gosudarstvenny Nauchny Tsentr Fiziko-Energetichesky Institut

发明人： GROMOV, Boris Fedorovich

IPC分类号： F28G1/16 ,  F28G3/16 ,  F28G9/00

CPC分类号： B08B9/027 ,  B08B2230/01 ,  F28G13/00

摘要： The method is to developed a two-phase flow in the circulation circuit. This method is defined by the fact, that a two-phase flow is developed by means of hydrogen introduction into the coolant. Hydrogen can be introduced in mixture with an inert gas or water steams.

摘要翻译： 该方法开发了在循环回路的两相流动。 此方法由以下事实所定义，做了一个二相流被氢引入的冷却剂的装置显影。 氢可以与惰性气体混合物在等于或水蒸引入。

公开(公告)号：EP0829556A1

公开(公告)日：1998-03-18

申请号：EP96927962.9

申请日：1996-08-06

申请人： Gosudarstvenny Nauchny Tsentr Fiziko-Energetichesky Institut

发明人： GROMOV, Boris Fedorovich

IPC分类号： C23F11/00

CPC分类号： F28F19/02 ,  C23C22/68 ,  C23F11/00 ,  F01D25/007

摘要： The method is to develop an anticorrosive cover out of oxides of structural steel components on a circuit internal surface. The method is defined by the fact, that in the course of the circuit operation, the oxygen concentration, which is dissolved in the coolant, is maintained not lower than the value, which has bean determined from the expression IgC=-0.33-2790/T+IgC s +IgJC Pb , where

C is the concentration of oxygen, dissolved in the coolant, mass %;
T is the coolant maximum temperature In the circuit, °K;
C s is the saturated concentration of oxygen dissolved in the coolant at the temperature T, mass %;
J is the thermodynamic activity coefficient of lead in the coolant, inverse mass %;
C Pb is the lead concentration in the coolant, mass %

摘要翻译： 所述的方法是在防腐盖开发出在电路内表面结构钢元件的氧化物。 该方法由以下事实所定义，“那个”在电路运行中，氧浓度，在所有这是在冷却剂溶解的过程中，保持为不大于该值，其中有豆确定性从表达式$其中C是开采的下\; 氧的浓度，在冷却剂中溶解，质量％;\; T是在电路中，°K的最高冷却剂温度;\; Cs为在氧气在温度T，质量％冷却剂溶解的饱和浓度;\; J是在冷却剂，逆质量％铅的热力学活性系数;\; CPB是在冷却剂中的铅浓度，质量％$

公开(公告)号：EP0705606B1

公开(公告)日：1998-03-18

申请号：EP95114673.7

申请日：1995-09-18

申请人： PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo

发明人： Kovacevic, Mice, D. Sc. ,  Grdisa, Mira, D. Sc. ,  Pavelic, Kresimir, D. Sc. ,  Horvatic, Marjeta, M. Sc. ,  Mandic, Zora M. Sc. ,  Tomic, Mirjana M. Sc. ,  Herak, Jure J., D. Sc. ,  Lukic, Irena, M. Sc.

IPC分类号： A61K31/54

CPC分类号： A61K31/549

公开(公告)号：EP0816353A2

公开(公告)日：1998-01-07

申请号：EP97110824.6

申请日：1997-07-01

申请人： PLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo

发明人： Trkovnik, Mladen ,  Ivezic, Zrinka ,  Polak, Ljerka

IPC分类号： C07D311/16

CPC分类号： C07D311/14 ,  C07D311/16 ,  C07D311/18

摘要： The present invention relates to new coumarin derivatives represented by the general formula I
wherein

R 1 = NH 2 or -NHCH=C(CO 2 C 2 H 5 ) 2 , R 2 = R 3 = R 4 = H, R 5 = F,
R 1 = R 3 = NHCH=C(CO 2 C 2 H 5 ) 2 , R 2 = R 4 = R 5 = H,
R 1 = H or OH, R 3 = NHCH=C(CO 2 C 2 H 5 ) 2 , R 2 = R 4 = R 5 = H,
R 1 = OH, R 2 = R 3 = R 4 = H, R 5 = -NHCH=C(CO 2 C 2 H 5 ) 2 ,
R 1 = R 3 = R 5 = H, R 2 = CH 3 or CF 3 , R 4 = -NHCH=C(CO 2 C 2 H 5 ) 2 ,
processes for the preparation thereof and their use as intermediates for the synthesis of new coumarin derivatives with potential biological action.

摘要翻译： 本发明涉及由通式I 表示的新香豆素衍生物，其中R 1 = NH 2或-NHCH = C（CO 2 C 2 H 5）2，R 2 = R 3 = R 4 = H R 5 = F，R 1 = R 3 = NHCH = C（CO 2 C 2 H 5）2，R 2 = R 4 = R 5 = H，R 1 = H或 OH，R 3 = NHCH = C（CO 2 C 2 H 5）2，R 2 = R 4 = R 5 = H，R 1 = OH，R 2 = R 3 = R 4 = H，R 5 = -NHCH = C（CO 2 C 2 H 5）2，R 1 = R 3 = R 5 = H，R 2 = CH 3或CF 3，R 4， = -NHCH = C（CO 2 C 2 H 5）2，其制备方法及其作为合成具有潜在生物作用的新香豆素衍生物的中间体的用途。

公开(公告)号：EP0704527A3

公开(公告)日：1997-08-27

申请号：EP95112210.0

申请日：1995-08-03

申请人： PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo

发明人： Mestric, Silvija ,  Punt, Peter J. ,  Valinger, Radovan ,  van den Hondel, Cees A.M.J.J.

IPC分类号： C12N15/17 ,  C12N1/15 ,  C12N15/62 ,  C07K14/62

CPC分类号： C07K14/62 ,  A61K38/00 ,  C07K2319/00 ,  C12N15/80

摘要： The present invention relates to DNA sequences encoding insulin precursors of formula B-Pg-A, wherein B and A represent B- and A-chains, respectively, and Pg represents modified C-peptide or any number of amino acids comprising at least one glycosylation consensus site. The invention also relates to a process for the preparation of insulin by culturing suitable cells, preferably fungal cells, transformed with a vector comprising DNA sequence encoding insulin precursor of given formula. The invention further relates to DNA sequences encoding pharmaceutical peptides and proteins in which N-glycosylation consensus site is introduced in a non-essential site in any spacer region for higher expression and secretion of proteins.