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    CELL-TARGETED MAGNETIC NANO-MATERIAL AND BIOMEDICAL USES THEREOF
    4.
    发明公开
    CELL-TARGETED MAGNETIC NANO-MATERIAL AND BIOMEDICAL USES THEREOF 审中-公开
    生物医药生物医学工程师大卫·维尔森

    公开(公告)号：EP2805733A1

    公开(公告)日：2014-11-26

    申请号：EP13739005.0

    申请日：2013-01-21

    申请人： Institute of Geology and Geophysics, Chinese Academy of Sciences

    发明人： PAN, Yongxin ,  CAO, Changqian ,  TIAN, Lanxiang ,  CAI, Yao ,  ZHU, Rixiang

    IPC分类号： A61K49/06 ,  C12N15/12 ,  C12N15/17 ,  C07K14/47

    CPC分类号： A61K49/1824 ,  A61K47/6923 ,  A61K49/1866 ,  C07K14/47

    摘要： Disclosed are a cell-targeted nano-material and biomedical uses thereof. The magnetic nano-material can bind with specificity to iron protein receptors having high expression on the surface of tissue cells, and can enter the cells. The present material can bind with specificity to a broad spectrum of tissue cells having a high expression of iron protein receptors, and can enable highly efficient cell targeting in animal models. The material can be used as a magnetic resonance imaging contrast and a fluorescent molecular probe for disease diagnosis, as well as a vector of medicine for disease treatment.

    摘要翻译： 公开了细胞靶向纳米材料及其生物医学用途。 磁性纳米材料可以特异性结合组织细胞表面高表达的铁蛋白受体，并能进入细胞。 本发明的材料可以特异性结合具有铁蛋白受体表达的高表达的组织细胞，并且可以在动物模型中实现高效的细胞靶向。 该材料可用作磁共振成像对比度和用于疾病诊断的荧光分子探针，以及用于疾病治疗的药物载体。

    INSULIN ANALOGUES WITH CHLORINATED AMINO ACIDS
    5.
    发明公开
    INSULIN ANALOGUES WITH CHLORINATED AMINO ACIDS 审中-公开
    胰岛素类似物氯化氨基酸

    公开(公告)号：EP2509995A2

    公开(公告)日：2012-10-17

    申请号：EP10836802.8

    申请日：2010-12-13

    申请人： Case Western Reserve University

    发明人： WEISS, Michael

    IPC分类号： C07K14/62 ,  C12N15/17 ,  A61K38/28 ,  A61P3/10

    CPC分类号： C07K14/62 ,  A61K38/00

    摘要： An insulin analogue comprises a B-chain polypeptide incorporating a chlorinated phenylalanine. The chlorinated phenylalanine may be located at position B24. The chlorinated phenylalanine may be para-monochloro-phenylalanine. The analogue may be of a mammalian insulin, such as human insulin. A nucleic acid encodes such an insulin analogue. The chlorinated insulin analogues retain significant activity. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. Chlorine substitution-based stabilization of insulin may reduce fibrillation and thereby enhance the treatment of diabetes mellitus in regions of the developing world lacking refrigeration.

    Plastid transformation vectors for expressing proinsulin fused to the cholera toxin B-subunit in plants
    7.
    发明公开
    Plastid transformation vectors for expressing proinsulin fused to the cholera toxin B-subunit in plants 有权
    Plastidtransformationsvektoren zur表达von胰岛素原，das an die霍乱毒素B-Untereinheit fusioniert ist，in Pflanzen

    公开(公告)号：EP2080803A1

    公开(公告)日：2009-07-22

    申请号：EP08020922.4

    申请日：2001-02-28

    申请人： Auburn University ,  UNIVERSITY OF CENTRAL FLORIDA

    发明人： Daniell, Henry

    IPC分类号： C12N15/14 ,  C12N15/16 ,  C12N15/17 ,  C12N15/20 ,  C12N15/21 ,  C12N15/31 ,  C12N15/32 ,  C12N15/62 ,  C12N15/82 ,  C12P21/02 ,  A01H5/00

    CPC分类号： C12N15/62 ,  C07K14/28 ,  C07K14/62 ,  C07K14/765 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/50 ,  C07K2319/55 ,  C07K2319/75 ,  C12N15/8214 ,  C12N15/8257

    摘要： A plastid transformation and expression vector which comprises an expression cassette comprising as operably linked components, in the 5' to the 3' direction of translation, a promoter operative in said plastid, a selectable marker sequence, a heterologous DNA sequence coding for cholera toxin B-subunit fused to proinsulin, a transcription termination region functional in said plastid, and flanking, each side of the expression cassette, flanking DNA sequences which are homologous to a DNA sequence inclusive of a spacer sequence of the target plastid genome, and, whereby stable integration of the heterologous coding sequence into the plastid genome of the target plant is facilitated throughout homologous recombination of the flanking sequence with the homologous sequences in the target plastid genome.

    摘要翻译： 一种质体转化和表达载体，其包含包含翻译的5'至3'方向的可操作地连接的组分的表达盒，在所述质体中可操作的启动子，可选择标记序列，编码霍乱毒素B的异源DNA序列 亚单位与胰岛素原融合，在所述质体中有功能的转录终止区，并且表达盒的每一侧的侧翼，与包含靶质粒基因组的间隔序列的DNA序列同源的侧翼DNA序列，并且由此稳定 整个异源编码序列整合到靶植物的质体基因组中，可以在侧翼序列与靶质粒基因组中的同源序列的同源重组中实现。

    PROCESSES FOR MAKING ACYLATED INSULIN
    8.
    发明公开
    PROCESSES FOR MAKING ACYLATED INSULIN 审中-公开
    用于生产胰岛素酰化

    公开(公告)号：EP1687428A1

    公开(公告)日：2006-08-09

    申请号：EP04797444.9

    申请日：2004-11-11

    申请人： NOVO NORDISK A/S

    发明人： KJELDSEN, Thomas, Börglum ,  MARKUSSEN, Jan

    IPC分类号： C12N15/17 ,  C07K14/62 ,  C12P21/06

    CPC分类号： C12P21/06 ,  C07K14/62

    摘要： A method is provided which allows high yields of acylated insulin. The method comprises expressing a singe-chain insulin precursor, preferably in yeast, cleaving the single-chain insulin precursor with a suitable protease which will open the peptide bond between the C-terminal amino group in the B-chain and a connecting peptide connecting the B chain with the A-chain, acylating the two-chain insulin intermediate in the e-amino group in LysB29 and subjecting the acylated two-chain insulin intermediate to a proteolytic enzyme which will cleave of the N-terminal extension on the B- and A-chains on the precursor molecule.